Search Results - "Binda, Francesca"

Increased responsiveness at the cerebellar input stage in the PRRT2 knockout model of paroxysmal kinesigenic dyskinesia by Binda, Francesca, Valente, Pierluigi, Marte, Antonella, Baldelli, Pietro, Benfenati, Fabio

“…PRoline-Rich Transmembrane protein-2 (PRRT2) is a recently described neuron-specific type-2 integral membrane protein with a large cytosolic N-terminal domain…”
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The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations by Michetti, Caterina, Castroflorio, Enrico, Marchionni, Ivan, Forte, Nicola, Sterlini, Bruno, Binda, Francesca, Fruscione, Floriana, Baldelli, Pietro, Valtorta, Flavia, Zara, Federico, Corradi, Anna, Benfenati, Fabio

“…Abstract Heterozygous and rare homozygous mutations in PRoline-Rich Transmembrane protein 2 (PRRT2) underlie a group of paroxysmal disorders including…”
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Cerebellar Development and Circuit Maturation: A Common Framework for Spinocerebellar Ataxias by Binda, Francesca, Pernaci, Carla, Saxena, Smita

“…Spinocerebellar ataxias (SCAs) affect the cerebellum and its afferent and efferent systems that degenerate during disease progression. In the cerebellum,…”
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Differential Coding Strategies in Glutamatergic and GABAergic Neurons in the Medial Cerebellar Nucleus by Özcan, Orçun Orkan, Wang, Xiaolu, Binda, Francesca, Dorgans, Kevin, De Zeeuw, Chris I, Gao, Zhenyu, Aertsen, Ad, Kumar, Arvind, Isope, Philippe

“…The cerebellum drives motor coordination and sequencing of actions at the millisecond timescale through adaptive control of cerebellar nuclear output…”
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The Secreted Protein C1QL1 and Its Receptor BAI3 Control the Synaptic Connectivity of Excitatory Inputs Converging on Cerebellar Purkinje Cells by Sigoillot, Séverine M., Iyer, Keerthana, Binda, Francesca, González-Calvo, Inés, Talleur, Maëva, Vodjdani, Guilan, Isope, Philippe, Selimi, Fekrije

“…Precise patterns of connectivity are established by different types of afferents on a given target neuron, leading to well-defined and non-overlapping synaptic…”
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Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex by Valera, Antoine M, Binda, Francesca, Pawlowski, Sophie A, Dupont, Jean-Luc, Casella, Jean-François, Rothstein, Jeffrey D, Poulain, Bernard, Isope, Philippe

“…Motor coordination is supported by an array of highly organized heterogeneous modules in the cerebellum. How incoming sensorimotor information is channeled and…”
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Socio-economic conditions affect health-related quality of life, during recovery from acute SARS-CoV-2 infection by Benatti, Simone Vasilij, Venturelli, Serena, Buzzetti, Roberto, Binda, Francesca, Belotti, Luca, Soavi, Laura, Biffi, Ave Maria, Spada, Maria Simonetta, Casati, Monica, Rizzi, Marco, Alessio, Maria Grazia, Ambaglio, Chiara, Barbui, Tiziano, Bonaffini, Pietro Andrea, Bondi, Emi, Camera, Giorgia, Carioli, Greta, Carobbio, Alessandra, Cesa, Simonetta, Conti, Caterina, Cosentini, Roberto, Crotti, Giacomo, Falanga, Anna, Gerevini, Simonetta, Ghirardi, Arianna, Giammarresi, Andrea, Greco, Giuseppe, Imeri, Gianluca, Marchetti, Marina, Marinaro, Claudia, Ouabou, Aicha, Pellegrini, Ramona, Previtali, Giulia, Quinzan, Giampaolo, Rossini, Alessandro, Seghezzi, Michela, Sessa, Maria, Severgnini, Roberta, Suardi, Claudia, Zanoletti, Adriana, Zucchi, Alberto, Zuglian, Gianluca

“…Recovery from acute COVID-19 may be slow and incomplete: cases of Post-Acute Sequelae of COVID (PASC) are counted in millions, worldwide. We aimed to explore…”
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Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors by Wellbourne-Wood, Joel, Briquet, Marc, Alessandri, Maxime, Binda, Francesca, Touya, Maylis, Chatton, Jean-Yves

“…The status of lactate has evolved from being considered a waste product of cellular metabolism to a useful metabolic substrate and, more recently, to a…”
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HIV-1 A1 Subtype Epidemic in Italy Originated from Africa and Eastern Europe and Shows a High Frequency of Transmission Chains Involving Intravenous Drug Users by Lai, Alessia, Bozzi, Giorgio, Franzetti, Marco, Binda, Francesca, Simonetti, Francesco R, De Luca, Andrea, Micheli, Valeria, Meraviglia, Paola, Bagnarelli, Patrizia, Di Biagio, Antonio, Monno, Laura, Saladini, Francesco, Zazzi, Maurizio, Zehender, Gianguglielmo, Ciccozzi, Massimo, Balotta, Claudia

“…Subtype A accounts for only 12% of HIV-1 infections worldwide but predominates in Russia and Former Soviet Union countries of Eastern Europe. After an early…”
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Amphetamine Induces Dopamine Efflux through a Dopamine Transporter Channel by Kahlig, Kristopher M., Binda, Francesca, Khoshbouei, Habibeh, Blakely, Randy D., McMahon, Douglas G., Javitch, Jonathan A., Galli, Aurelio, Amara, Susan G.

“…Drugs of abuse, including cocaine, amphetamine (AMPH), and heroin, elevate extracellular dopamine (DA) levels in the brain, thereby altering the…”
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Paroxysmal Nocturnal Hemoglobinuria (Pnh): Brain Mri Ischemic Lesions In Neurologically Asymtomatic Patients by Barcellini, Wilma, Scola, Elisa, Lanfranconi, Silvia, Grottaroli, Marika, Binda, Francesca, Fattizzo, Bruno, Zaninoni, Anna, Valcamonica, Gloria, Cinnante, Claudia Maria, Boschetti, Carla, Buoli, Massimiliano, Altamura, Carlo Alfredo, Bresolin, Nereo, Triulzi, Fabio, Zanella, Alberto, Cortelezzi, Agostino

“…This study investigated for the first time brain ischemic involvement in 19 consecutive neurologically asymptomatic PNH patients by non-enhanced cerebral MRI,…”
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Imatinib and ruxolitinib association: first experience in two patients by Iurlo, Alessandra, Gianelli, Umberto, Rapezzi, Davide, Cattaneo, Daniele, Fermo, Elisa, Binda, Francesca, Santambrogio, Elisa, Bucelli, Cristina, Cortelezzi, Agostino

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Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux by Binda, Francesca, Dipace, Concetta, Bowton, Erica, Robertson, Sabrina D, Lute, Brandon J, Fog, Jacob U, Zhang, Minjia, Sen, Namita, Colbran, Roger J, Gnegy, Margaret E, Gether, Ulrik, Javitch, Jonathan A, Erreger, Kevin, Galli, Aurelio

“…The soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein syntaxin 1A (SYN1A) interacts with and regulates the function of…”
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A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation by Guptaroy, Bipasha, Zhang, Minjia, Bowton, Erica, Binda, Francesca, Shi, Lei, Weinstein, Harel, Galli, Aurelio, Javitch, Jonathan A, Neubig, Richard R, Gnegy, Margaret E

“…The human dopamine transporter (hDAT) regulates synaptic dopamine (DA) levels and is the site of action of abused and therapeutic drugs. Here we study the…”
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Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes by Dipace, Concetta, Sung, Uhna, Binda, Francesca, Blakely, Randy D, Galli, Aurelio

“…Norepinephrine (NE) transporters (NETs) are high-affinity transport proteins that mediate the synaptic clearance of NE after vesicular release. NETs represent…”
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Low-dose alemtuzumab-associated immune thrombocytopenia in chronic lymphocytic leukemia by Reda, Gianluigi, Maura, Francesco, Gritti, Giuseppe, Gregorini, Anna, Binda, Francesca, Guidotti, Francesca, Piciocchi, Alfonso, Visco, Carlo, Rodeghiero, Francesco, Cortelezzi, Agostino

“…Chronic lymphocytic leukemia (CLL) is frequently complicated during its course by autoimmune disorders (from 2 to 12% of cases), such as autoimmune hemolytic…”
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Excitation and Inhibition Delays within a Feedforward Inhibitory Pathway Modulate Cerebellar Purkinje Cell Output in Mice by Binda, Francesca, Spaeth, Ludovic, Kumar, Arvind, Isope, Philippe

“…The cerebellar cortex computes sensorimotor information from many brain areas through a feedforward inhibitory (FFI) microcircuit between the input stage, the…”
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The relation between charge movement and transport-associated currents in the rat GABA cotransporter rGAT1 by Fesce, Riccardo, Giovannardi, Stefano, Binda, Francesca, Bossi, Elena, Peres, Antonio

“…Most cotransporters characteristically display two main kinds of electrical activity: in the absence of organic substrate, transient presteady-state currents (…”
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Mutation K448E in the external loop 5 of rat GABA transporter rGAT1 induces pH sensitivity and alters substrate interactions by Forlani, Greta, Bossi, Elena, Ghirardelli, Roberta, Giovannardi, Stefano, Binda, Francesca, Bonadiman, Lorena, Ielmini, Lorena, Peres, Antonio

“…The effect of the mutation K448E in the rat GABA transporter rGAT1 was studied using heterologous expression in Xenopus oocytes and voltage clamp. At neutral…”
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Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab by Rambaldi, Alessandro, Gritti, Giuseppe, Micò, Maria Caterina, Frigeni, Marco, Borleri, Gianmaria, Salvi, Anna, Landi, Francesco, Pavoni, Chiara, Sonzogni, Aurelio, Gianatti, Andrea, Binda, Francesca, Fagiuoli, Stefano, Di Marco, Fabiano, Lorini, Luca, Remuzzi, Giuseppe, Whitaker, Steve, Demopulos, Gregory

“…•Narsoplimab down-modulates SARS-CoV-2-induced activation of the lectin pathway and endothelial cell damage.•Narsoplimab can reduce the thrombotic risk of…”
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