Search Results - "Bilsel, Osman"

Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri‐doped Upconversion Colloidal Nanoparticles at 800 nm by Shen, Jie, Chen, Guanying, Vu, Anne‐Marie, Fan, Wei, Bilsel, Osman S., Chang, Chun‐Chih, Han, Gang

“…Cascade‐sensitized 800 nm excited tri‐doped upconversion nanoparticles (UCNPs) are developed for the first time. This novel class of UCNPs employ Nd3+ as an…”
Get full text

Tailoring dye-sensitized upconversion nanoparticle excitation bands towards excitation wavelength selective imaging by Wu, Xiang, Lee, Hyungseok, Bilsel, Osman, Zhang, Yuanwei, Li, Zhanjun, Chen, Teresa, Liu, Yi, Duan, Chunying, Shen, Jie, Punjabi, Amol, Han, Gang

“…One of the key roadblocks in UCNP development is its extremely limited choices of excitation wavelengths. We report a generic design to program UCNPs to…”
Get more information

Transient Kinetic Analysis of SWR1C-Catalyzed H2A.Z Deposition Unravels the Impact of Nucleosome Dynamics and the Asymmetry of Histone Exchange by Singh, Raushan K., Fan, Jiayl, Gioacchini, Nathan, Watanabe, Shinya, Bilsel, Osman, Peterson, Craig L.

“…The SWR1C chromatin remodeling enzyme catalyzes ATP-dependent replacement of nucleosomal H2A with the H2A.Z variant, regulating key DNA-mediated processes such…”
Get full text

Frustration and folding of a TIM barrel protein by Halloran, Kevin T., Wang, Yanming, Arora, Karunesh, Chakravarthy, Srinivas, Irving, Thomas C., Bilsel, Osman, Brooks, Charles L., Matthews, C. Robert

“…Triosephosphate isomerase (TIM) barrel proteins have not only a conserved architecture that supports a myriad of enzymatic functions, but also a conserved…”
Get full text

Computer design of microfluidic mixers for protein/RNA folding studies by Inguva, Venkatesh, Kathuria, Sagar V, Bilsel, Osman, Perot, Blair James

“…Kinetic studies of biological macromolecules increasingly use microfluidic mixers to initiate and monitor reaction progress. A motivation for using…”
Get full text

Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes by Das, Sanchaita, Malaby, Andrew W., Nawrotek, Agata, Zhang, Wenhua, Zeghouf, Mahel, Maslen, Sarah, Skehel, Mark, Chakravarthy, Srinivas, Irving, Thomas C., Bilsel, Osman, Cherfils, Jacqueline, Lambright, David G.

“…Membrane dynamic processes require Arf GTPase activation by guanine nucleotide exchange factors (GEFs) with a Sec7 domain. Cytohesin family Arf GEFs function…”
Get full text

Methods for analysis of size-exclusion chromatography-small-angle X-ray scattering and reconstruction of protein scattering by Malaby, Andrew W., Chakravarthy, Srinivas, Irving, Thomas C., Kathuria, Sagar V., Bilsel, Osman, Lambright, David G.

“…Size‐exclusion chromatography in line with small‐angle X‐ray scattering (SEC–SAXS) has emerged as an important method for investigation of heterogeneous and…”
Get full text

Native State Conformational Heterogeneity of HP35 Revealed by Time-Resolved FRET by Serrano, Arnaldo L, Bilsel, Osman, Gai, Feng

“…The villin headpiece subdomain (HP35) has become one of the most widely used model systems in protein folding studies, due to its small size and ultrafast…”
Get full text

Creating round focused micro-jets from rectangular nozzles by Inguva, Venkatesh, Graceffa, Rita, Schulz, Joachim, Bilsel, Osman, Perot, Blair J.

“…A focused jet is an axisymmetric jet of liquid surrounded by an outer coaxial gas jet. The gas jet is typically used to compress the liquid jet in the radial…”
Get full text

Microsecond Barrier-Limited Chain Collapse Observed by Time-Resolved FRET and SAXS by Kathuria, Sagar V., Kayatekin, Can, Barrea, Raul, Kondrashkina, Elena, Graceffa, Rita, Guo, Liang, Nobrega, R. Paul, Chakravarthy, Srinivas, Matthews, C. Robert, Irving, Thomas C., Bilsel, Osman

“…It is generally held that random-coil polypeptide chains undergo a barrier-less continuous collapse when the solvent conditions are changed to favor the fully…”
Get full text

Sub-millisecond time-resolved SAXS using a continuous-flow mixer and X-ray microbeam by Graceffa, Rita, Nobrega, R. Paul, Barrea, Raul A., Kathuria, Sagar V., Chakravarthy, Srinivas, Bilsel, Osman, Irving, Thomas C.

“…Small‐angle X‐ray scattering (SAXS) is a well established technique to probe the nanoscale structure and interactions in soft matter. It allows one to study…”
Get full text

Microsecond acquisition of heterogeneous structure in the folding of a TIM barrel protein by Wu, Ying, Kondrashkina, Elena, Kayatekin, Can, Matthews, C. Robert, Bilsel, Osman

“…The earliest kinetic folding events for (βα)₈ barrels reflect the appearance of off-pathway intermediates. Continuous-flow microchannel mixing methods…”
Get full text

Non-Native Structure Appears in Microseconds during the Folding of E. coli RNase H by Rosen, Laura E., Kathuria, Sagar V., Matthews, C. Robert, Bilsel, Osman, Marqusee, Susan

“…The folding pathway of Escherichia coli RNase H is one of the best experimentally characterized for any protein. In spite of this, spectroscopic studies have…”
Get full text

Microsecond Subdomain Folding in Dihydrofolate Reductase by Arai, Munehito, Iwakura, Masahiro, Matthews, C. Robert, Bilsel, Osman

“…The characterization of microsecond dynamics in the folding of multisubdomain proteins has been a major challenge in understanding their often complex folding…”
Get full text

Modulation of frustration in folding by sequence permutation by Nobrega, R. Paul, Arora, Karunesh, Kathuria, Sagar V., Graceffa, Rita, Barrea, Raul A., Guo, Liang, Chakravarthy, Srinivas, Bilsel, Osman, Irving, Thomas C., Brooks, Charles L., Matthews, C. Robert

“…Folding of globular proteins can be envisioned as the contraction of a random coil unfolded state toward the native state on an energy surface rough with local…”
Get full text

Metal Deficiency Increases Aberrant Hydrophobicity of Mutant Superoxide Dismutases That Cause Amyotrophic Lateral Sclerosis by Tiwari, Ashutosh, Liba, Amir, Sohn, Se Hui, Seetharaman, Sai V., Bilsel, Osman, Matthews, C.Robert, Hart, P.John, Valentine, Joan Selverstone, Hayward, Lawrence J.

“…The mechanisms by which mutant variants of Cu/Zn-superoxide dismutase (SOD1) cause familial amyotrophic lateral sclerosis are not clearly understood. Evidence…”
Get full text

Metal-free ALS variants of dimeric human Cu,Zn-superoxide dismutase have enhanced populations of monomeric species by Svensson, Anna-Karin E, Bilsel, Osman, Kayatekin, Can, Adefusika, Jessica A, Zitzewitz, Jill A, Matthews, C Robert

“…Amino acid replacements at dozens of positions in the dimeric protein human, Cu,Zn superoxide dismutase (SOD1) can cause amyotrophic lateral sclerosis (ALS)…”
Get full text

Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells by Sainlos, Matthieu, Chitta, Sriram, Venkatraman, Prasanna, Imperiali, Barbara, Stern, Lawrence J, Bilsel, Osman, Nguyen, Tina T

“…A crucial step in the immune response is the binding of antigenic peptides to major histocompatibility complex (MHC) proteins. Class II MHC proteins present…”
Get full text

Heterogeneous folding and stretched kinetics by Bilsel, Osman

Get full text

Mapping the Folding Free Energy Surface for Metal-free Human Cu,Zn Superoxide Dismutase by Svensson, Anna-Karin E., Bilsel, Osman, Kondrashkina, Elena, Zitzewitz, Jill A., Matthews, C. Robert

“…Mutations at many different sites in the gene encoding human Cu,Zn superoxide dismutase (SOD) are known to be causative agents in amyotrophic lateral sclerosis…”
Get full text