Search Results - "Billy, Eric"

Open science saves lives: lessons from the COVID-19 pandemic by Besançon, Lonni, Peiffer-Smadja, Nathan, Segalas, Corentin, Jiang, Haiting, Masuzzo, Paola, Smout, Cooper, Billy, Eric, Deforet, Maxime, Leyrat, Clémence

“…Abstract In the last decade Open Science principles have been successfully advocated for and are being slowly adopted in different research communities. In…”
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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5 by Mavrakis, Konstantinos J., McDonald, E. Robert, Schlabach, Michael R., Billy, Eric, Hoffman, Gregory R., deWeck, Antoine, Ruddy, David A., Venkatesan, Kavitha, Yu, Jianjun, McAllister, Gregg, Stump, Mark, deBeaumont, Rosalie, Ho, Samuel, Yue, Yingzi, Liu, Yue, Yan-Neale, Yan, Yang, Guizhi, Lin, Fallon, Yin, Hong, Gao, Hui, Kipp, D. Randal, Zhao, Songping, McNamara, Joshua T., Sprague, Elizabeth R., Zheng, Bing, Lin, Ying, Cho, Young Shin, Gu, Justin, Crawford, Kenneth, Ciccone, David, Vitari, Alberto C., Lai, Albert, Capka, Vladimir, Hurov, Kristen, Porter, Jeffery A., Tallarico, John, Mickanin, Craig, Lees, Emma, Pagliarini, Raymond, Keen, Nicholas, Schmelzle, Tobias, Hofmann, Francesco, Stegmeier, Frank, Sellers, William R.

“…5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway. The MTAP gene is frequently deleted in human cancers because of…”
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CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions by Munoz, Diana M, Cassiani, Pamela J, Li, Li, Billy, Eric, Korn, Joshua M, Jones, Michael D, Golji, Javad, Ruddy, David A, Yu, Kristine, McAllister, Gregory, DeWeck, Antoine, Abramowski, Dorothee, Wan, Jessica, Shirley, Matthew D, Neshat, Sarah Y, Rakiec, Daniel, de Beaumont, Rosalie, Weber, Odile, Kauffmann, Audrey, McDonald, 3rd, E Robert, Keen, Nicholas, Hofmann, Francesco, Sellers, William R, Schmelzle, Tobias, Stegmeier, Frank, Schlabach, Michael R

“…CRISPR/Cas9 has emerged as a powerful new tool to systematically probe gene function. We compared the performance of CRISPR to RNAi-based loss-of-function…”
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The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity by Michaloglou, Chrysiis, Lehmann, Waltraut, Martin, Typhaine, Delaunay, Clara, Hueber, Andreas, Barys, Louise, Niu, Honglin, Billy, Eric, Wartmann, Markus, Ito, Moriko, Wilson, Christopher J, Digan, Mary Ellen, Bauer, Andreas, Voshol, Hans, Christofori, Gerhard, Sellers, William R, Hofmann, Francesco, Schmelzle, Tobias

“…The Hippo (Hpo) pathway is a novel signaling pathway that controls organ size in Drosophila and mammals and is deregulated in a variety of human cancers. It…”
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Correction of copy number induced false positives in CRISPR screens by de Weck, Antoine, Golji, Javad, Jones, Michael D, Korn, Joshua M, Billy, Eric, McDonald, 3rd, E Robert, Schmelzle, Tobias, Bitter, Hans, Kauffmann, Audrey

“…Cell autonomous cancer dependencies are now routinely identified using CRISPR loss-of-function viability screens. However, a bias exists that makes it…”
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The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis by Martiny-Baron, Georg, Holzer, Philipp, Billy, Eric, Schnell, Christian, Brueggen, Joseph, Ferretti, Mireille, Schmiedeberg, Niko, Wood, Jeanette M., Furet, Pascal, Imbach, Patricia

“…EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. In addition, several reports suggest…”
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Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization by LAMONTAGNE, Kenneth, LITTLEWOOD-EVANS, Amanda, BILLY, Eric, THEUER, Andreas, HLA, Timothy, WOOD, Jeanette, SCHNELL, Christian, O'REILLY, Terence, WYDER, Lorenza, SANCHEZ, Teresa, PROBST, Beatrice, BUTLER, Jeannene, WOOD, Alexander, LIAU, Gene

“…FTY720, a potent immunomodulator, becomes phosphorylated in vivo (FTY-P) and interacts with sphingosine-1-phosphate (S1P) receptors. Recent studies showed that…”
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Specific Interference with Gene Expression Induced by Long, Double-Stranded RNA in Mouse Embryonal Teratocarcinoma Cell Lines by Billy, Eric, Brondani, Vincent, Zhang, Haidi, Müller, Ulrich, Filipowicz, Witold

“…In eukaryotes, double-stranded (ds) RNA induces sequence-specific inhibition of gene expression, referred to as RNA interference (RNAi). In invertebrates, RNAi…”
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DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway by Dafflon, Caroline, Gaulis, Swann, Barys, Louise, Kapur, Karen, Cornacchione, Vanessa, Schukur, Lina, Bergling, Sebastian, Traggiai, Elisabetta, Jansky, Selina, Hellmann, Leon, Engstler, Barbara Schacher, Kerr, Grainne, de Weck, Antoine, Ruddy, David A, Naumann, Ulrike, Stauffer, Frédéric, Gaul, Christoph, Lin, Ying, Billy, Eric, Weiss, Andreas, Hofmann, Francesco, Ito, Moriko, Tiedt, Ralph

“…The histone 3 lysine 79 (H3K79) methyltransferase (HMT) DOT1L is known to play a critical role for growth and survival of -rearranged leukemia. Serendipitous…”
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Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor by Wyder, Lorenza, Suply, Thomas, Ricoux, Bérangère, Billy, Eric, Schnell, Christian, Baumgarten, Birgit U., Maira, Sauveur Michel, Koelbing, Claudia, Ferretti, Mireille, Kinzel, Bernd, Müller, Matthias, Seuwen, Klaus, Ludwig, Marie-Gabrielle

“…The G protein-coupled receptor GPR4 is activated by acidic pH and recent evidence indicates that it is expressed in endothelial cells. In agreement with these…”
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Raising concerns on questionable ethics approvals - a case study of 456 trials from the Institut Hospitalo-Universitaire Méditerranée Infection by Frank, Fabrice, Florens, Nans, Meyerowitz-Katz, Gideon, Barriere, Jérôme, Billy, Éric, Saada, Véronique, Samuel, Alexander, Robert, Jacques, Besançon, Lonni

“…The practice of clinical research is strictly regulated by law. During submission and review processes, compliance of such research with the laws enforced in…”
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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening by McDonald, E. Robert, de Weck, Antoine, Schlabach, Michael R., Billy, Eric, Mavrakis, Konstantinos J., Hoffman, Gregory R., Belur, Dhiren, Castelletti, Deborah, Frias, Elizabeth, Gampa, Kalyani, Golji, Javad, Kao, Iris, Li, Li, Megel, Philippe, Perkins, Thomas A., Ramadan, Nadire, Ruddy, David A., Silver, Serena J., Sovath, Sosathya, Stump, Mark, Weber, Odile, Widmer, Roland, Yu, Jianjun, Yu, Kristine, Yue, Yingzi, Abramowski, Dorothee, Ackley, Elizabeth, Barrett, Rosemary, Berger, Joel, Bernard, Julie L., Billig, Rebecca, Brachmann, Saskia M., Buxton, Frank, Caothien, Roger, Caushi, Justina X., Chung, Franklin S., Cortés-Cros, Marta, deBeaumont, Rosalie S., Delaunay, Clara, Desplat, Aurore, Duong, William, Dwoske, Donald A., Eldridge, Richard S., Farsidjani, Ali, Feng, Fei, Feng, JiaJia, Flemming, Daisy, Forrester, William, Galli, Giorgio G., Gao, Zhenhai, Gauter, François, Gibaja, Veronica, Haas, Kristy, Hattenberger, Marc, Hood, Tami, Hurov, Kristen E., Jagani, Zainab, Jenal, Mathias, Johnson, Jennifer A., Jones, Michael D., Kapoor, Avnish, Korn, Joshua, Liu, Jilin, Liu, Qiumei, Liu, Shumei, Liu, Yue, Loo, Alice T., Macchi, Kaitlin J., Martin, Typhaine, McAllister, Gregory, Meyer, Amandine, Mollé, Sandra, Pagliarini, Raymond A., Phadke, Tanushree, Repko, Brian, Schouwey, Tanja, Shanahan, Frances, Shen, Qiong, Stamm, Christelle, Stephan, Christine, Stucke, Volker M., Tiedt, Ralph, Varadarajan, Malini, Venkatesan, Kavitha, Vitari, Alberto C., Wallroth, Marco, Weiler, Jan, Zhang, Jing, Mickanin, Craig, Myer, Vic E., Porter, Jeffery A., Lai, Albert, Bitter, Hans, Lees, Emma, Keen, Nicholas, Kauffmann, Audrey, Stegmeier, Frank, Hofmann, Francesco, Schmelzle, Tobias, Sellers, William R.

“…Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant…”
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SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors by Lu, Hengyu, Liu, Chen, Velazquez, Roberto, Wang, Hongyun, Dunkl, Lukas Manuel, Kazic-Legueux, Malika, Haberkorn, Anne, Billy, Eric, Manchado, Eusebio, Brachmann, Saskia M, Moody, Susan E, Engelman, Jeffrey A, Hammerman, Peter S, Caponigro, Giordano, Mohseni, Morvarid, Hao, Huai-Xiang

“…FGFR1 was recently shown to be activated as part of a compensatory response to prolonged treatment with the MEK inhibitor trametinib in several KRAS-mutant…”
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Letter to Editor “Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs”: Important concerns on the validity of this article by Barrière, Jérôme, Frank, Fabrice, Besancon, Lonni, Samuel, Alexander, Saada, Véronique, Billy, Eric, Al-Ahmad, Abraham, Florens, Nans, Seitz-Polski, Barbara, Robert, Jacques

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Cluster headache after COVID-19 vaccination with Comirnaty: A signal in pharmacovigilance database by Rochoy, Michaël, Billy, Eric, Clarot, Franck, Dumortier, Victor, Gautier, Sophie, Barus, Romain

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Open science saves lives: lessons from the COVID-19 pandemic by Besançon, Lonni, Peiffer-Smadja, Nathan, Segalas, Corentin, Jiang, Haiting, Masuzzo, Paola, Smout, Cooper, Billy, Eric, Deforet, Maxime, Leyrat, Clémence

“…Abstract In the last decade Open Science principles have been successfully advocated for and are being slowly adopted in different research communities. In…”
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Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP by Zhang, Haidi, Kolb, Fabrice A., Brondani, Vincent, Billy, Eric, Filipowicz, Witold

“…Dicer is a multi‐domain RNase III‐related endonuclease responsible for processing double‐stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a…”
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Abstract A44: SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS-mutant tumors treated with MEK inhibitors by Lu, Hengyu, Liu, Chen, Velazquez, Roberto, Wang, Hongyun, Dunkl, Lukas M., Kazic-Legueux, Malika, Haberkorn, Anne, Billy, Eric, Manchado, Eusebio, Brachmann, Saskia M., Moody, Susan, Engelman, Jeffrey A., Hammerman, Peter S., Caponigro, Giordano, Mohseni, Morvarid, Hao, Huai-Xiang

“…Abstract FGFR1 was recently shown to be activated as part of a compensatory response to prolonged treatment with MEK inhibitor trametinib in several…”
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Abstract 954: SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS mutant tumors treated with MEK inhibitors by Lu, Hengyu, Liu, Chen, Velazquez, Roberto, Wang, Hongyun, Dunkl, Lukas M., Kazic-Legueux, Malika, Haberkorn, Anne, Billy, Eric, Manchado, Eusebio, Brachmann, Saskia M., Moody, Susan, Engelman, Jeffrey A., Hammerman, Peter S., Caponigro, Giordano, Mohseni, Morvarid, Hao, Huaixiang

“…Abstract Introduction: FGFR1 was recently shown to be activated as part of a compensatory response to prolonged treatment with MEK inhibitor (MEKi) such as…”
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Scientific Integrity Requires Publishing Rebuttals and Retracting Problematic Papers by Barrière, Jérôme, Frank, Fabrice, Besançon, Lonni, Samuel, Alexander, Saada, Véronique, Billy, Eric, Al-Ahmad, Abraham, Seitz-Polski, Barbara, Robert, Jacques

“…Recently, an article by Seneff et al. entitled "Innate immunosuppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs"…”
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