Search Results - "Billman, Zachary P"

NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patterns by Wei, Bo, Billman, Zachary P, Nozaki, Kengo, Goodridge, Helen S, Miao, Edward A

“…Inflammasomes are sensors that detect cytosolic microbial molecules or cellular damage, and in response they initiate a form of lytic regulated cell death…”
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An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2 by Harvest, Carissa K., Abele, Taylor J., Yu, Chen, Beatty, Cole J., Amason, Megan E., Billman, Zachary P., DePrizio, Morgan A., Souza, Fernando W., Lacey, Carolyn A., Maltez, Vivien I., Larson, Heather N., McGlaughon, Benjamin D., Saban, Daniel R., Montgomery, Stephanie A., Miao, Edward A.

“…Granulomas often form around pathogens that cause chronic infections. Here, we discover an innate granuloma model in mice with an environmental bacterium…”
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Beyond Blood Smears: Qualification of Plasmodium 18S rRNA as a Biomarker for Controlled Human Malaria Infections by Seilie, Annette M, Chang, Ming, Hanron, Amelia E, Billman, Zachary P, Stone, Brad C, Zhou, Kevin, Olsen, Tayla M, Daza, Glenda, Ortega, Jose, Cruz, Kurtis R, Smith, Nahum, Healy, Sara A, Neal, Jillian, Wallis, Carolyn K, Shelton, Lisa, Mankowski, Tracie VonGoedert, Wong-Madden, Sharon, Mikolajczak, Sebastian A, Vaughan, Ashley M, Kappe, Stefan H I, Fishbaugher, Matt, Betz, Will, Kennedy, Mark, Hume, Jen C C, Talley, Angela K, Hoffman, Stephen L, Chakravarty, Sumana, Sim, B Kim Lee, Richie, Thomas L, Wald, Anna, Plowe, Christopher V, Lyke, Kirsten E, Adams, Matthew, Fahle, Gary A, Cowan, Elliot P, Duffy, Patrick E, Kublin, James G, Murphy, Sean C

“…18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled human malaria infection (CHMI) trials. We reviewed data from CHMI…”
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Apoptotic signaling clears engineered Salmonella in an organ-specific manner by Abele, Taylor J, Billman, Zachary P, Li, Lupeng, Harvest, Carissa K, Bryan, Alexia K, Magalski, Gabrielle R, Lopez, Joseph P, Larson, Heather N, Yin, Xiao-Ming, Miao, Edward A

“…Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. When a cell fails to complete pyroptosis,…”
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Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo by Foquet, Lander, Schafer, Carola, Minkah, Nana K, Alanine, Daniel G W, Flannery, Erika L, Steel, Ryan W J, Sack, Brandon K, Camargo, Nelly, Fishbaugher, Matthew, Betz, Will, Nguyen, Thao, Billman, Zachary P, Wilson, Elizabeth M, Bial, John, Murphy, Sean C, Draper, Simon J, Mikolajczak, Sebastian A, Kappe, Stefan H I

“…The invention of liver-humanized mouse models has made it possible to directly study the preerythrocytic stages of . In contrast, the current models to…”
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Plasmodium vivax latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine by Flannery, Erika L., Kangwanrangsan, Niwat, Chuenchob, Vorada, Roobsoong, Wanlapa, Fishbaugher, Matthew, Zhou, Kevin, Billman, Zachary P., Martinson, Thomas, Olsen, Tayla M., Schäfer, Carola, Campo, Brice, Murphy, Sean C., Mikolajczak, Sebastian A., Kappe, Stefan H.I., Sattabongkot, Jetsumon

“…Plasmodium vivax is a malaria-causing pathogen that establishes a dormant form in the liver (the hypnozoite), which can activate weeks, months, or years after…”
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Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites by Douglass, Alyse N, Kain, Heather S, Abdullahi, Marian, Arang, Nadia, Austin, Laura S, Mikolajczak, Sebastian A, Billman, Zachary P, Hume, Jen C C, Murphy, Sean C, Kappe, Stefan H I, Kaushansky, Alexis

“…Eliminating malaria parasites during the asymptomatic but obligate liver stages (LSs) of infection would stop disease and subsequent transmission…”
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Complex Minigene Library Vaccination for Discovery of Pre-Erythrocytic Plasmodium T Cell Antigens by Stone, Brad C, Kas, Arnold, Billman, Zachary P, Fuller, Deborah H, Fuller, James T, Shendure, Jay, Murphy, Sean C

“…Development of a subunit vaccine targeting liver-stage Plasmodium parasites requires the identification of antigens capable of inducing protective T cell…”
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More time to kill: A longer liver stage increases T cell-mediated protection against pre-erythrocytic malaria by Yadav, Naveen, Parthiban, Chaitra, Billman, Zachary P., Stone, Brad C., Watson, Felicia N., Zhou, Kevin, Olsen, Tayla M., Cruz Talavera, Irene, Seilie, Annette Mariko, Kalata, Anya C., Matsubara, Jokichi, Shears, Melanie J., Reynolds, Rebekah A., Murphy, Sean C.

“…Liver stage (LS) Plasmodia mature in 2–2.5 days in rodents compared to 5–6 days in humans. Plasmodium-specific CD8+ T cell expansion differs across these…”
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Multiplex, DNase-free one-step reverse transcription PCR for Plasmodium 18S rRNA and spliced gametocyte-specific mRNAs by Hanron, Amelia E, Billman, Zachary P, Seilie, Annette M, Olsen, Tayla M, Fishbaugher, Matthew, Chang, Ming, Rueckle, Thomas, Andenmatten, Nicole, Greenhouse, Bryan, Arinaitwe, Emmanuel, Rek, John, Das, Smita, Domingo, Gonzalo J, Shipman, Kelly, Kappe, Stefan H, Kublin, James G, Murphy, Sean C

“…Plasmodium gametocytes are sexual stages transmitted to female Anopheles mosquitoes. While Plasmodium parasites can be differentiated microscopically on…”
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Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood by Murphy, Sean C, Ishizuka, Andrew S, Billman, Zachary P, Olsen, Tayla M, Seilie, Annette M, Chang, Ming, Smith, Nahum, Chuenchob, Vorada, Chakravarty, Sumana, Sim, B Kim Lee, Kappe, Stefan H I, Hoffman, Stephen L, Seder, Robert A

“…Plasmodium 18S rRNA is a biomarker used to monitor blood-stage infections in malaria clinical trials. Plasmodium sporozoites also express this biomarker, and…”
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Unanticipated Loss of Inflammasomes in Birds by Billman, Zachary P, Hancks, Dustin C, Miao, Edward A

“…Abstract Inflammasomes are multiprotein complexes that form in response to ligands originating from pathogens as well as alterations of normal cell physiology…”
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Overexpression of T3SS translocation signals in Salmonella causes delayed attenuation by Abele, Taylor J, Billman, Zachary P, Harvest, Carissa K, Bryan, Alexia K, Larson, Heather N, Coers, Jörn, Miao, Edward A

“…Engineering pathogens is a useful method for discovering new details of microbial pathogenesis and host defense. However, engineering can result in off-target…”
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Mass Spectrometry Identification of Biomarkers in Extracellular Vesicles From Plasmodium vivax Liver Hypnozoite Infections by Gualdrón-López, Melisa, Díaz-Varela, Miriam, Zanghi, Gigliola, Aparici-Herraiz, Iris, Steel, Ryan W.J., Schäfer, Carola, Cuscó, Pol, Chuenchob, Vorada, Kangwangransan, Niwat, Billman, Zachary P., Olsen, Tayla M., González, Juan R., Roobsoong, Wanlapa, Sattabongkot, Jetsumon, Murphy, Sean C., Mikolajczak, Sebastian A., Borràs, Eva, Sabidó, Eduard, Fernandez-Becerra, Carmen, Flannery, Erika L., Kappe, Stefan H.I., del Portillo, Hernando A.

“…Latent liver stages termed hypnozoites cause relapsing Plasmodium vivax malaria infection and represent a major obstacle in the goal of malaria elimination…”
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Purification of Plasmodium Sporozoites Enhances Parasite-Specific CD8+ T Cell Responses by Billman, Zachary P, Seilie, Annette M, Murphy, Sean C

“…Malaria infection caused by Plasmodium parasites continues to cause enormous morbidity and mortality in areas where it is endemic, and there is no licensed…”
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Detection of Babesia microti parasites by highly sensitive 18S rRNA reverse transcription PCR by Hanron, Amelia E, Billman, Zachary P, Seilie, Annette M, Chang, Ming, Murphy, Sean C

“…Abstract Babesia are increasingly appreciated as a cause of transfusion-transmitted infection. Sensitive methods are needed to screen blood products. We report…”
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Defining rules of CD8(+) T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized mice by Billman, Zachary P, Kas, Arnold, Stone, Brad C, Murphy, Sean C

“…Whole Plasmodium sporozoites serve as both experimental tools and potentially as deployable vaccines in the fight against malaria infection. Live sporozoites…”
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Human Diphyllobothrium nihonkaiense infection in Washington State by Fang, Ferric C, Billman, Zachary P, Wallis, Carolyn K, Abbott, April N, Olson, John C, Dhanireddy, Shireesha, Murphy, Sean C

“…A patient in Washington State harbored a fish tapeworm most likely acquired from eating raw salmon. Diphyllobothrium nihonkaiense was identified by cox1…”
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External quality assurance of malaria nucleic acid testing for clinical trials and eradication surveillance by Murphy, Sean C, Hermsen, Cornelus C, Douglas, Alexander D, Edwards, Nick J, Petersen, Ines, Fahle, Gary A, Adams, Matthew, Berry, Andrea A, Billman, Zachary P, Gilbert, Sarah C, Laurens, Matthew B, Leroy, Odile, Lyke, Kristen E, Plowe, Christopher V, Seilie, Annette M, Strauss, Kathleen A, Teelen, Karina, Hill, Adrian V S, Sauerwein, Robert W

“…Nucleic acid testing (NAT) for malaria parasites is an increasingly recommended diagnostic endpoint in clinical trials of vaccine and drug candidates and is…”
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Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice by Sack, Brandon K., Mikolajczak, Sebastian A., Fishbaugher, Matthew, Vaughan, Ashley M., Flannery, Erika L., Nguyen, Thao, Betz, Will, Jane Navarro, Mary, Foquet, Lander, Steel, Ryan W. J., Billman, Zachary P., Murphy, Sean C., Hoffman, Stephen L., Chakravarty, Sumana, Sim, B. Kim Lee, Behet, Marije, Reuling, Isaie J., Walk, Jona, Scholzen, Anja, Sauerwein, Robert W., Ishizuka, Andrew S., Flynn, Barbara, Seder, Robert A., Kappe, Stefan H. I.

“…A malaria vaccine that prevents infection will be an important new tool in continued efforts of malaria elimination, and such vaccines are under intense…”
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