Search Results - "Billi, A M"

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells by Papa, V, Tazzari, P L, Chiarini, F, Cappellini, A, Ricci, F, Billi, A M, Evangelisti, C, Ottaviani, E, Martinelli, G, Testoni, N, McCubrey, J A, Martelli, A M

“…The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase (PI3K), is known to play an important role in antiapoptotic signaling…”
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A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells by MARTELLI, A. M, TAZZARI, P. L, TABELLINI, G, BORTUL, R, BILLI, A. M, MANZOLI, L, RUGGERI, A, CONTE, R, COCCO, L

“…It is now well established that the reduced capacity of tumor cells of undergoing cell death through apoptosis plays a key role both in the pathogenesis of…”
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Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside by Martelli, A M, Tazzari, P L, Evangelisti, C, Chiarini, F, Blalock, W L, Billi, A M, Manzoli, L, McCubrey, J A, Cocco, L

“…The phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B, PKB)/mammalian Target Of Rapamycin (mTOR) signaling pathway plays a critical role in many…”
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Metabolism and signaling activities of nuclear lipids by Martelli, A M, Falà, F, Faenza, I, Billi, A M, Cappellini, A, Manzoli, L, Cocco, L

“…Apart from the lipids present in the nuclear envelope, the nucleus also contains lipids which are located further inside and are resistant to treatment with…”
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Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-κB activation and cFLIPL up-regulation by BORTUL, R, TAZZARI, P. L, CAPPELLINI, A, TABELLINI, G, BILLI, A. M, BAREGGI, R, MANZOLI, L, COCCO, L, MARTELL, A. M

“…TRAIL is a member of the tumor necrosis factor superfamily which induces apoptosis in cancer but not in normal cells. Akt1 promotes cell survival and blocks…”
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The anatomy of the pelvic plexus in female cadavers: implications for retroperitoneal nerve-sparing surgery by Mastronardi, M, Raimondo, D, Mabrouk, M, Raffone, A, Giorgi, M, Centini, G, Zupi, E, Seracchioli, R, Maletta, M, Ratti, S, O'guin, W M, Manzoli, L, Billi, A M

“…The inferior hypogastric plexus (IHP) is a crucial structure for female continence and sexual function. A nerve-sparing approach should be pursued to reduce…”
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Nuclear protein kinase C isoforms: key players in multiple cell functions? by Martelli, A M, Faenza, I, Billi, A M, Falà, F, Cocco, L, Manzoli, L

“…Protein kinase C (PKC) isozymes are a family of serine/threonine protein kinases categorized into three subfamilies: classical, novel, and atypical. PKC…”
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Involvement of the phosphoinositide 3-kinase/Akt signaling pathway in the resistance to therapeutic treatments of human leukemias by Martelli, A M, Tabellini, G, Bortul, R, Tazzari, P L, Cappellini, A, Billi, A M, Cocco, L

“…A major factor undermining successful cancer treatment is the occurrence of resistance to conventional treatments such as chemotherapy and ionizing radiation…”
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The phosphoinositide 3-kinase/akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27kip1 and control of cyclin D1 expression by CAPPELLINI, A, TABELLINI, G, ZWEYER, M, BORTUL, R, TAZZARI, P. L, BILLI, A. M, FALA, F, COCCO, L, MARTELLI, A. M

“…The serine/threonine protein kinase Akt, a downstream effector of phosphoinositide 3-kinase (PI3K), plays a pivotal role in tumorigenesis because it affects…”
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Phosphoinositide signaling in nuclei of friend cells : phospholipase C β Down-regulation is related to cell differentiation by MARTELLI, A. M, BILLI, A. M, GILMOUR, R. S, NERI, L. M, MANZOLI, L, OGNIBENE, A, COCCO, L

“…Previous investigations have demonstrated the existence of an autonomous intranuclear inositide cycle endowed with conventional lipid kinases and phospholipase…”
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The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression by Cappellini, A, Tabellini, G, Zweyer, M, Bortul, R, Tazzari, P L, Billi, A M, Falà, F, Cocco, L, Martelli, A M

“…The serine/threonine protein kinase Akt, a downstream effector of phosphoinositide 3-kinase (PI3K), plays a pivotal role in tumorigenesis because it affects…”
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Tiazofurin-induced changes in inositol lipid cycle in nuclei of Friend erythroleukemia cells by Billi, A M, Cocco, L, Martelli, A M, Gilmour, R S, Weber, G

“…When murine erythroleukemia cells are treated up to 96 hrs with the antitumor drug tiazofurin the induction of erythroid differentiation is accompanied by…”
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Nuclear phospholipase C: a novel aspect of phosphoinositide signalling by Manzoli, L, Billi, A M, Faenza, I, Matteucci, A, Martelli, A M, Peruzzi, D, Falconi, M, Rhee, S G, Gilmour, R S, Cocco, L

“…The role of polyphosphoinositides in cellular signalling is well known and recently it has also been shown that the nucleus is a site for both synthesis and…”
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Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells by Vitale, M, Matteucci, A, Manzoli, L, Rodella, L, Mariani, A R, Zauli, G, Falconi, M, Billi, A M, Martelli, A M, Gilmour, R S, Cocco, L

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Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation by Cappellini, A, Tazzari, P L, Mantovani, I, Billi, A M, Tassi, C, Ricci, F, Conte, R, Martelli, A M

“…A combination of 8-methoxypsoralen and ultraviolet-A radiation (320-400 nm) (PUVA) is used for the treatment of T cell-mediated disorders, including chronic…”
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Nuclear inositol lipid cycle: a new central intermediary in signal transduction by Manzoli, L, Gilmour, R S, Martelli, A M, Billi, A M, Cocco, L

“…The involvement of phospholipids and especially polyphosphoinositides in cellular signalling has been documented in detail over the last 20 years. Besides the…”
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Age-related events in human active T lymphocytes: changes in the phosphoinositidase C activity by Di Pietro, R, Rana, R A, Sciscio, A, Marmiroli, S, Billi, A M, Cataldi, A, Cocco, L

“…Since PHA-stimulated active T lymphocytes from aged humans showed changes in the metabolic pattern of inositol lipids in comparison with young subjects, we…”
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The protein composition of Friend cell nuclear matrix stabilized by various treatments. Different recovery of nucleolar proteins B23 and C23 and nuclear lamins by Martelli, A M, Manzoli, L, Rubbini, S, Billi, A M, Bareggi, R, Cocco, L

“…Using two-dimensional polyacrylamide gels stained with Coomassie blue we have studied the protein composition of the nuclear matrix obtained from mouse…”
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Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1) by Peruzzi, D, Calabrese, G, Faenza, I, Manzoli, L, Matteucci, A, Gianfrancesco, F, Billi, A M, Stuppia, L, Palka, G, Cocco, L

“…Members of phosphoinositide-specific phospholipase C (PLC) families are central intermediary in signal transduction in response to the occupancy of receptors…”
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Liposome-nucleus interactions. Flow cytometric study on the role of the nuclear surface by Caramelli, E, Papa, S, Billi, A M, Vitale, M, Bartoletti, A, Manzoli, L, Capitani, S

“…The water-soluble probe carboxyfluorescein (CF), contained in the internal aqueous phase of liposomes, was used to investigate the interaction of phospholipid…”
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