Search Results - "Billard, Matthew"

G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis by Billard, Matthew J, Fitzhugh, David J, Parker, Joel S, Brozowski, Jaime M, McGinnis, Marcus W, Timoshchenko, Roman G, Serafin, D Stephen, Lininger, Ruth, Klauber-Demore, Nancy, Sahagian, Gary, Truong, Young K, Sassano, Maria F, Serody, Jonathan S, Tarrant, Teresa K

“…Triple negative breast cancer (TNBC) is a heterogeneous disease that has a poor prognosis and limited treatment options. Chemokine receptor interactions are…”
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Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses by Billard, Matthew J, Gruver, Amanda L, Sempowski, Gregory D

“…Productive thymopoiesis is essential for a robust and healthy immune system. Thymus unfortunately is acutely sensitive to stress resulting in involution and…”
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Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages by Serafin, D. Stephen, Allyn, Brittney, Sassano, Maria F., Timoshchenko, Roman G., Mattox, Daniel, Brozowski, Jaime M., Siderovski, David P., Truong, Young K., Esserman, Denise, Tarrant, Teresa K., Billard, Matthew J.

“…•A model for CMKLR1 receptor regulation on inflammatory macrophages is proposed.•GRK6 helps recruit β-arrestin 2 to CMKLR1 after chemerin stimulation.•CMKLR1…”
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G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses by Tarrant, Teresa K., Billard, Matthew J., Timoshchenko, Roman G., McGinnis, Marcus W., Serafin, D. Stephen, Foreman, Oded, Esserman, Denise A., Chao, Nelson J., Lento, William E., Lee, David M., Patel, Dhavalkumar, Siderovski, David P.

“…GRK3−/− mice exhibit impaired CXCL12/CXCR4 responses, myelokathexis and hypogammaglobulinemia, as in WHIM syndrome, and are protected in inflammatory arthritis…”
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G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation by Brozowski, Jaime M, Timoshchenko, Roman G, Serafin, D Stephen, Allyn, Brittney, Koontz, Jessica, Rabjohns, Emily M, Rampersad, Rishi R, Ren, Yinshi, Eudy, Amanda M, Harris, Taylor F, Abraham, David, Mattox, Daniel, Rubin, Clinton T, Hilton, Matthew J, Rubin, Janet, Allbritton, Nancy L, Billard, Matthew J, Tarrant, Teresa K

“…The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the…”
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G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis by Giguère, Patrick M., Billard, Matthew J., Laroche, Geneviève, Buckley, Brian K., Timoshchenko, Roman G., McGinnis, Marcus W., Esserman, Denise, Foreman, Oded, Liu, Peng, Siderovski, David P., Tarrant, Teresa K.

“…► GPSM3 is highly expressed in mature monocytes. ► GPSM3-deficient monocytes have decreased chemotaxis to CCL2, CX3CL1, and chemerin. ► GPSM3-deficient THP-1…”
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Interrogating Genetic Susceptibility Loci in CVID and Autoimmunity by Yang, Luanna, Shah, Shaili N., MD, Serafin, D Stephen, Timoshchenko, Roman G, Scotland, Paula, Richards, Kristy, Billard, Matthew J, Lugar, Patricia L., MD, MS, Tarrant, Teresa K., MD, FAAAAI

“…[...]we hypothesized that possessing the allele may correlate with decreased autoimmunity in CVID…”
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Targeting the Molecular and Cellular Interactions of the Bone Marrow Niche in Immunologic Disease by Brozowski, Jaime M., Billard, Matthew J., Tarrant, Teresa K.

“…Recent investigations have expanded our knowledge of the regulatory bone marrow (BM) niche, which is critical in maintaining and directing hematopoietic stem…”
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Co-engagement of alpha(4)beta(1) integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells by Kim, Tae Kon, Billard, Matthew J, Wieder, Eric D, McIntyre, Bradley W, Komanduri, Krishna V

“…The alpha(4)beta(1) integrin VLA-4 (very-late activation antigen-4) and the lineage-specific CD4 and CD8 receptors have been proposed as putative…”
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G protein signaling modulator-3: a leukocyte regulator of inflammation in health and disease by Billard, Matthew J, Gall, Bryan J, Richards, Kristy L, Siderovski, David P, Tarrant, Teresa K

“…G protein signaling modulator-3 (GPSM3), also known as G18 or AGS4, is a member of a family of proteins containing one or more copies of a small regulatory…”
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CD45RA T-cell activation without proliferation by a partial agonist monoclonal antibody to β1 integrin by Billard, Matthew J, McIntyre, Bradley W

“…CD45RA T cells are fully co‐activated by natural β1 integrin ligands fibronectin (FN) and VCAM‐1, as well as monoclonal antibody (mAb) 19H8, which binds a…”
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Computer simulation of lymphocyte traffic through the homeostatic lymph node (102.14) by Billard, Matthew, Kepler, Thomas

“…Lymphocytes recognize their rare cognate antigens within the complex microenvironment of secondary lymphoid organs (SLO). Proper lymphocyte migration into,…”
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Diverse roles of integrins in human T lymphocyte biology by Miyamoto, Yuko J, Andruss, Bernard F, Mitchell, Jason S, Billard, Matthew J, McIntyre, Bradley W

“…T lymphocytes are the primary cells responsible for maintaining the immune system. There are many intricate mechanisms involved in the regulation of T cells…”
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Acute stress-induced thymic atrophy is mediated by intrathymic inflammatory and wound healing responses (113.25) by Billard, Matthew, Gruver, Amanda, Sempowski, Gregory

“…Productive thymopoiesis is essential for a robust and healthy immune system. Thymus unfortunately is acutely sensitive to stress resulting in involution and…”
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G Protein-Coupled Receptor Kinase-3 (GRK-3) In Bone Marrow Niche Interactions and Transplantation by Brozowski, Jaime M, Timoshchenko, Roman, Koontz, Jessica, Rubin, Janet, Billard, Matthew, Tarrant, Teresa K

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A Model for Migratory B Cell Oscillations from Receptor Down-Regulation Induced by External Chemokine Fields by Chan, Cliburn, Billard, Matthew, Ramirez, Samuel A., Schmidl, Harald, Monson, Eric, Kepler, Thomas B.

“…A long-standing paradigm in B cell immunology is that effective somatic hypermutation and affinity maturation require cycling between the dark zone and light…”
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Co-engagement of α4β1 integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells by Kim, Tae Kon, Billard, Matthew J., Wieder, Eric D., McIntyre, Bradley W., Komanduri, Krishna V.

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CD45RA T-cell activation without proliferation by a partial agonist monoclonal antibody to [beta]1 integrin by Billard, Matthew J, Mcintyre, Bradley W

“…CD45RA T cells are fully co-activated by natural β1 integrin ligands fibronectin (FN) and VCAM-1, as well as monoclonal antibody (mAb) 19H8, which binds a…”
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CD45RA T-cell activation without proliferation by a partial agonist monoclonal antibody to beta1 integrin by Billard, Matthew J, McIntyre, Bradley W

“…CD45RA T cells are fully co-activated by natural beta1 integrin ligands fibronectin (FN) and VCAM-1, as well as monoclonal antibody (mAb) 19H8, which binds a…”
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Contrasting Roles for Domain 4 of VCAM-1 in the Regulation of Cell Adhesion and Soluble VCAM-1 Binding to Integrin α4β1 by Woodside, Darren G., Kram, Ronda M., Mitchell, Jason S., Belsom, Tracie, Billard, Matthew J., McIntyre, Bradley W., Vanderslice, Peter

“…Cell adhesion mediated by the interaction between integrin α4β1 and VCAM-1 is important in normal physiologic processes and in inflammatory and autoimmune…”
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