Search Results - "Billah, Motasim M"

A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation by Chapman, Richard W, Minnicozzi, Michael, Celly, Chander S, Phillips, Jonathan E, Kung, Ted T, Hipkin, R William, Fan, Xuedong, Rindgen, Diane, Deno, Gregory, Bond, Richard, Gonsiorek, Waldemar, Billah, Motasim M, Fine, Jay S, Hey, John A

“…Sch527123 [2-hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]ben-zamide] is a potent, selective…”
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Effects of Chronic Anti-Interleukin-5 Monoclonal Antibody Treatment in a Murine Model of Pulmonary Inflammation by Garlisi, Charles G, Kung, Ted T, Wang, Peng, Minnicozzi, Michael, Umland, Shelby P, Chapman, Richard W, Stelts, Dawn, Crawley, Yvette, Falcone, Angela, Myers, Joyce G, Jones, Howard, Motasim Billah, M, Kreutner, William, Egan, Robert W

“…The maturation of eosinophils in bone marrow, their migration to pulmonary tissue, and their subsequent degranulation and release of toxic granule proteins…”
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Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor by Billah, M Motasim, Cooper, Nicola, Minnicozzi, Michael, Warneck, Julie, Wang, Peng, Hey, John A, Kreutner, William, Rizzo, Charles A, Smith, Sidney R, Young, Simon, Chapman, Richard W, Dyke, Hazel, Shih, Nang-Yang, Piwinski, John J, Cuss, Francis M, Montana, John, Ganguly, Ashit K, Egan, Robert W

“…N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591) has been identified as a potent (IC(50) = 58 nM) and…”
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A Unique mRNA Initiated within a Middle Intron of WHSC1/MMSET Encodes a DNA Binding Protein That Suppresses Human IL-5 Transcription by Garlisi, Charles G, Uss, Annette Schettino, Xiao, Hong, Tian, Fang, Sheridan, Kristine E, Wang, Luquan, Motasim Billah, M, Egan, Robert W, Stranick, Kimberly S, Umland, Shelby P

“…Human interleukin (IL)-5 gene transcription is regulated by several transcription factor binding sites, including CLE 0, GATA, and a region from position -123…”
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Interleukin-5 mRNA Stability in Human T Cells Is Regulated Differently than Interleukin-2, Interleukin-3, Interleukin-4, Granulocyte/Macrophage Colony-stimulating Factor, and Interferon-gamma by Umland, Shelby P, Razac, Shad, Shah, Himanshu, Kyle Nahrebne, D, Egan, Robert W, Motasim Billah, M

“…Interleukin-5 (IL-5) transcriptional activation and mRNA stability were investigated in a human TH0 T-cell clone (SP-B21) and in nonclonal CD4 TH2 cells,…”
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Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5): Differential tissue distribution and subcellular localization of PDE9A variants by Wang, Peng, Wu, Ping, Egan, Robert W., Billah, M.Motasim

“…Previously, four splice variants of human cGMP-specific phosphodiesterase (PDE) 9A (PDEs 9A1, 9A2, 9A3 and 9A4) have been identified. In this study, we have…”
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Receptor reserve analysis of the human CCR3 receptor in eosinophils and CCR3-transfected cells by Umland, Shelby P., Wan, Yuntao, Shortall, Jennifer, Shah, Himanshu, Jakway, James, Garlisi, Charles G., Tian, Fang, Egan, Robert W., Billah, M. Motasim

“…A novel pharmacological study of CCR3 receptor reserve in a CCR3‐transfected cell (CREM3) and human eosinophils was done; functional responses measured were…”
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Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils by Wang, P, Wu, P, Ohleth, K M, Egan, R W, Billah, M M

“…The type 4 phosphodiesterase (PDE4) is the predominant PDE isozyme in various leukocytes and plays a key role in the regulation of inflammatory cell…”
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Effects of Cyclosporin A and Dinactin on T-Cell Proliferation, Interleukin-5 Production, and Murine Pulmonary Inflammation by Umland, Shelby P, Shah, Himanshu, Jakway, James P, Shortall, Jennifer, Razac, Shad, Garlisi, Charles G, Falcone, Angela, Kung, Ted T, Stelts, Dawn, Hegde, Vinod, Patel, M, Motasim Billah, M, Egan, Robert W

“…We compared the effects of cyclosporin A (CSA) and a macrotetrolide antibiotic, dinactin, on human T-cell proliferation and cytokine production induced by…”
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Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor by Wang, Peng, Zhang, Ji, Bian, Hong, Wu, Ping, Kuvelkar, Reshma, Kung, Ted T, Crawley, Yvette, Egan, Robert W, Billah, M Motasim

“…Among the three isoenzymes of neuraminidase (Neu) or sialidase, Neu-1 has been suggested to be induced by cell activation and to be involved in IL…”
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Human ADAM33: protein maturation and localization by Garlisi, Charles G, Zou, Jun, Devito, Kristine E, Tian, Fang, Zhu, Feng X, Liu, Jianjun, Shah, Himanshu, Wan, Yuntao, Motasim Billah, M, Egan, Robert W, Umland, Shelby P

“…ADAM33 (a disintegrin and metalloprotease) was recently found to be a novel asthma susceptibility gene [18]. Domain-specific antibodies were used to study its…”
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The inhibitory effects of topically active glucocorticoids on IL-4, IL-5, and interferon-γ production by cultured primary CD4 + T cells by Umland, Shelby P., Nahrebne, D.Kyle, Razac, Shad, Beavis, Andrew, Pennline, Kenneth J., Egan, Robert W., Billah, M.Motasim

“…This study was conducted to directly compare the in vitro efficacy and potency of several glucocorticoids in inhibiting T-cell cytokine production. The…”
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Phosphodiesterase 4B gene transcription is activated by lipopolysaccharide and inhibited by interleukin-10 in human monocytes by Ma, D, Wu, P, Egan, R W, Billah, M M, Wang, P

“…There are four different genes encoding the cAMP-specific phosphodiesterase (PDE4) isozymes (A, B, C, and D). cAMP has been the only agent known to induce PDE4…”
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Differential inhibitor sensitivity between human recombinant and native photoreceptor cGMP-phosphodiesterases (PDE6s) by Zhang, Ji, Kuvelkar, Reshma, Wu, Ping, Egan, Robert W, Billah, M.Motasim, Wang, Peng

“…Human photoreceptor cGMP-phosphodiesterases (PDE6s) are important reagents in PDE inhibitor discovery. However, recombinant human PDE6s have not been…”
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Identification of full, partial and inverse CC chemokine receptor 3 agonists using [ 35S]GTPγS binding by Wan, Yuntao, Jakway, James P, Qiu, Hongchen, Shah, Himanshu, Garlisi, Charles G, Tian, Fang, Ting, Pauline, Hesk, David, Egan, R.W, Billah, M.Motasim, Umland, Shelby P

“…Study of the CC chemokine receptor 3 (CCR3) has been limited to using radiolabeled agonist chemokines. A small molecule CCR3 antagonist,…”
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Mapping and characterization of the epitope(s) of Sch 55700, a humanized mAb, that inhibits human IL-5 by Zhang, Ji, Kuvelkar, Reshma, Murgolo, Nicholas J., Taremi, S. Shane, Chou, Chuan-Chu, Wang, Peng, Billah, Motasim M., Egan, Robert W.

“…mAb against human IL-5 inhibit pulmonary eosinophilia, tissue damage and airway hyper-reactivity in allergic animal models. Sch 55700 is a humanized,…”
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Differential plasma duration of antiplatelet-activating factor and antihistamine activities of oral Sch 37370 in humans by Billah, M M, Gilchrest, H G, Eckel, S P, Granzow, C A, Lawton, P J, Radwanski, E, Brannan, M D, Affrime, M B, Christopher, J D, Richards, W

“…Preclinical studies have established that Sch 37370 (1-acetyl-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]-cyclohepta [1,2-b]pyridin-11-ylidene)piperidine) is an…”
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Identification of Transcription Factor Binding Sites Important in the Regulation of the Human Interleukin-5 Gene by Stranick, Kimberly S., Zambas, Demetris N., Uss, Annette Schettino, Egan, Robert W., Billah, M. Motasim, Umland, Shelby P.

“…This study identifies three regions of the human interleukin (IL)-5 promoter involved in binding nuclear factors from activated T cells. DNase I footprinting…”
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Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme by PENG WANG, ANTHES, J. C, SIEGEL, M. I, EGAN, R. W, MOTASIM BILLAH, M

“…In a wide variety of cells, phosphatidylcholine hydrolysis in response to diverse agents is catalyzed by phospholipase D (PLD) activities that are believed to…”
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Airway Eosinophils, T Cells, Th2-Type Cytokine mRNA, and Hyperreactivity in Response to Aerosol Challenge of Allergic Mice with Previously Established Pulmonary Inflammation by Garlisi, Charles G, Falcone, Angela, Hey, John A, Paster, Theresa M, Fernandez, Xiomara, Rizzo, Charles A, Minnicozzi, Michael, Jones, Howard, Motasim Billah, M, Egan, Robert W, Umland, Shelby P

“…Asthma is characterized by acute episodes of nonspecific airway hyperreactivity and chronic pulmonary inflammation exacerbated by stimuli including allergen…”
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