Search Results - "Bill, Matthew"

PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension by Hennigs, Jan K., Cao, Aiqin, Li, Caiyun G., Shi, Minyi, Mienert, Julia, Miyagawa, Kazuya, Körbelin, Jakob, Marciano, David P., Chen, Pin-I, Roughley, Matthew, Elliott, Matthew V., Harper, Rebecca L., Bill, Matthew A., Chappell, James, Moonen, Jan-Renier, Diebold, Isabel, Wang, Lingli, Snyder, Michael P., Rabinovitch, Marlene

“…In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative vascular disease are associated with DNA damage and impaired signaling of…”
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PRMT5 Is Upregulated in Malignant and Metastatic Melanoma and Regulates Expression of MITF and p27Kip1 by Nicholas, Courtney, Yang, Jennifer, Peters, Sara B., Bill, Matthew A., Baiocchi, Robert A., Yan, Fengting, Sïf, Saïd, Tae, Sookil, Gaudio, Eugenio, Wu, Xin, Grever, Michael R., Young, Gregory S., Lesinski, Gregory B.

“…Protein arginine methyltransferase-5 (PRMT5) is a Type II arginine methyltransferase that regulates various cellular functions. We hypothesized that PRMT5…”
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Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension by Spiekerkoetter, Edda, Sung, Yon K, Sudheendra, Deepti, Bill, Matthew, Aldred, Micheala A, van de Veerdonk, Mariëlle C, Vonk Noordegraaf, Anton, Long-Boyle, Janel, Dash, Rajesh, Yang, Phillip C, Lawrie, Allan, Swift, Andrew J, Rabinovitch, Marlene, Zamanian, Roham T

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Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells by Yang, Jennifer, Bill, Matthew A, Young, Gregory S, La Perle, Krista, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Senapedis, William, Kashyap, Trinayan, Saint-Martin, Jean-Richard, Kendra, Kari, Lesinski, Gregory B

“…XPO1/CRM1 is a key nuclear exporter protein that mediates translocation of numerous cellular regulatory proteins. We investigated whether XPO1 is a potential…”
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PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.) by Nicholas, Courtney, Yang, Jennifer, Peters, Sara B, Bill, Matthew A, Baiocchi, Robert A, Yan, Fengting, Sïf, Saïd, Tae, Sookil, Gaudio, Eugenio, Wu, Xin, Grever, Michael R, Young, Gregory S, Lesinski, Gregory B

“…Protein arginine methyltransferase-5 (PRMT5) is a Type II arginine methyltransferase that regulates various cellular functions. We hypothesized that PRMT5…”
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The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity by Bill, Matthew A, Fuchs, James R, Li, Chenglong, Yui, Jennifer, Bakan, Courtney, Benson, Jr, Don M, Schwartz, Eric B, Abdelhamid, Dalia, Lin, Jiayuh, Hoyt, Dale G, Fossey, Stacey L, Young, Gregory S, Carson, 3rd, William E, Li, Pui-Kai, Lesinski, Gregory B

“…We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this…”
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Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension by Tojais, Nancy F, Cao, Aiqin, Lai, Ying-Ju, Wang, Lingli, Chen, Pin-I, Alcazar, Miguel A Alejandre, de Jesus Perez, Vinicio, Hopper, Rachel K, Rhodes, Christopher J, Bill, Matthew A, Sakai, Lynn Y, Rabinovitch, Marlene

“…OBJECTIVE—We determined in patients with pulmonary arterial (PA) hypertension (PAH) whether in addition to increased production of elastase by PA smooth muscle…”
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Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines by Bill, Matthew A, Nicholas, Courtney, Mace, Thomas A, Etter, Jonathan P, Li, Chenglong, Schwartz, Eric B, Fuchs, James R, Young, Gregory S, Lin, Li, Lin, Jiayuh, He, Lei, Phelps, Mitch, Li, Pui-Kai, Lesinski, Gregory B

“…The Janus kinase-2 (Jak2)-signal transducer and activator of transcription-3 (STAT3) pathway is critical for promoting an oncogenic and metastatic phenotype in…”
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Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4+ T cells from patients with GI malignancy by Mundy-Bosse, Bethany L., Young, Gregory S., Bauer, Todd, Binkley, Elaine, Bloomston, Mark, Bill, Matthew A., Bekaii-Saab, Tanios, Carson, William E., Lesinski, Gregory B.

“…Interferon-alpha (IFN-α) promotes anti-tumor immunity through its actions on immune cells. We hypothesized that elevated percentages of myeloid-derived…”
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Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines by Bill, Matthew A, Bakan, Courtney, Benson, Jr, Don M, Fuchs, James, Young, Gregory, Lesinski, Gregory B

“…Curcumin has potential as a chemopreventative and chemotherapeutic agent, but its interactions with clinically relevant cytokines are poorly characterized…”
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Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells by Lesinski, Gregory B, Zimmerer, Jason M, Kreiner, Melanie, Trefry, John, Bill, Matthew A, Young, Gregory S, Becknell, Brian, Carson, 3rd, William E

“…Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced…”
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UV Light B–Mediated Inhibition of Skin Catalase Activity Promotes Gr-1+CD11b+ Myeloid Cell Expansion by Sullivan, Nicholas J., Tober, Kathleen L., Burns, Erin M., Schick, Jonathan S., Riggenbach, Judith A., Mace, Thomas A., Bill, Matthew A., Young, Gregory S., Oberyszyn, Tatiana M., Lesinski, Gregory B.

“…Skin cancer incidence and mortality are higher in men compared with women, but the causes of this sex discrepancy remain largely unknown. UV light exposure…”
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Analysis of wear asymmetry in a series of 94 retrieved polyethylene tibial bearings by Currier, John H., Bill, Matthew A., Mayor, Michael B.

“…Knee joint kinematics is the focus of a significant amount of experimental study for the purpose of knee prosthesis design and for testing the wear of current…”
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Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension by Spiekerkoetter, Edda, Sung, Yon K, Sudheendra, Deepti, Scott, Valerie, Del Rosario, Patricia, Bill, Matthew, Haddad, Francois, Long-Boyle, Janel, Hedlin, Haley, Zamanian, Roham T

“…Pulmonary arterial hypertension (PAH) is a devastating disease characterised by occlusive pulmonary vasculopathy. Activation of bone morphogenetic protein…”
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Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension by Saito, Toshie, Miyagawa, Kazuya, Chen, Shih-Yu, Tamosiuniene, Rasa, Wang, Lingli, Sharpe, Orr, Samayoa, Erik, Harada, Daisuke, Moonen, Jan-Renier A.J, Cao, Aiqin, Chen, Pin-I, Hennigs, Jan K, Gu, Mingxia, Li, Caiyun G, Leib, Ryan D, Li, Dan, Adams, Christopher M, del Rosario, Patricia A, Bill, Matthew, Haddad, Francois, Montoya, Jose G, Robinson, William H, Fantl, Wendy J, Nolan, Garry P, Zamanian, Roham T, Nicolls, Mark R, Chiu, Charles Y, Ariza, Maria E, Rabinovitch, Marlene

“…BACKGROUND:Immune dysregulation has been linked to occlusive vascular remodeling in pulmonary arterial hypertension (PAH) that is hereditary, idiopathic, or…”
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Circulating plasmablasts are elevated and produce pathogenic anti‐endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension by Blum, Lisa K., Cao, Richard R.L., Sweatt, Andrew J., Bill, Matthew, Lahey, Lauren J., Hsi, Andrew C., Lee, Casey S., Kongpachith, Sarah, Ju, Chia‐Hsin, Mao, Rong, Wong, Heidi H., Nicolls, Mark R., Zamanian, Roham T., Robinson, William H.

“…Idiopathic pulmonary arterial hypertension (IPAH) is a devastating pulmonary vascular disease in which autoimmune and inflammatory phenomena are implicated. B…”
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Co-dependence of BMPR2 and TGFβ in Elastic Fiber Assembly and its Perturbation in Pulmonary Arterial Hypertension by Tojais, Nancy F., Cao, Aiqin, Lai, Ying-Ju, Wang, Lingli, Chen, Pin-I, Alcazar, Miguel A. Alejandre, Perez, Vinicio de Jesus, Hopper, Rachel K., Rhodes, Christopher J., Bill, Matthew A., Sakai, Lynn Y., Rabinovitch, Marlene

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Upregulation of HERV-K is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension by Saito, Toshie, Miyagawa, Kazuya, Chen, Shih-Yu, Tamosiuniene, Rasa, Wang, Lingli, Sharpe, Orr, Samayoa, Erik, Harada, Daisuke, Moonen, Jan-Renier A. J., Cao, Aiqin, Chen, Pin-I, Hennigs, Jan K., Gu, Mingxia, Li, Caiyun G., Leib, Ryan D., Li, Dan, Adams, Christopher M., del Rosario, Patricia A., Bill, Matthew, Haddad, Francois, Montoya, Jose G., Robinson, William H., Fantl, Wendy J., Nolan, Garry P., Zamanian, Roham T., Nicolls, Mark R., Chiu, Charles Y., Ariza, Maria E., Rabinovitch, Marlene

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Abstract 3443: Novel small molecule CRM1 inhibitors induce nuclear accumulation of p53, phosphorylated ERK and apoptosis in human melanoma cells by Yang, Jennifer, Bill, Matthew A., Young, Gregory S., Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Senapedis, William, Kashyap, Trinayan, Saint-Martin, Jean-Richard, Lesinski, Gregory

“…Abstract Inhibition of nuclear export can promote re-activation of tumor suppressor proteins (TSPs) by restoring them to the nucleus. CRM1 (chromosome region…”
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Abstract 162: Reduced pro-inflammatory cytokines and immunosuppressive cells in patients with prostate cancer following consumption of soy isoflavone enriched bread by Lesinski, Gregory Brian, Mace, Thomas A., Reville, Patrick, Ahn-Jarvis, Jennifer, Bill, Matthew, Nicholas, Courtney, Vodovotz, Yael, Grainger, Elizabeth, Riedl, Kenneth, Young, Gregory, Schwartz, Steven, Clinton, Steven

“…Abstract Soybeans are a rich source of bioactive phytochemcials. Among the phytochemicals, the isoflavones (primarily genistein and daidzein) have received the…”
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