Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep

Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep

Rapid eye movements (REM) are characteristic of the eponymous phase of sleep, yet the underlying motor commands remain an enigma. Here, we identified a cluster of Calbindin-D28K-expressing neurons in the Nucleus papilio (NP Calb ), located in the dorsal paragigantocellular nucleus, which are active...

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Bibliographic Details
Published in:Nature communications Vol. 10; no. 1; pp. 5225 - 11
Main Authors: Gutierrez Herrera, C., Girard, F., Bilella, A., Gent, T. C., Roccaro-Waldmeyer, D. M., Adamantidis, A., Celio, M. R.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 19-11-2019
Nature Publishing Group
Nature Portfolio
Subjects:
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Ablation
Animals
Brain stem
Calbindin-D28K
Electroencephalography
Electromyography
Electrooculography
Eye movements
Eye Movements - physiology
Humanities and Social Sciences
Humans
Macaca fascicularis
Macaca mulatta
Medulla Oblongata - cytology
Medulla Oblongata - physiology
Mice, Inbred C57BL
Mice, Transgenic
Motor Neurons - physiology
multidisciplinary
Muscles
Neurons
Neurons - physiology
Optogenetics
REM sleep
Science
Science (multidisciplinary)
Sleep
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Summary:Rapid eye movements (REM) are characteristic of the eponymous phase of sleep, yet the underlying motor commands remain an enigma. Here, we identified a cluster of Calbindin-D28K-expressing neurons in the Nucleus papilio (NP Calb ), located in the dorsal paragigantocellular nucleus, which are active during REM sleep and project to the three contralateral eye-muscle nuclei. The firing of opto-tagged NP Calb neurons is augmented prior to the onset of eye movements during REM sleep. Optogenetic activation of NP Calb neurons triggers eye movements selectively during REM sleep, while their genetic ablation or optogenetic silencing suppresses them. None of these perturbations led to a change in the duration of REM sleep episodes. Our study provides the first evidence for a brainstem premotor command contributing to the control of eye movements selectively during REM sleep in the mammalian brain. Rapid eye movement (REM) sleep is a sleep phase characterised by random eye movements for which the underlying motor commands are yet to be revealed. The authors describe that a cluster of medulla oblongata neurons in the Nucleus papilio contributes to the control of eye movements during REM sleep.
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SourceType-Scholarly Journals-1
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-019-13217-y