Antiaggregation action of chloroquine

The authors have studied in vitro the platelet aggregability induced with ADP, collagen and ristocetin. Chloroquine was added at increasing concentration (3,2 mgr/l, 16 mgr/l, 32 mgr/l). The results have been highly significant. They showed that chloroquine has an anti aggregating effect with the th...

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Bibliographic Details
Published in:	Médecine tropicale Vol. 50; no. 1; p. 143
Main Authors:	Bertrand, E, Cloitre, B, Ticolat, R, Bile, R K, Gautier, C, Abiyou, G O, Bohui, B Y
Format:	Magazine Article
Language:	French
Published:	France 01-01-1990
Subjects:	Adult Blood Platelets - analysis Blood Platelets - drug effects Blood Platelets - physiology Chloroquine - administration & dosage Chloroquine - pharmacology Female Humans Male Phospholipases - analysis Platelet Aggregation - drug effects Platelet Aggregation Inhibitors
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Summary:	The authors have studied in vitro the platelet aggregability induced with ADP, collagen and ristocetin. Chloroquine was added at increasing concentration (3,2 mgr/l, 16 mgr/l, 32 mgr/l). The results have been highly significant. They showed that chloroquine has an anti aggregating effect with the three inducing agents. This effect was increasing with the chloroquine concentration. Some previous works have been indicative of the inhibiting effect of chloroquine on platelet aggregability. In the treatment of the malaria, this inhibiting effect could be complementary with the specific antiparasitic effect. On the other hand the inhibiting effect on platelet aggregability could be useful for the prevention of thrombosis.
ISSN:	0025-682X