Search Results - "Bilder, Donna M"

Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection by Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona

“…The discovery of BMS-605339 (35), a tripeptidic inhibitor of the NS3/4A enzyme, is described. This compound incorporates a cyclopropyl­acylsulfonamide moiety…”
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The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection by Scola, Paul M., Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Jie, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley V., Zheng, Barbara, Hewawasam, Piyasena, Tu, Yong, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Levine, Steven, Chen, Chaoqun, Yu, Fei, Sheaffer, Amy K., Zhai, Guangzhi, Barry, Diana, Knipe, Jay O., Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W., Zvyaga, Tatyana, Good, Andrew C., Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E., Gao, Qi, Mueller, Luciano, Colonno, Richard J., Grasela, Dennis M., Adams, Stephen P., Loy, James, Levesque, Paul C., Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona

“…The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is currently in phase III clinical…”
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Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ by Myers, Michael C., Bilder, Donna M., Cavallaro, Cullen L., Chao, Hannguang J., Su, Shun, Burford, Neil T., Nayeem, Akbar, Wang, Tao, Yan, Mujing, Langish, Robert A., Dabros, Marta, Li, Yi-Xin, Rose, Anne V., Behnia, Kamelia, Onorato, Joelle M., Gargalovic, Peter S., Wexler, Ruth R., Lawrence, R. Michael

“…[Display omitted] This article describes the discovery of aryl hydroxy pyrimidinones and the medicinal chemistry efforts to optimize this chemotype for potent…”
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Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing by Sun, Li-Qiang, Mull, Eric, Zheng, Barbara, D’Andrea, Stanley, Zhao, Qian, Wang, Alan Xiangdong, Sin, Ny, Venables, Brian L, Sit, Sing-Yuen, Chen, Yan, Chen, Jie, Cocuzza, Anthony, Bilder, Donna M, Mathur, Arvind, Rampulla, Richard, Chen, Bang-Chi, Palani, Theerthagiri, Ganesan, Sivakumar, Arunachalam, Pirama Nayagam, Falk, Paul, Levine, Steven, Chen, Chaoqun, Friborg, Jacques, Yu, Fei, Hernandez, Dennis, Sheaffer, Amy K, Knipe, Jay O, Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W, Zvyaga, Tatyana, Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E, Gao, Qi, Ng, Alicia, Mueller, Luciano, Grasela, Dennis M, Adams, Stephen, Loy, James, Levesque, Paul C, Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Wang, Ying-Kai, Fang, Hua, Cockett, Mark I, Meanwell, Nicholas A, McPhee, Fiona, Scola, Paul M

“…The discovery of a back-up to the hepatitis C virus NS3 protease inhibitor asunaprevir (2) is described. The objective of this work was the identification of a…”
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The preparation of aryl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfides and sulfones by Egolf, Roger A., Bilder, Donna M.

“…A series of aryl 1‐(2,6‐dimethylphenyl)‐2‐phenyl‐4‐trifluoromethyl‐5‐imidazolyl sulfides was prepared by displacement of fluoride from the 5‐position of…”
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