Search Results - "Bilder, David"

Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting by Figueroa-Clarevega, Alejandra, Bilder, David

“…Tumors kill patients not only through well-characterized perturbations to their local environment but also through poorly understood pathophysiological…”
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Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors by Bilder, David

“…Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether polarity loss might causally contribute to cancer has remained…”
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Global Tissue Revolutions in a Morphogenetic Movement Controlling Elongation by Haigo, Saori L, Bilder, David

“…Polarized cell behaviors drive axis elongation in animal embryos, but the mechanisms underlying elongation of many tissues remain unknown. Eggs of Drosophila…”
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Distinct activities of Scrib module proteins organize epithelial polarity by Khoury, Mark J., Bilder, David

“…A polarized architecture is central to both epithelial structure and function. In many cells, polarity involves mutual antagonism between the Par complex and…”
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Taking Stock of the Drosophila Research Ecosystem by Bilder, David, Irvine, Kenneth D

“…With a century-old history of fundamental discoveries, the fruit fly has long been a favored experimental organism for a wide range of scientific inquiries…”
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Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation by Chen, Dong-Yuan, Crest, Justin, Streichan, Sebastian J., Bilder, David

“…Organs are sculpted by extracellular as well as cell-intrinsic forces, but how collective cell dynamics are orchestrated in response to environmental cues is…”
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Endocytic control of epithelial polarity and proliferation in Drosophila by Bilder, David, Lu, Han

“…Intracellular protein transport is a key factor in epithelial cell polarity. Here we report that mutations in two core components of the vesicle trafficking…”
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The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor by Vaccari, Thomas, Duchi, Serena, Cortese, Katia, Tacchetti, Carlo, Bilder, David

“…Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the mechanisms involved are not clear. In a search for factors that…”
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Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localization by Kim, Jung, Bilder, David, Neufeld, Thomas P

“…Insulin resistance, the failure to activate insulin signaling in the presence of ligand, leads to metabolic diseases, including type 2 diabetes. Physical…”
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Tumor-induced disruption of the blood-brain barrier promotes host death by Kim, Jung, Chuang, Hsiu-Chun, Wolf, Natalie K., Nicolai, Christopher J., Raulet, David H., Saijo, Kaoru, Bilder, David

“…Cancer patients often die from symptoms that manifest at a distance from any tumor. Mechanisms underlying these systemic physiological perturbations, called…”
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Expanding the Morphogenetic Repertoire: Perspectives from the Drosophila Egg by Bilder, David, Haigo, Saori L.

“…Tissue and organ architectures are incredibly diverse, yet our knowledge of the morphogenetic behaviors that generate them is relatively limited. Recent…”
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Endocytic Internalization Routes Required for Delta/Notch Signaling by Windler, Sarah L., Bilder, David

“…The internalization of transmembrane receptors from the cell surface plays a central role in signal regulation. Receptor internalization can occur through…”
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Organ sculpting by patterned extracellular matrix stiffness by Crest, Justin, Diz-Muñoz, Alba, Chen, Dong-Yuan, Fletcher, Daniel A, Bilder, David

“…How organ-shaping mechanical imbalances are generated is a central question of morphogenesis, with existing paradigms focusing on asymmetric force generation…”
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A Cell Migration Tracking Tool Supports Coupling of Tissue Rotation to Elongation by Chen, Dong-Yuan, Crest, Justin, Bilder, David

“…Cell migration is indispensable to morphogenesis and homeostasis. Live imaging allows mechanistic insights, but long-term observation can alter normal biology,…”
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Endosomal entry regulates Notch receptor activation in Drosophila melanogaster by Vaccari, Thomas, Lu, Han, Kanwar, Ritu, Fortini, Mark E, Bilder, David

“…Signaling through the transmembrane receptor Notch is widely used throughout animal development and is a major regulator of cell proliferation and…”
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The transcriptional response to tumorigenic polarity loss in Drosophila by Bunker, Brandon D, Nellimoottil, Tittu T, Boileau, Ryan M, Classen, Anne K, Bilder, David

“…Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganization drives oncogenic transcriptional events remains…”
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Minimal functional domains of the core polarity regulator Dlg by Khoury, Mark J., Bilder, David

“…ABSTRACT The compartmentalized domains of polarized epithelial cells arise from mutually antagonistic actions between the apical Par complex and the…”
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Integrated activity of PDZ protein complexes regulates epithelial polarity by Bilder, David, Schober, Markus, Perrimon, Norbert

“…Polarized cells contain numerous membrane domains, but it is unclear how the formation of these domains is coordinated to create a single integrated cell…”
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Localization of apical epithelial determinants by the basolateral PDZ protein Scribble by Bilder, David, Perrimon, Norbert

“…The generation of membrane domains with distinct protein constituents is a hallmark of cell polarization. In epithelia, segregation of membrane proteins into…”
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Mass transit: Epithelial morphogenesis in the Drosophila egg chamber by Horne‐Badovinac, Sally, Bilder, David

“…Epithelial cells use a striking array of morphogenetic behaviors to sculpt organs and body plans during development. Although it is clear that epithelial…”
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