Search Results - "Bilci, Natalie A"

Isoindolines: A new series of potent and selective endothelin-A receptor antagonists by Kukkola, Paivi J., Bilci, Natalie A., Ikler, Theodore, Savage, Paula, Shetty, Suraj S., DelGrande, Dominick, Jeng, Arco Y.

“…1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of…”
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Perhydroquinolylbenzamides as Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 by Coppola, Gary M, Kukkola, Paivi J, Stanton, James L, Neubert, Alan D, Marcopulos, Nicholas, Bilci, Natalie A, Wang, Hua, Tomaselli, Hollis C, Tan, Jenny, Aicher, Thomas D, Knorr, Douglas C, Jeng, Arco Y, Dardik, Beatriz, Chatelain, Ricardo E

“…High-throughput screening identified 5 as a weak inhibitor of 11β-HSD1. Optimization of the structure led to a series of perhydroquinolylbenzamides, some with…”
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Differential structure-activity relationships of phosphoramidon analogues for inhibition of three metalloproteases: endothelin-converting enzyme, neutral endopeptidase, and angiotensin-converting enzyme by Kukkola, P J, Savage, P, Sakane, Y, Berry, J C, Bilci, N A, Ghai, R D, Jeng, A Y

“…The structure-activity relationships of phosphoramidon analogues for inhibition of endothelin-converting enzyme (ECE), neutral endopeptidase 24.11 (NEP), and…”
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Perhydroquinolylbenzamides as novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by Coppola, Gary M, Kukkola, Paivi J, Stanton, James L, Neubert, Alan D, Marcopulos, Nicholas, Bilci, Natalie A, Wang, Hua, Tomaselli, Hollis C, Tan, Jenny, Aicher, Thomas D, Knorr, Douglas C, Jeng, Arco Y, Dardik, Beatriz, Chatelain, Ricardo E

“…High-throughput screening identified 5 as a weak inhibitor of 11beta-HSD1. Optimization of the structure led to a series of perhydroquinolylbenzamides, some…”
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A novel regio- and stereoselective synthesis of isoindolines by Kukkola, Paivi J., Bilci, Natalie A., Ikeler, Theodore J.

“…The described synthesis of isomeric isoindoline dicarboxylic acid analogs 1 and 2, two potent ET A selective receptor antagonists, involves an efficient…”
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Optimization of retro-thiorphan for inhibition of endothelin converting enzyme by Kukkola, Paivi J., Bilci, Natalie A., Kozak, W.X., Savage, Paula, Jeng, Arco Y.

“…The structural requirements of retro-thiorphan, N-[1 R, S-benzyl-2-mercaptoethyl]malonamic acid 2, analogs for the inhibition of endothelin converting enzyme…”
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