Search Results - "Bikoff, Elizabeth K."

Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy by Nelson, Andrew C., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…Growth and survival of the mammalian embryo within the uterine environment depends on the placenta, a highly complex vascularized organ comprised of both…”
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Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse by Senft, Anna D., Bikoff, Elizabeth K., Robertson, Elizabeth J., Costello, Ita

“…The essential roles played by Nodal and Bmp signalling during early mouse development have been extensively documented. Here we use conditional deletion…”
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transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes by Harper, James, Mould, Arne, Andrews, Robert M, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Female mammals produce milk to feed their newborn offspring before teeth develop and permit the consumption of solid food. Intestinal enterocytes dramatically…”
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Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life by Elias, Salah, Morgan, Marc A., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly…”
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Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse by Arnold, Sebastian J, Hofmann, Ulf K, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…The T-box transcription factor eomesodermin ( Eomes ) has been implicated as an important component in germ layer induction and patterning in vertebrate…”
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The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice by Goolam, Mubeen, Xypolita, Maria-Eleni, Costello, Ita, Lydon, John P., DeMayo, Francesco J., Bikoff, Elizabeth K., Robertson, Elizabeth J., Mould, Arne W.

“…The transcriptional repressor Blimp1 controls cell fate decisions in the developing embryo and adult tissues. Here we describe Blimp1 expression and functional…”
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Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta by Mould, Arne, Morgan, Marc A J, Li, Li, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Developmental arrest of Blimp1/Prdm1 mutant embryos at around embryonic day 10.5 (E10.5) has been attributed to placental disturbances. Here we investigate…”
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Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation by Mould, Arne W, Morgan, Marc A J, Nelson, Andrew C, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…The neonatal intestine is a very complex and dynamic organ that must rapidly adapt and remodel in response to a barrage of environmental stimuli during the…”
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Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation by Nelson, Andrew C., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…Trophoblast stem cells (TSCs) give rise to specialized cell types within the placenta. However, the regulatory mechanisms that guide trophoblast cell fate…”
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The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse by Vincent, Stéphane D, Dunn, N Ray, Sciammas, Roger, Shapiro-Shalef, Miriam, Davis, Mark M, Calame, Kathryn, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Blimp1, a zinc-finger containing DNA-binding transcriptional repressor, functions as a master regulator of B cell terminal differentiation. Considerable…”
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Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice by Robertson, Elizabeth J, Charatsi, Iphigenie, Joyner, Clive J, Koonce, Chad H, Morgan, Marc, Islam, Ayesha, Paterson, Carol, Lejsek, Emily, Arnold, Sebastian J, Kallies, Axel, Nutt, Stephen L, Bikoff, Elizabeth K

“…The zinc-finger transcriptional repressor Blimp1 (Prdm1) controls gene expression patterns during differentiation of B lymphocytes and regulates epigenetic…”
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The PR/SET Domain Zinc Finger Protein Prdm4 Regulates Gene Expression in Embryonic Stem Cells but Plays a Nonessential Role in the Developing Mouse Embryo by Bogani, Debora, Morgan, Marc A. J., Nelson, Andrew C., Costello, Ita, McGouran, Joanna F., Kessler, Benedikt M., Robertson, Elizabeth J., Bikoff, Elizabeth K.

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Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes by Paley, Michael A., Gordon, Scott M., Bikoff, Elizabeth K., Robertson, Elizabeth J., Wherry, E. John, Reiner, Steven L.

“…Fluorescent reporter allele provides insights on the role for eomesodermin in NK development, CD8+ T cell effector function, and central memory formation. The…”
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Blimp-1/Prdm1 Alternative Promoter Usage during Mouse Development and Plasma Cell Differentiation by Morgan, Marc A. J., Magnusdottir, Erna, Kuo, Tracy C., Tunyaplin, Chai, Harper, James, Arnold, Sebastian J., Calame, Kathryn, Robertson, Elizabeth J., Bikoff, Elizabeth K.

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The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo by Norris, Dominic P, Brennan, Jane, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…The TGFβ-related growth factor Nodal governs anteroposterior (AP) and left-right (LR) axis formation in the vertebrate embryo. A conserved intronic enhancer…”
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Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo by Dunn, N Ray, Vincent, Stéphane D, Oxburgh, Leif, Robertson, Elizabeth J, Bikoff, Elizabeth K

“…TGFβ/activin/Nodal receptors activate both Smad2 and Smad3 intracellular effector proteins. The functional activities of these closely related molecules have…”
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Alternative Splicing Regulates Prdm1/Blimp-1 DNA Binding Activities and Corepressor Interactions by Morgan, Marc A. J., Mould, Arne W., Li, Li, Robertson, Elizabeth J., Bikoff, Elizabeth K.

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The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice by Morgan, Marc A J, Muller, Pari S S, Mould, Arne, Newland, Stephen A, Nichols, Jennifer, Robertson, Elizabeth J, Cooke, Anne, Bikoff, Elizabeth K

“…The spontaneous destruction of insulin producing pancreatic beta cells in non-obese diabetic (NOD) mice provides a valuable model of type 1 diabetes. As in…”
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Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development by Costello, Ita, Biondi, Christine A, Taylor, Jennifer M, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Smad4 mutant embryos arrest shortly after implantation and display a characteristic shortened proximodistal axis, a significantly reduced epiblast, as well as…”
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Progenitor and Terminal Subsets of CD8⁺ T Cells Cooperate to Contain Chronic Viral Infection by Paley, Michael A., Kroy, Daniela C., Odorizzi, Pamela M., Johnnidis, Jonathan B., Dolfi, Douglas V., Barnett, Burton E., Bikoff, Elizabeth K., Robertson, Elizabeth J., Lauer, Georg M., Reiner, Steven L., Wherry, E. John

“…Chronic infections strain the regenerative capacity of antiviral T lymphocyte populations, leading to failure in long-term immunity. The cellular and molecular…”
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