Search Results - "Bikhazi, Anwar B."
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Comparative pharmacokinetics and metabolic pathway of gemcitabine during intravenous and intra-arterial delivery in unresectable pancreatic cancer patients
Published in Clinical pharmacokinetics (01-01-2005)“…To study the pharmacokinetics and clinical outcome of gemcitabine (2'-2'-difluoro-deoxcytidine [dFdC]) during intra-arterial versus intravenous delivery in…”
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Effects of Selenium and Exendin-4 on Glucagon-Like Peptide-1 Receptor, IRS-1, and Raf-1 in the Liver of Diabetic Rats
Published in Biochemical genetics (01-12-2012)“…Selenium and exendin-4 exert antidiabetic effects by unknown mechanisms. Herein, we investigated their effects on the expression of glucagon-like peptide-1…”
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Aliskiren, exendin-4, and insulin: their impact on endothelin receptor subtype(s) regulation/binding in type 1 diabetic rat hearts
Published in Canadian journal of physiology and pharmacology (01-10-2013)“…This study focuses on the impact of aliskiren and (or) glucagon-like peptide-1 analogue on the binding affinity/regulation of endothelin-1 (ET-1) to its…”
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Kinetics of lipopolysaccharide clearance by Kupffer and parenchyma cells in perfused rat liver
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-08-2001)“…We studied the kinetics of [ 3H]lipopolysaccharide ([ 3H]LPS) (endotoxin) binding to Kupffer cells and hepatocytes at the level of the microtubular system…”
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Role of insulin on jejunal PepT1 expression and function regulation in diabetic male and female rats
Published in Canadian journal of physiology and pharmacology (01-07-2010)“…The aim of this study was to determine whether the jejunal oligopeptide transporter PepT1 is regulated by insulin and whether this regulation is sex-dependent…”
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Role of glucagon-like peptide-1 and its agonists on early prevention of cardiac remodeling in type 1 diabetic rat hearts
Published in General physiology and biophysics (01-03-2011)“…Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from intestinal L cells upon nutrients ingestion, and is currently used for treating diabetes…”
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Role of glucagon-like peptide-1 analogues on insulin receptor regulation in diabetic rat hearts
Published in Canadian journal of physiology and pharmacology (01-01-2010)“…This study focused on the regulation and affinity modulation of the insulin receptor of coronary endothelium and cardiomyocytes in nondiabetic and STZ-induced…”
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Effect of Diabetes Mellitus and Insulin on the Regulation of the PepT 1 Symporter in Rat Jejunum
Published in Molecular pharmaceutics (01-07-2004)“…This investigation focused on studying the effects of insulin-dependent diabetes mellitus and insulin treatment on absorption of glycylsarcosine (Gly-Sar)…”
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Effect of type-1 diabetes mellitus on the regulation of insulin and endothelin-1 receptors in rat hearts
Published in Canadian journal of physiology and pharmacology (01-02-2007)“…This project assesses the treatment role with insulin and (or) angiotensin II receptor subtype-1 (AT1-R) blocker (ARB) on insulin receptor and endothelin-1…”
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Effect of insulin and angiotensin II receptor subtype-1 antagonist on myocardial remodelling in rats with insulin-dependent diabetes mellitus
Published in Journal of hypertension (01-02-2005)“…To assess the role of insulin or an angiotensin II receptor antagonist (losartan), or both, in preventing cardiomyocyte damage in rats suffering from…”
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Cross-talk related to insulin and angiotensin II binding on myocardial remodelling in diabetic rat hearts
Published in Journal of the renin-angiotensin-aldosterone system (01-06-2007)“…This study focused on the regulation and affinity modulation of angiotensin II (Ang II) binding to its receptor subtypes (AT1- and AT2-receptor) in the…”
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Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (2003)“…Endothelin-1 (ET-1) pathophysiologic actions are mediated via binding with two receptor subtypes, ET A and ET B. Release of ET-1 from endocardial endothelial…”
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Endothelium and myocyte cellular insulin receptor alterations in a rat model of myocardial infarction
Published in Canadian journal of physiology and pharmacology (01-03-2003)“…Ischemic heart disease is considered to be one of the leading causes of death in adults. While extensive research on mechanisms contributing to the…”
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Characterization of insulin-resistance: role of receptor alteration in insulin-dependent diabetes mellitus, essential hypertension and cardiac hypertrophy
Published in European journal of pharmaceutical sciences (01-10-2000)“…Insulin-resistance is associated with a number of disease states such as diabetes, syndrome X, and hypertension. These situations may be coupled to…”
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Effect of systemic insulin and angiotensin II receptor subtype-1 antagonist on endothelin-1 receptor subtype(s) regulation and binding in diabetic rat heart
Published in Endothelium (New York, N.Y.) (01-09-2005)“…This study reports on the regulation and remodeling role of endothelin-1 (ET-1) and its receptor subtypes, ET(A)-Rs/ET(B)-Rs, at the coronary endothelium (CE)…”
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Angiotensin II binding and extracellular matrix remodelling in a rat model of myocardial infarction
Published in Journal of the renin-angiotensin-aldosterone system (01-12-2000)“…Clinical evidence points to a role for angiotensin II (Ang II) in the post-infarction remodelling of cardiac hypertrophy. The present study was designed to…”
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Two uncompetitive, activated, and transport sites of the Na +/H + exchanger for pH regulation in perfused rat kidney
Published in Comparative biochemistry and physiology. Part A, Molecular & integrative physiology (01-08-1999)“…The purpose of this study is to assess the effect of an apparent alteration in intracellular pH and the effect of amiloride on the activity of the Na +/H +…”
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Effect of Omega‐3 PUFA on Endothelin‐1 Receptors in Normal and Type 1 Diabetic Rat Hearts
Published in The FASEB journal (01-04-2012)“…Abstract only Cardiovascular disease is a major complication in diabetes. Its management includes renin‐angiotensin‐system components, endothelial factors…”
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Assessment of Glucagon-Like Peptide-1 Analogue and Renin Inhibitor on the Binding and Regulation of GLP-1 Receptor in Type 1 Diabetic Rat Hearts
Published in Experimental diabetes research (01-01-2011)“…This study focuses on the effects of long-term renin-angiotensin system suppression and/or incretin mimetic therapies on the regulation and binding affinity of…”
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Binding and distribution of three prototype calcium channel blockers in perfused rat liver
Published in Molecular and cellular biochemistry (01-04-1997)“…This work represents a study of the binding and distribution of three different calcium channel blockers in the Sprague-Dawley rat liver, using an in situ…”
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