Search Results - "Bijnsdorp, Irene V."

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes by Koppers-Lalic, Danijela, Hackenberg, Michael, Bijnsdorp, Irene V., van Eijndhoven, Monique A.J., Sadek, Payman, Sie, Daud, Zini, Nicoletta, Middeldorp, Jaap M., Ylstra, Bauke, de Menezes, Renee X., Würdinger, Thomas, Meijer, Gerrit A., Pegtel, D. Michiel

“…Functional biomolecules, including small noncoding RNAs (ncRNAs), are released and transmitted between mammalian cells via extracellular vesicles (EVs),…”
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Urinary exosomal proteins as (pan‐)cancer biomarkers: insights from the proteome by Erozenci, Leyla Ayse, Böttger, Franziska, Bijnsdorp, Irene V., Jimenez, Connie R.

“…Exosomes are extracellular vesicles (EVs) released from cells under both physiological and pathological conditions, and may, thus, be present in biofluids…”
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Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles by Erdbrügger, Uta, Blijdorp, Charles J., Bijnsdorp, Irene V., Borràs, Francesc E., Burger, Dylan, Bussolati, Benedetta, Byrd, James Brian, Clayton, Aled, Dear, James W., Falcón‐Pérez, Juan M., Grange, Cristina, Hill, Andrew F., Holthöfer, Harry, Hoorn, Ewout J., Jenster, Guido, Jimenez, Connie R., Junker, Kerstin, Klein, John, Knepper, Mark A., Koritzinsky, Erik H., Luther, James M., Lenassi, Metka, Leivo, Janne, Mertens, Inge, Musante, Luca, Oeyen, Eline, Puhka, Maija, Royen, Martin E., Sánchez, Catherine, Soekmadji, Carolina, Thongboonkerd, Visith, Steijn, Volkert, Verhaegh, Gerald, Webber, Jason P., Witwer, Kenneth, Yuen, Peter S.T., Zheng, Lei, Llorente, Alicia, Martens‐Uzunova, Elena S.

“…Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast‐growing…”
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Longitudinal stability of urinary extracellular vesicle protein patterns within and between individuals by Erozenci, Leyla A., Piersma, Sander R., Pham, Thang V., Bijnsdorp, Irene V., Jimenez, Connie R.

“…The protein content of urinary extracellular vesicles (EVs) is considered to be an attractive non-invasive biomarker source. However, little is known about the…”
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Protein homeostasis maintained by HOOK1 levels promotes the tumorigenic and stemness properties of ovarian cancer cells through reticulum stress and autophagy by Suárez-Martínez, Elisa, Piersma, Sander R, Pham, Thang V, Bijnsdorp, Irene V, Jimenez, Connie R, Carnero, Amancio

“…Ovarian cancer has a high mortality rate mainly due to its resistance to currently used therapies. This resistance has been associated with the presence of…”
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Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5‐fluorouracil in colon cancer cells by Bijnsdorp, Irene V., Peters, Godefridus J., Temmink, Olaf H., Fukushima, Masakazu, Kruyt, Frank A.

“…Trifluorothymidine (TFT) is part of the oral drug formulation TAS‐102. Both 5‐fluorouracil (5‐FU) and TFT can inhibit thymidylate synthase and be incorporated…”
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Protein kinase D drives the secretion of invasion mediators in triple-negative breast cancer cell lines by Gali, Alexia, Bijnsdorp, Irene V., Piersma, Sander R., Pham, Thang V., Gutiérrez-Galindo, Elena, Kühnel, Fiona, Tsolakos, Nikos, Jimenez, Connie R., Hausser, Angelika, Alexopoulos, Leonidas G.

“…The protein kinase D (PKD) family members regulate the fission of cargo vesicles at the Golgi complex and play a pro-oncogenic role in triple-negative breast…”
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Integration of stool microbiota, proteome and amino acid profiles to discriminate patients with adenomas and colorectal cancer by Bosch, Sofie, Acharjee, Animesh, Quraishi, Mohammed Nabil, Bijnsdorp, Irene V, Rojas, Patricia, Bakkali, Abdellatif, Jansen, Erwin EW, Stokkers, Pieter, Kuijvenhoven, Johan, Pham, Thang V, Beggs, Andrew D, Jimenez, Connie R, Struys, Eduard A, Gkoutos, Georgios V, de Meij, Tim GJ, de Boer, Nanne KH

“…Screening for colorectal cancer (CRC) reduces its mortality but has limited sensitivity and specificity. Aims We aimed to explore potential biomarker panels…”
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Feasibility of urinary extracellular vesicle proteome profiling using a robust and simple, clinically applicable isolation method by Bijnsdorp, Irene V., Maxouri, Olga, Kardar, Aarzo, Schelfhorst, Tim, Piersma, Sander R., Pham, Thang V., Vis, Andre, van Moorselaar, R. Jeroen, Jimenez, Connie R.

“…Extracellular vesicles (EVs) secreted by prostate cancer (PCa) cells contain specific biomarkers and can be isolated from urine. Collection of urine is not…”
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Large-Scale Urinary Proteome Dataset Across Tumor Types Reveals Candidate Biomarkers for Lung Cancer by Bijnsdorp, Irene V., Jimenez, Connie R.

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The Non-Coding Transcriptome of Prostate Cancer: Implications for Clinical Practice by Bijnsdorp, Irene V., van Royen, Martin E., Verhaegh, Gerald W., Martens-Uzunova, Elena S.

“…Prostate cancer (PCa) is the most common type of cancer and the second leading cause of cancer-related death in men. Despite extensive research, the molecular…”
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Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients by Bijnsdorp, Irene V., Geldof, Albert A., Lavaei, Mehrdad, Piersma, Sander R., van Moorselaar, R. Jeroen A., Jimenez, Connie R.

“…Cancer cells are able to change the protein expression and behavior of non-cancerous surrounding cells. Exosomes, secreted by prostate cancer (PCa) cells, may…”
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Protein Complexes in Urine Interfere with Extracellular Vesicle Biomarker Studies by Wachalska, Magda, Koppers-Lalic, Danijela, van Eijndhoven, Monique, Pegtel, Michiel, Geldof, Albert A., Lipinska, Andrea D., van Moorselaar, R. Jeroen, Bijnsdorp, Irene V.

“…Urine exosomes (extracellular vesicles; EVs) contain (micro)RNA (miRNA) and protein biomarkers that are useful for the non-invasive diagnosis of various…”
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Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines by Bijnsdorp, Irene V., Kruyt, Frank A. E., Fukushima, Masakazu, Smid, Kees, Gokoel, Shanti, Peters, Godefridus J.

“…The pyrimidine trifluorothymidine (TFT) inhibits thymidylate synthase (TS) and can be incorporated into the DNA. TFT, as part of TAS‐102, is clinically…”
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The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells by Azijli, Kaamar, van Roosmalen, Ingrid A. M., Smit, Jorn, Pillai, Saravanan, Fukushima, Masakazu, de Jong, Steven, Peters, Godefridus J., Bijnsdorp, Irene V., Kruyt, Frank A. E.

“…Purpose TRAIL, a tumor selective anticancer agent, may be used for the treatment of non-small cell lung cancer (NSCLC). However, TRAIL resistance is frequently…”
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Secretome processing for proteomics: A methods comparison by Almeida‐Marques, Catarina, Rolfs, Frank, Piersma, Sander R., Bijnsdorp, Irene V., Pham, Thang V., Knol, Jaco C., Jimenez, Connie R.

“…The cancer cell secretome comprises a treasure‐trove for biomarkers since it reflects cross‐talk between tumor cells and their surrounding environment with…”
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Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension by Manz, Xue D, Szulcek, Robert, Pan, Xiaoke, Symersky, Petr, Dickhoff, Chris, Majolée, Jisca, Kremer, Veerle, Michielon, Elisabetta, Jordanova, Ekaterina S, Radonic, Teodora, Bijnsdorp, Irene V, Piersma, Sander R, Pham, Thang V, Jimenez, Connie R, Vonk Noordegraaf, Anton, de Man, Frances S, Boon, Reinier A, Voorberg, Jan, Hordijk, Peter L, Aman, Jurjan, Bogaard, Harm Jan

“…von Willebrand factor (vWF) mediates platelet adhesion during thrombosis. While chronic thromboembolic pulmonary hypertension (CTEPH) is associated with…”
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Analysis of drug interactions by Bijnsdorp, Irene V, Giovannetti, Elisa, Peters, Godefridus J

“…Most of the current therapies against cancer, and also those against immune diseases or viral infections, consist of empirically designed combination…”
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Serum testosterone plays an important role in the metastatic ability of castration resistant prostate cancer by van der Sluis, Tim M., Bijnsdorp, Irene V., Jacobs, John J. L., Meuleman, Eric J. H., Rozendaal, Lawrence, Geldof, Albert A., van Moorselaar, R. Jeroen A., Vis, André N.

“…Purpose Prostate cells are dependent on androgens for growth and proliferation. Androgen deprivation therapy is the recommended treatment for…”
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Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells by Bijnsdorp, Irene V, van den Berg, Jaap, Kuipers, Gitta K, Wedekind, Laurine E, Slotman, Ben J, van Rijn, Johannes, Lafleur, M Vincent M, Sminia, Peter

“…The COX-2 protein is frequently overexpressed in human malignant gliomas. This expression has been associated with their aggressive growth characteristics and…”
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