Search Results - "Bijen, Helena M."

Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia by van der Lee, Dyantha I, Reijmers, Rogier M, Honders, Maria W, Hagedoorn, Renate S, de Jong, Rob Cm, Kester, Michel Gd, van der Steen, Dirk M, de Ru, Arnoud H, Kweekel, Christiaan, Bijen, Helena M, Jedema, Inge, Veelken, Hendrik, van Veelen, Peter A, Heemskerk, Mirjam Hm, Falkenburg, J H Frederik, Griffioen, Marieke

“…The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive…”
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Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs by Bijen, Helena M., van der Steen, Dirk M., Hagedoorn, Renate S., Wouters, Anne K., Wooldridge, Linda, Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.

“…Adoptive transfer of T cells engineered with a cancer-specific T cell receptor (TCR) has demonstrated clinical benefit. However, the risk for off-target…”
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Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface by Bijen, Helena M., Hassan, Chopie, Kester, Michel G. D., Janssen, George M. C., Hombrink, Pleun, Ru, Arnoud H., Drijfhout, Jan Wouter, Meiring, Hugo D., Jong, Ad P., Falkenburg, J. H. Frederik, Jimenez, Connie R., Heemskerk, Mirjam H. M., Veelen, Peter A.

“…Allogeneic stem cell transplantation has emerged as immunotherapy in the treatment of a variety of hematological malignancies. Its efficacy depends on…”
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Mutated NPM1 As Target for Immunotherapy of Acute Myeloid Leukemia by Van Der Lee, Dyantha I., Bijen, Helena M., Hagedoorn, Renate S., Honders, Willy M., Kester, Michel G.D., van der Steen, Dirk M., de Ru, Arnoud H., Jedema, Inge, Veelken, Hendrik, Heemskerk, Mirjam H.M., van Veelen, Peter A., Falkenburg, J.H. Frederik, Griffioen, Marieke

“…In AML, nucleophosmin (NPM1) is the gene that is most frequently mutated. Mutated NPM1 (ΔNPM1) is a driver gene that is essential for malignant transformation…”
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