A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor

A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor

Breathalyzers estimate Blood Alcohol Content (BAC) from the concentration of ethanol in the breath. Breathalyzers are easy to use but are limited either by their high price and by environmental concerns, or by a short lifetime and the need for continuous recalibration. Here, we demonstrate a proof-o...

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Bibliographic Details
Published in:Scientific reports Vol. 6; no. 1; p. 27582
Main Authors: Bihar, Eloїse, Deng, Yingxin, Miyake, Takeo, Saadaoui, Mohamed, Malliaras, George G., Rolandi, Marco
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 13-06-2016
Nature Publishing Group
Subjects:
639/166/985
639/925/350
Alcohol
Breath tests
Dehydrogenases
Electrochemistry
Electrolytes
Enzymes
Ethanol
Humanities and Social Sciences
multidisciplinary
Polymers
Potassium
Science
Sensors
Transistors
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Summary:Breathalyzers estimate Blood Alcohol Content (BAC) from the concentration of ethanol in the breath. Breathalyzers are easy to use but are limited either by their high price and by environmental concerns, or by a short lifetime and the need for continuous recalibration. Here, we demonstrate a proof-of-concept disposable breathalyzer using an organic electrochemical transistor (OECT) modified with alcohol dehydrogenase (ADH) as the sensor. The OECT is made with the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and is printed on paper. ADH and its cofactor nicotinamide adenine dinucleotide (NAD + ) are immobilized onto the OECT with an electrolyte gel. When the OECT-breathalyzer is exposed to ethanol vapor, the enzymatic reaction of ADH and ethanol transforms NAD + into NADH, which causes a decrease in the OECT source drain current. In this fashion, the OECT-breathalyzer easily detects ethanol in the breath equivalent to BAC from 0.01% to 0.2%. The use of a printed OECT may contribute to the development of breathalyzers that are disposable, ecofriendly and integrated with wearable devices for real-time BAC monitoring.
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These authors contributed equally to this work.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep27582