Search Results - "Bignon, J"

Long term improved quality of life by a 2-week group physical and educational intervention shortly after breast cancer chemotherapy completion. Results of the ‘Programme of Accompanying women after breast Cancer treatment completion in Thermal resorts’ (PACThe) randomised clinical trial of 251 patients by Kwiatkowski, F, Mouret-Reynier, M.A, Duclos, M, Leger-Enreille, A, Bridon, F, Hahn, T, Van Praagh-Doreau, I, Travade, A, Gironde, M, Bézy, O, Lecadet, J, Vasson, M.P, Jouvency, S, Cardinaud, S, Roques, C.F, Bignon, Y.-J

“…Abstract Background Quality of life (QoL) after breast cancer is nowadays a major challenge. Complementary interventions are necessary because of frequent…”
Get full text

Multicentric neoadjuvant pilot Phase II study of cetuximab combined with docetaxel in operable triple negative breast cancer by Nabholtz, J.M., Chalabi, N., Radosevic‐Robin, N., Dauplat, M.M., Mouret‐Reynier, M.A., Van Praagh, I., Servent, V., Jacquin, JP, Benmammar, K.E., Kullab, S., Bahadoor, M.R.K., Kwiatkowski, F., Cayre, A., Abrial, C., Durando, X., Bignon, Y.J., Chollet, P., Penault‐Llorca, F.

“…Systemic therapy for triple negative breast cancer (TNBC) is mostly based upon chemotherapy. Epithelial Growth Factor Receptor (EGFR) is overexpressed in…”
Get full text

Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study by Fleischhauer, Katharina, MD, Shaw, Bronwen E, Dr, Gooley, Theodore, Prof, Malkki, Mari, PhD, Bardy, Peter, MD, Bignon, Jean-Denis, MD, Dubois, Valérie, BSc, Horowitz, Mary M, Prof, Madrigal, J Alejandro, Prof, Morishima, Yasuo, Prof, Oudshoorn, Machteld, PhD, Ringden, Olle, Prof, Spellman, Stephen, MBS, Velardi, Andrea, Prof, Zino, Elisabetta, BSc, Petersdorf, Effie W, Prof

“…Summary Background The risks after unrelated-donor haemopoietic-cell transplantation with matched HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 alleles between donor…”
Get full text

Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis by Férec, C, Raguénès, O, Salomon, R, Roche, C, Bernard, J P, Guillot, M, Quéré, I, Faure, C, Mercier, B, Audrézet, M P, Guillausseau, P J, Dupont, C, Munnich, A, Bignon, J D, Le Bodic, L

“…Hereditary pancreatitis (HP) is a rare inherited disorder, characterised by recurrent episodes of pancreatitis often beginning in early childhood. The mode of…”
Get full text

Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review) by Aunoble, B, Sanches, R, Didier, E, Bignon, Y J

“…Ovarian cancer remains the leading cause of death from gynecologic malignancy in Western countries. This cancer results from a succession of genetic…”
Get more information

Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin by Gherbovet, O, Sánchez-Murcia, Pedro A, García Alvarez, M C, Bignon, J, Thoret, S, Gago, F, Roussi, F

“…Some hybrids of vinca alkaloids and phomopsin A, linked by a glycine pattern, have been synthesized in one or two steps, by an insertion reaction and shown to…”
Get more information

Report of a family segregating mutations in both the APC and MSH2 genes: juvenile onset of colorectal cancer in a double heterozygote by Uhrhammer, N., Bignon, Y.-J.

“…Background and aims Mutations in DNA mismatch repair genes are associated with high risk of digestive malignancies [hereditary non-polyposis colorectal cancer…”
Get full text

In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases by Hesling, C., D'Incan, M., Mansard, S., Franck, F., Corbin‐Duval, A., Chèvenet, C., Déchelotte, P., Madelmont, J‐C., Veyre, A., Souteyrand, P., Bignon, Y‐J.

“…Summary There is a growing body of evidence to support the efficacy of topical imiquimod in the treatment of primary skin carcinomas. Conflicting data exist…”
Get full text

Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway by LAFARGE, Stéphane, SYLVAIN, Valérie, FERRARA, Marc, BIGNON, Yves-Jean

“…We have developed ribozymes (Rz) that inhibit BRCA1 expression in order to study the role of this gene in chemosensitivity. Two Rz, targeting positions 358 or…”
Get full text

Rare germline large rearrangements in the BRCA1/2 genes and eight candidate genes in 472 patients with breast cancer predisposition by Rouleau, E., Jesson, B., Briaux, A., Nogues, C., Chabaud, V., Demange, L., Sokolowska, J., Coulet, F., Barouk-Simonet, E., Bignon, Y. J., Bonnet, F., Bourdon, V., Bronner, M., Caputo, S., Castera, L., Delnatte, C., Delvincourt, C., Fournier, J., Hardouin, A., Muller, D., Peyrat, J. P., Toulas, C., Uhrhammer, N., Vidal, V., Stoppa-Lyonnet, D., Bieche, I., Lidereau, R.

“…Hereditary breast cancers account for up to 5–10 % of breast cancers and a majority are related to the BRCA1 and BRCA2 genes. However, many families with…”
Get full text

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis by Esteller, M, Fraga, M F, Guo, M, Garcia-Foncillas, J, Hedenfalk, I, Godwin, A K, Trojan, J, Vaurs-Barrière, C, Bignon, Y J, Ramus, S, Benitez, J, Caldes, T, Akiyama, Y, Yuasa, Y, Launonen, V, Canal, M J, Rodriguez, R, Capella, G, Peinado, M A, Borg, A, Aaltonen, L A, Ponder, B A, Baylin, S B, Herman, J G

“…Cancer cells have aberrant patterns of DNA methylation including hypermethylation of gene promoter CpG islands and global demethylation of the genome. Genes…”
Get full text

The regulatory role of the tetrapeptide AcSDKP in skin and hair physiology and the prevention of ageing effects in these tissues - a potential cosmetic role by Hajem, N., Chapelle, A., Bignon, J., Pinault, A., Liu, J.-M., Salah-Mohellibi, N., Lati, E., Wdzieczak-Bakala, J.

“…Synopsis The naturally occurring tetrapeptide acetyl‐N‐Ser‐Asp‐Lys‐Pro (AcSDKP) recognized as a potent angiogenic factor was shown recently to contribute to…”
Get full text

The effects of lycopene on the proliferation of human breast cells and BRCA1 and BRCA2 gene expression by Chalabi, N, Le Corre, L, Maurizis, J-C, Bignon, Y-J, Bernard-Gallon, D.J

“…The purpose of this study was to demonstrate the effects of lycopene, the major tomato carotenoid, on the expression of the BRCA1 and BRCA2 genes in three…”
Get full text

The Hereditary Pancreatitis Gene Maps to Long Arm of Chromosome 7 by Le Bodic, Louis, Bignon, Jean-Denis, Raguénès, Odile, Mercier, Bernard, Georgelin, Thierry, Schnee, Mathieu, Soulard, François, Gagne, Katia, Bonneville, Françoise, Muller, Jean-Yves, Bachner, Lucien, Férec, Claude

“…Hereditary pancreatitis (HP) is an autosomal dominant disorder with incomplete penetrance characterized by recurring episodes of severe abdominal pain often…”
Get full text

A Nonsense Mutation in the Hedgehog Receptor CDON Associated With Pituitary Stalk Interruption Syndrome by Bashamboo, A, Bignon-Topalovic, J, Rouba, H, McElreavey, K, Brauner, R

“…Background: Pituitary stalk interruption syndrome (PSIS) and holoprosencephaly (HPE) are congenital midline defects. Rare mutations in the sonic hedgehog (SHH)…”
Get full text

Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines by FUSTIER, P, LE CORRE, L, CHALABI, N, VISSAC-SABATIER, C, COMMUNAL, Y, BIGNON, Y-J, BERNARD-GALLON, D. J

“…The phytochemical resveratrol, found in grapes, berries and peanuts, has been found to possess cancer chemopreventive effects by inhibiting diverse cellular…”
Get full text

Comparison of dysplasia profiles in stimulated ovaries and in those with a genetic risk for ovarian cancer by Dauplat, J, Chene, G, Pomel, C, Dauplat, M.M, Bouëdec, G.Le, Mishellany, F, Lagarde, N, Bignon, Y.J, Jaffeux, P, Aublet-Cuvelier, B, Dechelotte, P, Pouly, J.L, Penault-Llorca, F

“…Abstract Aim Ovarian epithelial dysplasia (OED) was first described after prophylactic oophorectomy for genetic risk of ovarian cancer. In light of Fathalla’s…”
Get full text

Regulation of the Acetoin Catabolic Pathway Is Controlled by Sigma L in Bacillus subtilis by Ali, N O, Bignon, J, Rapoport, G, Debarbouille, M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Asbestos: Scientific Developments and Implications for Public Policy by Mossman, B. T., Bignon, J., Corn, M., Seaton, A., Gee, J. B. L.

“…Asbestos is a commercial term for a group of fibrous minerals often associated with the development of pulmonary interstitial fibrosis (asbestosis), lung…”
Get full text

Interaction between GSTM1-null and CYP2D6-deficient alleles in the pathogenesis of Parkinson's disease by Santt, O., Baranova, H., Albuisson, E., Bignon, Y.-J., Lucotte, G.

“…The present study was conducted to examine the interaction between cytochrome P450 2D6: CYP2D6 (phase I) poor metabolizer (PM) and glutathione S‐transferase…”
Get full text