Search Results - "Bigliardi, Paul L."

Synthetic Peptide Drugs for Targeting Skin Cancer: Malignant Melanoma and Melanotic Lesions by Eberle, Alex N, Rout, Bhimsen, Qi, Mei Bigliardi, Bigliardi, Paul L

“…Peptides play decisive roles in the skin, ranging from host defense responses to various forms of neuroendocrine regulation of cell and organelle function…”
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Investigating endogenous µ-opioid receptors in human keratinocytes as pharmacological targets using novel fluorescent ligand by Leong, Cheryl, Neumann, Christine, Ramasamy, Srinivas, Rout, Bhimsen, Yi Wee, Lim, Bigliardi-Qi, Mei, Bigliardi, Paul L

“…Opioids in skin function during stress response, regeneration, ageing and, particularly in regulating sensation. In chronic pruritus, topical treatment with…”
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Opioids and the skin - where do we stand? by Bigliardi, Paul L., Tobin, Desmond J., Gaveriaux-Ruff, Claire, Bigliardi-Qi, Mei

“…:  The common ectodermal origin of the skin and nervous systems can be expected to predict likely interactions in the adult. Over the last couple of decades…”
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Treatment of pruritus with topically applied opiate receptor antagonist by Bigliardi, Paul L., MD, Stammer, Holger, MSc, Jost, Gerhard, MD, Rufli, Theo, MD, Büchner, Stanislaw, MD, Bigliardi-Qi, Mei, PhD

“…Background Pruritus is the most common and distressing skin symptom, and treatment of itch is a problem for thousands of people. The currently available…”
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Honey flower dermatitis: Contact allergy to ellagic acid in Melianthuscomosus by Arora, Puneet, Magner, Evin T., Bigliardi, Paul L.

“…A case study is reported whereby a patient with no prior allergies developed a strong and spreading delayed-type hypersensitivity reaction to Melianthus…”
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The Diagnostic Value of Delayed-Type Reactions to Perennial Aeroallergens for Atopic Disease by Arora, Puneet, Freese, Rebecca L, Bigliardi, Paul L

“…Delayed-type reactions to aeroallergens have been observed, however, their clinical significance continues to be debated. We assessed the prevalence and…”
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Delayed-Type Reactions to Perennial Molds in an Atopic Patient by Arora, Puneet, Gaddis, Kevin J, Bigliardi, Paul L

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Opioids and skin homeostasis, regeneration and ageing - What's the evidence? by Bigliardi, Paul L., Dancik, Yuri, Neumann, Christine, Bigliardi-Qi, Mei

“…What has the opioid receptor system, known for beneficial as well as disastrous effects in the central nervous system, to do with skin? The question is…”
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Role of Skin pH in Psoriasis by Bigliardi, Paul L

“…Not much is known about the role of skin pH in skin pathophysiology, in particular in psoriasis. However, there is compelling evidence that the epidermal pH…”
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The δ-Opioid Receptor Affects Epidermal Homeostasis via ERK-Dependent Inhibition of Transcription Factor POU2F3 by Neumann, Christine, Bigliardi-Qi, Mei, Widmann, Christian, Bigliardi, Paul L.

“…Neuropeptides and their receptors are present in human skin, and their importance for cutaneous homeostasis and during wound healing is increasingly…”
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Delta opioid receptor expression correlates to skin ageing and melanin expression in Asian women by Bigliardi, Paul L., Lo, Sydney, Bigliardi, Elena, Dancik, Yuri, Leblanc‐Noblesse, Emmanuelle, Bigliardi‐Qi, Mei

“…While the evidence for the implication of opioid receptors (OPr) in ageing is growing, there is, to our knowledge, no study focusing directly on changes…”
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What happens in the skin? Integrating skin permeation kinetics into studies of developmental and reproductive toxicity following topical exposure by Dancik, Yuri, Bigliardi, Paul L., Bigliardi-Qi, Mei

“…•Animal-based studies investigating developmental and reproductive toxicology following skin exposure have not traditionally focused on the skin permeation…”
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Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia by Chew, Elaine G.Y., Tan, Joanna H.J., Bahta, Adiam W., Ho, Bryan S.-Y., Liu, Xingliang, Lim, Tze Chiun, Sia, Yee Yen, Bigliardi, Paul L., Heilmann, Stefanie, Wan, Andrew C.A., Nöthen, Markus M., Philpott, Michael P., Hillmer, Axel M.

“…Androgenetic alopecia (AGA) is a common heritable and androgen-dependent hair loss condition in men. Twelve genetic risk loci are known to date, but it is…”
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What You Need to Know About Hand Hygiene and Dermatitis During the Coronavirus Pandemic by Nguyen, Arthur S., Thielen, Brian V., Bigliardi, Paul L., Farah, Ronda S.

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The role of opioid receptors in migration and wound recovery in vitro in cultured human keratinocytes and fibroblasts by Bigliardi-Qi, Mei, Bigliardi, Paul L

“…We have previously described significant changes in skin differentiation and the delay in wound healing from delta-opioid receptor knockout mice. In addition,…”
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Structural and Functional Analysis of Intact Hair Follicles and Pilosebaceous Units by Volumetric Multispectral Optoacoustic Tomography by Ford, Steven J., Bigliardi, Paul L., Sardella, Thomas C.P., Urich, Alexander, Burton, Neal C., Kacprowicz, Marcin, Bigliardi, Mei, Olivo, Malini, Razansky, Daniel

“…Visualizing anatomical and functional features of hair follicle development in their unperturbed environment is key in understanding complex mechanisms of hair…”
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Physiological Doses of Red Light Induce IL‐4 Release in Cocultures between Human Keratinocytes and Immune Cells by Leong, Cheryl, Bigliardi, Paul L., Sriram, Gopu, Au, Veonice B., Connolly, John, Bigliardi‐Qi, Mei

“…Phototherapy is routinely used for the treatment of various skin conditions and targeted therapy of superficial cancers. However, the molecular mechanisms…”
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Peripheral nerve fibres form multifacet interactions with keratinocytes in a novel complete human 2D culture model by Krishnan‐Kutty, Viknish, Bigliardi, Paul L., Dykas, Michal Marcin, Pomp, Oz, Kyaw, Hpone Myint, Poddar, Kingshuk, Venkatesan, T., Bigliardi‐Qi, Mei

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Atopic Patients Who Fulfilled Rome III Criteria for Irritable Bowel Syndrome Had Higher Animal Danders Sensitization by Siah, Kewin T H, Santosa, Amelia, Cheung, Cynthia K Y, Soh, Alex Y S, Bigliardi, Paul L

“…The relationship between animal exposure and irritable bowel syndrome (IBS) is debated. Epidemiological studies have shown that atopy is more prevalent in IBS…”
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Deletion of μ- and κ-Opioid Receptors in Mice Changes Epidermal Hypertrophy, Density of Peripheral Nerve Endings, and Itch Behavior by Bigliardi-Qi, Mei, Gaveriaux-Ruff, Claire, Pfaltz, Katrin, Bady, Pierre, Baumann, Tommy, Rufli, Theo, Kieffer, Brigitte L., Bigliardi, Paul L.

“…The μ- (MOR) and κ- (KOR) opioid receptors have been implicated in the regulation of homeostasis of non-neuronal cells, such as keratinocytes, and sensations…”
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