Search Results - "Bigler, Raphael"

Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters by a 1,2-Metalate Rearrangement/1,3-Borotropic Shift Sequence by Aichhorn, Stefan, Bigler, Raphael, Myers, Eddie L, Aggarwal, Varinder K

“…Coupling reactions between benzylamines and boronic esters have been investigated. ortho-Lithiated benzylamines react with boronic esters and a N-activator to…”
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Isonitrile Iron(II) Complexes with Chiral N2P2 Macrocycles in the Enantioselective Transfer Hydrogenation of Ketones by Bigler, Raphael, Mezzetti, Antonio

“…Bis(isonitrile) iron(II) complexes bearing a C 2-symmetric N2P2 macrocyclic ligand, which are easily prepared from the corresponding bis(acetonitrile)…”
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Highly Enantioselective Transfer Hydrogenation of Ketones with Chiral (NH)2P2 Macrocyclic Iron(II) Complexes by Bigler, Raphael, Huber, Raffael, Mezzetti, Antonio

“…Bis(isonitrile) iron(II) complexes bearing a C2‐symmetric diamino (NH)2P2 macrocyclic ligand efficiently catalyze the hydrogenation of polar bonds of a broad…”
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Highly Enantioselective Transfer Hydrogenation of Polar Double Bonds by Macrocyclic Iron(II)/(NH)2P2 Catalysts by Bigler, Raphael, Mezzetti, Antonio

“…We describe herein a new protocol for the synthesis of 2,2′-((1S,1′S)-ethane-1,2-diylbis­(phenylphosphanediyl))­dibenzaldehyde ((S P,S P)-5), which is the key…”
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Iron(II)/(NH)2P2 Macrocycles: Modular, Highly Enantioselective Transfer Hydrogenation Catalysts by Bigler, Raphael, Huber, Raffael, Stöckli, Marco, Mezzetti, Antonio

“…A generalized protocol for the synthesis of chiral (NH)2P2 macrocycles allows changing the linker between the phosphines and gives access to a family of such…”
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Chiral Macrocyclic N2P2 Ligands and Iron(II): A Marriage of Interest by Bigler, Raphael, Otth, Elisabeth, Mezzetti, Antonio

“…The N2P2 macrocyclic ligands…”
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Isonitrile Iron(II) Complexes with Chiral N 2 P 2 Macrocycles in the Enantioselective Transfer Hydrogenation of Ketones by Bigler, Raphael, Mezzetti, Antonio

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ortho‐Directing Chromium Arene Complexes as Efficient Mediators for Enantiospecific C(sp2)–C(sp3) Cross‐Coupling Reactions by Bigler, Raphael, Aggarwal, Varinder K.

“…A new strategy for the coupling of a broad scope of electronically diverse aromatics to boronic esters is reported. The coupling sequence, which relies on the…”
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Highly Enantioselective Transfer Hydrogenation of Polar Double Bonds by Macrocyclic Iron(II)/(NH) 2 P 2 Catalysts by Bigler, Raphael, Mezzetti, Antonio

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Chiral Iron(II) NPPN Complexes: Synthesis and Application in the Asymmetric Strecker Reaction of Azomethine Imines by Huber, Raffael, Bigler, Raphael, Mezzetti, Antonio

“…The open-chain NPPN ligand (1S,1′S)-1,1′-((ethane-1,2-diyl­bis­(phenyl­phosphane­diyl))­bis­(2,1-phenyl­ene))­bis­(N-cyclo­hexyl­methan­imine) (1) was prepared…”
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A machine-learning tool to predict substrate-adaptive conditions for Pd-catalyzed C–N couplings by Rinehart, N. Ian, Saunthwal, Rakesh K., Wellauer, Joël, Zahrt, Andrew F., Schlemper, Lukas, Shved, Alexander S., Bigler, Raphael, Fantasia, Serena, Denmark, Scott E.

“…Machine-learning methods have great potential to accelerate the identification of reaction conditions for chemical transformations. A tool that gives…”
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New Mechanistic Insights into the Ru‐Catalyzed Asymmetric Hydrogenation of β‐Ketoesters by Püntener, Kurt, Bigler, Raphael, Stier, Kenta, Checinski, Marek P.

“…We describe the results of our quantum mechanical investigation of the asymmetric hydrogenation of β‐ketoesters catalyzed by [RuCl2(MeOH)2((R)‐MeOBIPHEP)] (7…”
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Highly Enantioselective Transfer Hydrogenation of Ketones with Chiral (NH) 2 P 2 Macrocyclic Iron(II) Complexes by Bigler, Raphael, Huber, Raffael, Mezzetti, Antonio

“…Abstract Bis(isonitrile) iron(II) complexes bearing a C 2 ‐symmetric diamino (NH) 2 P 2 macrocyclic ligand efficiently catalyze the hydrogenation of polar…”
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Synthesis of Biaryl Phosphine Palladium(0) Precatalysts by Bigler, Raphael, Spiess, Daniel, Wellauer, Joël, Binder, Martin, Carré, Victor, Fantasia, Serena

“…Well-defined palladium precatalysts have become increasingly important in cross-coupling chemistry. Despite the wide choice of complexes available today,…”
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Fit-for-Purpose Synthesis of a KRAS G12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation by Molinaro, Carmela, Wong, Nicholas, White, Nicholas A., Sirois, Lauren E., Bigler, Raphael, Bindschaedler, Quentin P., Do, Steven, Malhotra, Sushant, Gosselin, Francis

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Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation by Molinaro, Carmela, Wong, Nicholas, White, Nicholas A., Sirois, Lauren E., Bigler, Raphael, Bindschaedler, Quentin P., Do, Steven, Malhotra, Sushant, Gosselin, Francis

“…An enabling, fit-for-purpose synthesis of stereochemically pure KRASG12C covalent inhibitor 1, a potential new treatment for cancer, is described. The…”
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Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins by Bigler, Raphael, Mack, Kyle A., Shen, Jeff, Tosatti, Paolo, Han, Chong, Bachmann, Stephan, Zhang, Haiming, Scalone, Michelangelo, Pfaltz, Andreas, Denmark, Scott E., Hildbrand, Stefan, Gosselin, Francis

“…Asymmetric hydrogenation has evolved as one of the most powerful tools to construct stereocenters. However, the asymmetric hydrogenation of unfunctionalized…”
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Back Cover: Highly Enantioselective Transfer Hydrogenation of Ketones with Chiral (NH) 2 P 2 Macrocyclic Iron(II) Complexes (Angew. Chem. Int. Ed. 17/2015) by Bigler, Raphael, Huber, Raffael, Mezzetti, Antonio

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Back Cover: Highly Enantioselective Transfer Hydrogenation of Ketones with Chiral (NH)2P2 Macrocyclic Iron(II) Complexes (Angew. Chem. Int. Ed. 17/2015) by Bigler, Raphael, Huber, Raffael, Mezzetti, Antonio

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Highly Enantioselective Transfer Hydrogenation of Ketones with Chiral (NH) sub(2)P sub(2) Macrocyclic Iron(II) Complexes by Bigler, Raphael, Huber, Raffael, Mezzetti, Antonio

“…Bis(isonitrile) iron(II) complexes bearing a C sub(2)-symmetric diamino (NH) sub(2)P sub(2) macrocyclic ligand efficiently catalyze the hydrogenation of polar…”
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