Search Results - "Bigler, R D"

Use of serum soluble interleukin-2 receptor levels to monitor the progression of cutaneous T-cell lymphoma by Vonderheid, Eric C., Zhang, Qian, Lessin, Stuart R., Polansky, Marcia, Abrams, J.Todd, Bigler, Robert D., Wasik, Mariusz A.

“…Background: The serum concentration of soluble a chain of the interleukin-2 receptor (sIL-2R) correlates with tumor burden in cutaneous T-cell lymphoma (CTCL)…”
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V$\beta $-Specific Stimulation of Human T Cells by Staphylococcal Toxins by Kappler, John, Kotzin, Brian, Herron, Lynne, Gelfand, Erwin W., Bigler, Robert D., Boylston, Arthur, Carrel, Stefan, Posnett, David N., Choi, Yongwon, Marrack, Philippa

“…The staphylococcal toxins are responsible for a number of diseases in man and other animals. Many of them have also long been known to be powerful T cell…”
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Fine-needle aspiration biopsy in the evaluation of lymphadenopathy associated with cutaneous T-cell lymphoma (mycosis fungoides/Sézary syndrome) by Galindo, L M, Garcia, F U, Hanau, C A, Lessin, S R, Jhala, N, Bigler, R D, Vonderheid, E C

“…We studied the role of fine-needle aspiration (FNA) in the evaluation of lymphadenopathy associated with cutaneous T-cell lymphoma (CTCL) in 11 patients with…”
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Failure of anti-T-cell receptor V beta antibodies to consistently identify a malignant T-cell clone in Sezary syndrome by Bigler, RD, Boselli, CM, Foley, B, Vonderheid, EC

“…Monoclonal antibodies (MAbs) reacting with the human T cell receptor (TCR) V beta or V alpha region have been shown to be almost as specific as a private…”
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Autologous bone marrow transplantation for advanced stage mycosis fungoides by Bigler, R D, Crilley, P, Micaily, B, Brady, L W, Topolsky, D, Bulova, S, Vonderheid, E C, Brodsky, I

“…Patients with advanced stage cutaneous T cell lymphoma (CTCL) have a median survival of 2-5 years with no currently available curative therapy. This limited…”
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Extracorporeal photopheresis and recombinant interferon alfa 2b in Sezary syndrome. Use of dual marker labeling to monitor therapeutic response by Vonderheid, E C, Bigler, R D, Greenberg, A S, Neukum, S J, Micaily, B

“…The purpose of this pilot study was to evaluate the role of recombinant interferon alfa 2b (rIFN-a) as adjunct immunomodulatory therapy in patients with Sezary…”
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S152 (CD27). A modulating disulfide-linked T cell activation antigen by Bigler, RD, Bushkin, Y, Chiorazzi, N

“…A large subset of normal resting peripheral blood T cells express a protein at low density defined by the murine mAb S152. Reactive T cells are present in both…”
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Analysis of p53 and mdm-2 expression in 18 patients with Sézary syndrome by Marks, D I, Vonderheid, E C, Kurz, B W, Bigler, R D, Sinha, K, Morgan, D A, Sukman, A, Nowell, P C, Haines, D S

“…Sézary syndrome is a leukaemic form of cutaneous T-cell lymphoma which presents with multiple cytogenetic abnormalities and responds poorly to chemotherapy…”
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Idiotype-like molecules on cells of a human T cell leukemia by BIGLER, R. D, FISHER, D. E, WANG, C. Y, RINNOOY KAN, E. A, KUNKEL, H. G

“…Two monoclonal antibodies were obtained that showed unique specificities for the leukemic T cells used for immunization. One antibody, S160, was totally…”
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Cholesterol regulates the cell surface expression of glycophospholipid-anchored CD14 antigen on human monocytes by Esfahani, M, Bigler, R D, Alfieri, J L, Lund-Katz, S, Baum, J D, Scerbo, L

“…The CD14 antigen which is expressed on human monocytes and macrophages is a phosphatidylinositol-linked surface protein. We investigated the effects of…”
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Effect of lovastatin on cell surface expression of Fc receptors or CD14 antigen in human monocytes by Esfahani, M, Bigler, R D, Gressen, E

“…Lovastatin is a widely used anticholesterolemic drug which exercises its effect by inhibiting hepatic cholesterol synthesis and up-regulating low density…”
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Variable CD7 Expression on T Cells in the Leukemic Phase of Cutaneous T Cell Lymphoma (Sézary Syndrome) by Vonderheid, Eric C., Kotecha, Amy, Boselli, Christine M., Bigler, Robert D., Lessin, Stuart R., Bernengo, Maria Grazia, Polansky, Marcia

“…CD7, a molecule normally expressed on 90% of normal CD4+ T cells, is often deficient on the malignant T cells of cutaneous T cell lymphoma. To investigate the…”
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Identification of Low Density Lipoprotein as a Regulator of Fc Receptor-Mediated Phagocytosis by Bigler, Robert D., Khoo, Maureen, Lund-Katz, Sissel, Scerbo, Louis, Esfahani, Mojtaba

“…Optimal expression of the high-affinity Fc receptor for IgG (FcRI) by the human monocyte cell line U-937 requires the presence of low density lipoprotein…”
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Effect of low-density lipoprotein on the expression of high affinity Fc gamma receptors by Bigler, R D, Brown, H M, Guyre, P M, Lund-Katz, S, Scerbo, L, Esfahani, M

“…A substrain of the human monocyte-like cell line U937, which is a cholesterol auxotroph, was used to study the effect of cellular cholesterol depletion on the…”
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Influence of HLA genes on T cell receptor V segment frequencies and expression levels in peripheral blood lymphocytes by Akolkar, P N, Gulwani-Akolkar, B, Pergolizzi, R, Bigler, R D, Silver, J

“…The effect of the HLA complex on the TCR repertoire in human peripheral blood was assessed by using nine V beta- and V alpha-specific mAb and the quantitative…”
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Stimulation of a subset of normal resting T lymphocytes by a monoclonal antibody to a crossreactive determinant of the human T cell antigen receptor by BIGLER, R. D, POSNETT, D. N, CHIORAZZI, N

“…A previous study from this laboratory described a monoclonal antibody, S511, that reacted with the T cell antigen receptor on a human T cell leukemia and also…”
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Influence of cigarette smoking on the risk of acid pulmonary aspiration by Adelhøj, B, Petring, O U, Frøsig, F, Bigler, D R, Jensen, B N

“…Twenty-five non-smokers and 35 smokers who had abstained overnight from cigarette smoking and were undergoing minor elective orthopaedic surgery were studied…”
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T cell antiidiotypic antibodies reveal differences between two human leukemias by POSNETT, D. N, BIGLER, R. D, BUSHKIN, Y, FISHER, D. E, WANG, C. Y, MAYER, L. F, CHIORAZZI, N, KUNKEL, H. G

“…Two different human T cell leukemias were compared, using antiidiotype-like murine monoclonal antibodies. In each case these antibodies immunoprecipitated…”
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Effect of subcutaneous salbutamol on postoperative pulmonary function in patients undergoing elective cholecystectomy by Adelhøj, B, Petring, O U, Larsen, J C, Bigler, D R, Andersen, J B

“…In a double-blind study, 14 patients underwent elective cholecystectomy. The patients were randomly allocated to two groups of seven to receive either s.c…”
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Antitumor effects of interleukin-2 and mismatched double-stranded RNA, individually and in combination, against a human malignant melanoma xenograft by HUBBELL, H. R, VARGAS, H. E, TSUJIMOTO, K. L, GIBSON, G. D, PEQUIGNOT, E. C, BIGLER, R. D, CARTER, W. A, STRAYER, D. R

“…The antitumor effects of recombinant interleukin-2 (rIL-2) and mismatched double-stranded RNA (dsRNA) were assessed in tissue culture and in a nude mouse…”
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