Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats

Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats

Liver and renal dysfunction accompanying with the tissues’ oxidative damage has been reported to occur during Inflammation. Nigella sativa has been well known for its antioxidant and anti-inflammatory effects. The aim of this study was to investigate preventive effects of N. sativa on liver and rena...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation Vol. 29; no. 3; pp. 554 - 566
Main Authors: Norouzi, Fatimah, Abareshi, Azam, Khuzai, Majid, Alikhani, Vajiheh, Musawi, Sawsan, Biglari, Ghazzali, Soukhtanloo, Muhammad, Husayni, Mahmud, Beheshti, Farimah
Format: Journal Article
Language:English
Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 01-05-2018
Wolters Kluwer India Pvt. Ltd
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects:
Antioxidants
Apoptosis
Behavioral sciences
Care and treatment
Cytokines
Diabetes
Dosage and administration
Herbal medicine
Inflammation
Kidneys
Laboratory animals
Lipid peroxidation
Lipopolysaccharides
Liver
Liver diseases
Medicine
Metabolites
Nigella sativa
Prevention
Proteins
Psychiatry
Research centers
Rodents
Seeds
Sepsis
Tumor necrosis factor-TNF
Variance analysis
Iran
United States > US
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Summary:Liver and renal dysfunction accompanying with the tissues’ oxidative damage has been reported to occur during Inflammation. Nigella sativa has been well known for its antioxidant and anti-inflammatory effects. The aim of this study was to investigate preventive effects of N. sativa on liver and renal tissue damage in lipopolysaccharide (LPS)-treated rats. The rats were divided into five groups: (1) control; (2) LPS (1 mg/kg, IP, for 10 days), (3–5) N. sativa hydroethanolic extract (100, 200, or 400 mg/kg) before LPS. Compared to LPS group, treatment by the extract decreased malondialdehyde, nitric oxide (NO) metabolites, and interleukin-6 while increased thiol content and superoxide dismutase and catalase activities in both renal and liver tissues. N. sativa extract also decreased serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase concentration, while it increased serum protein and albumin compared with LPS group. In LPS group, serum blood urea nitrogen and creatinine were higher than control group. The extract reversed the negative effects of LPS. The results demonstrated that the N. sativa prevented liver and renal tissue damage in LPS-treated rats. It is suggested that the effects are due to its antioxidant and anti-inflammatory effects.
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ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.235184