Search Results - "Bigham, Michael T."

Developing a clinically feasible personalized medicine approach to pediatric septic shock by Wong, Hector R, Cvijanovich, Natalie Z, Anas, Nick, Allen, Geoffrey L, Thomas, Neal J, Bigham, Michael T, Weiss, Scott L, Fitzgerald, Julie, Checchia, Paul A, Meyer, Keith, Shanley, Thomas P, Quasney, Michael, Hall, Mark, Gedeit, Rainer, Freishtat, Robert J, Nowak, Jeffrey, Shekhar, Raj S, Gertz, Shira, Dawson, Emily, Howard, Kelli, Harmon, Kelli, Beckman, Eileen, Frank, Erin, Lindsell, Christopher J

“…Using microarray data, we previously identified gene expression-based subclasses of septic shock with important phenotypic differences. The subclass-defining…”
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Enhanced disinfection with hybrid hydrogen peroxide fogging in a critical care setting by Khandelwal, Anjay, Lapolla, Brian, Bair, Tina, Grinstead, Frances, Hislop, Meaghan, Greene, Christine, Bigham, Michael T

“…Abstract Background Environmental contamination contributes to hospital associated infections, particularly those caused by multi-drug resistant organisms…”
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Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Lindsell, Christopher J, Alder, Matthew N, Wong, Hector R

“…Abstract Background Multiple organ dysfunction syndrome (MODS) is a critical driver of sepsis morbidity and mortality in children. Early identification of…”
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Pediatric and Neonatal Interfacility Transport: Results From a National Consensus Conference by STROUD, Michael H, TRAUTMAN, Michael S, MEYER, Michael T, INSOFT, Robert, MEYER, Keith, MOSS, M. Michele, SCHWARTZ, Hamilton P, BIGHAM, Michael T, TSAROUHAS, Nicholas, WEBRA PRICE DOUGLAS, ROMITO, Janice, HAUFT, Sherrie

“…The practice of pediatric/neonatal interfacility transport continues to expand. Transport teams have evolved into mobile ICUs capable of delivering…”
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Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N, Goldstein, Stuart L, Stanski, Natalja L

“…Sepsis-associated acute kidney injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement…”
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Use of procalcitonin for the prediction and treatment of acute bacterial infection in children by Pierce, Richard, Bigham, Michael T, Giuliano, Jr, John S

“…Procalcitonin (PCT) is increasingly utilized to determine the presence of infection or to guide antibiotic therapy. This review will highlight the diagnostic…”
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Ventilator-Associated Pneumonia in the Pediatric Intensive Care Unit: Characterizing the Problem and Implementing a Sustainable Solution by Bigham, Michael T., MD, Amato, Rick, RT, Bondurrant, Pattie, RN, Fridriksson, Jon, MD, Krawczeski, Catherine D., MD, Raake, Jenni, RT, Ryckman, Sue, RN, Schwartz, Steve, MD, Shaw, Julie, RN, Wells, Dan, RT, Brilli, Richard J., MD

“…Objectives To characterize ventilator-associated pneumonia (VAP) in our pediatric intensive care unit (PICU), implement an evidence-based pediatric VAP…”
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Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1 by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N, Lahni, Patrick, Ripberger, Scarlett, Ekunwe, Adesuwa, Campbell, Kyle R, Walley, Keith R, Standage, Stephen W

“…Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition,…”
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Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model by Wong, Hector R, Weiss, Scott L, Giuliano, Jr, John S, Wainwright, Mark S, Cvijanovich, Natalie Z, Thomas, Neal J, Allen, Geoffrey L, Anas, Nick, Bigham, Michael T, Hall, Mark, Freishtat, Robert J, Sen, Anita, Meyer, Keith, Checchia, Paul A, Shanley, Thomas P, Nowak, Jeffrey, Quasney, Michael, Chopra, Arun, Fitzgerald, Julie C, Gedeit, Rainer, Banschbach, Sharon, Beckman, Eileen, Lahni, Patrick, Hart, Kimberly, Lindsell, Christopher J

“…We previously derived and validated a risk model to estimate mortality probability in children with septic shock (PERSEVERE; PEdiatRic SEpsis biomarkEr Risk…”
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Interleukin-8 as a Stratification Tool for Interventional Trials Involving Pediatric Septic Shock by Wong, Hector R, Cvijanovich, Natalie, Wheeler, Derek S, Bigham, Michael T, Monaco, Marie, Odoms, Kelli, Macias, William L, Williams, Mark D

“…Interventional clinical trials involving children with septic shock would benefit from an efficient preenrollment stratification strategy. To test the…”
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Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis by Atkinson, Sarah J, Cvijanovich, Natalie Z, Thomas, Neal J, Allen, Geoffrey L, Anas, Nick, Bigham, Michael T, Hall, Mark, Freishtat, Robert J, Sen, Anita, Meyer, Keith, Checchia, Paul A, Shanley, Thomas P, Nowak, Jeffrey, Quasney, Michael, Weiss, Scott L, Banschbach, Sharon, Beckman, Eileen, Howard, Kelli, Frank, Erin, Harmon, Kelli, Lahni, Patrick, Lindsell, Christopher J, Wong, Hector R

“…The potential benefits of corticosteroids for septic shock may depend on initial mortality risk. We determined associations between corticosteroids and…”
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The temporal version of the pediatric sepsis biomarker risk model by Wong, Hector R, Weiss, Scott L, Giuliano, Jr, John S, Wainwright, Mark S, Cvijanovich, Natalie Z, Thomas, Neal J, Allen, Geoffrey L, Anas, Nick, Bigham, Michael T, Hall, Mark, Freishtat, Robert J, Sen, Anita, Meyer, Keith, Checchia, Paul A, Shanley, Thomas P, Nowak, Jeffrey, Quasney, Michael, Chopra, Arun, Fitzgerald, Julie C, Gedeit, Rainer, Banschbach, Sharon, Beckman, Eileen, Harmon, Kelli, Lahni, Patrick, Lindsell, Christopher J

“…PERSEVERE is a risk model for estimating mortality probability in pediatric septic shock, using five biomarkers measured within 24 hours of clinical…”
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Cardiopulmonary Resuscitation in Interfacility Transport: An International Report Using the Ground Air Medical Quality in Transport (GAMUT) Database by Bigham, Michael T., Gothard, M. David, Srivastava, Neeraj, Bhalala, Utpal S.

“…Background. With the regionalization of specialty care, there is an increasing need for interfacility transport from local to regional hospitals. There are…”
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Revisiting Post-ICU Admission Fluid Balance Across Pediatric Sepsis Mortality Risk Strata: A Secondary Analysis of a Prospective Observational Cohort Study by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Abulebda, Kamal, Lutfi, Riad, Nowak, Jeffrey, Thomas, Neal J, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Sahay, Rashmi, Zhang, Bin, Alder, Matthew N, Stanski, Natalja L, Goldstein, Stuart L

“…Post-ICU admission cumulative positive fluid balance (PFB) is associated with increased mortality among critically ill patients. We sought to test whether this…”
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Opioid Reduction Through Postoperative Pain Management in Pediatric Orthopedic Surgery by Jones, Kerwyn, Engler, Laurie, Fonte, Elizabeth, Farid, Ibrahim, Bigham, Michael T

“…Our goal with this initiative was to reduce discharge opioid prescriptions while maintaining optimal pain management through the use of standardized pain…”
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Family-Centered Care in Pediatric Critical Care Transport by Joyce, Crystal N., DO, Libertin, Rachel, Bigham, Michael T., MD

“…Abstract Objective Family-centered care (FCC) in medicine highlights mutually beneficial partnerships among providers, patients, and families. In the field of…”
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Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass by Giuliano, John S., Lahni, Patrick M., Bigham, Michael T., Manning, Peter B., Nelson, David P., Wong, Hector R., Wheeler, Derek S.

“…Objective The aim was to investigate the effects of cardiopulmonary bypass (CPB) on plasma levels of the vascular growth factors, angiopoietin (angpt)-1,…”
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More than a bus ride: quality and outcomes of paediatric specialty transport by Bigham, Michael T.

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Benchmarking Pain Assessment Rate in Critical Care Transport by Reichert, Ryan J., MD, Gothard, M. David, MS, Schwartz, Hamilton P., MD, Bigham, Michael T., MD

“…Abstract The purpose of this study is to determine the rate of pain assessment in pediatric neonatal critical care transport (PNCCT). The GAMUT database was…”
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PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock by Stanski, Natalja L, Stenson, Erin K, Cvijanovich, Natalie Z, Weiss, Scott L, Fitzgerald, Julie C, Bigham, Michael T, Jain, Parag N, Schwarz, Adam, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Wong, Hector R

“…Acute kidney injury (AKI), a common complication of sepsis, is associated with substantial morbidity and mortality and lacks definitive disease-modifying…”
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