Search Results - "Bigham, E C"

2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides by Bishop, M J, Berman, J, Bigham, E C, Garrison, D T, Gobel, M J, Hodson, S J, Irving, P E, Liacos, J A, Minick, D J, Navas, F, Saussy, Jr, D L, Speake, J D

“…2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the…”
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2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase by Blumenkopf, Todd A, Harrington, Joan A, Koble, Cecilia S, Bankston, Donald D, Morrison, Robert W, Bigham, Eric C, Styles, Virgil L, Spector, Thomas

“…A series of 2-acetylpyridine thiocarbonohydrazones was synthesized for evaluation as potential antiherpetic agents. The compounds were prepared by the…”
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Synthesis and biological activity of open-chain analogs of 5,6,7,8-tetrahydrofolic acid-potential antitumor agents by Bigham, Eric C, Hodson, Stephen J, Mallory, W. Revill, Wilson, David, Duch, David S, Smith, Gary K, Ferone, Robert

“…This study describes the synthesis and in vitro antitumor activity of inhibitors of purine de novo biosynthesis that are analogues of…”
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Thienyl and Thiazolyl Acyclic Analogs of 5-Deazatetrahydrofolic Acid by Hodson, Stephen J, Bigham, Eric C, Duch, David S, Smith, Gary K, Ferone, Robert

“…Analogues of N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino] benzoyl]-L-glutamic acid (5-DACTHF), in which the phenylene group is replaced…”
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Synthetic analogs of tetrahydrobiopterin with cofactor activity for aromatic amino acid hydroxylases by Bigham, E. C, Smith, G. K, Reinhard, J. F, Mallory, W. R, Nichol, C. A, Morrison, R. W

“…Tetrahydrobiopterin (THB) analogues with 6-alkoxymethyl substituents, 3a-j, where the substituents were straight- and branched-chain alkyl ranging from methyl…”
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Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates:  New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers by Boros, Eric E, Bigham, Eric C, Boswell, G. Evan, Mook, Robert A, Patel, Sanjay S, Savarese, John J, Ray, John A, Thompson, James B, Hashim, Mir A, Wisowaty, James C, Feldman, Paul L, Samano, Vicente

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Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430:  A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates by Samano, Vicente, Ray, John A, Thompson, James B, Mook, Robert A, Jung, David K, Koble, Cecilia S, Martin, Michael T, Bigham, Eric C, Regitz, Craig S, Feldman, Paul L, Boros, Eric E

“…The stereo- and regioselective synthesis of ultra-short-acting nondepolarizing neuromuscular blocker GW 0430 (5a) is described. Key steps involved the…”
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Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis by Bigham, Eric C, Gragg, Charles E, Hall, William R, Kelsey, John E, Mallory, William R, Richardson, Drew C, Benedict, Charles, Ray, Paul H

“…Arabinose 5-phosphate ( A5P ) isomerase is a key enzyme in the biosynthesis of lipopolysaccharide, an essential component of the outer membrane of…”
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On the substrate specificity of bovine liver dihydrofolate reductase: new unconjugated dihydropterin substrates by Smith, G K, Banks, S D, Bigham, E C, Nichol, C A

“…The substrate specificity of dihydrofolate reductase from cells of different origin has been thought to be quite narrow, and unconjugated dihydropterins such…”
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New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines by Smith, G K, Duch, D S, Edelstein, M P, Bigham, E C

“…N-Acetylserotonin (compound 1) and N-acetyldopamine (compound 7) inhibit bovine adrenal medullary sepiapterin reductase in a manner competitive with the pterin…”
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In vivo antitumor activity and metabolism of a series of 5-deazaacyclotetrahydrofolate (5-DACTHF) analogues by Mullin, R J, Keith, B R, Bigham, E C, Duch, D S, Ferone, R, Heath, L S, Singer, S, Waters, K A, Wilson, H R

“…This study compares the antitumor activity and metabolism of the purine de novo biosynthesis inhibitor 5-deazaacyclotetrahydrofolate and a series of analogues…”
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Multisubstrate analogue inhibitors of glycinamide ribonucleotide transformylase based on 5-deazaacyclo tetrahydrofolate (5-DACTHF) by BIGHAM, E. C, MALLORY, W. R, HODSON, S. J, DUCH, D. S, FERONE, R, SMITH, G. K

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Neuromuscular Blocking Activity and Therapeutic Potential of Mixed-Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys by Boros, Eric E, Samano, Vicente, Ray, John A, Thompson, James B, Jung, David K, Kaldor, Istvan, Koble, Cecilia S, Martin, Michael T, Styles, Virgil L, Mook, Robert A, Feldman, Paul L, Savarese, John J, Belmont, Matthew R, Bigham, Eric C, Boswell, G. Evan, Hashim, Mir A, Patel, Sanjay S, Wisowaty, James C, Bowers, Gary D, Moseley, Caroline L, Walsh, John S, Reese, Mindy J, Rutkowske, Randy D, Sefler, Andrea M, Spitzer, Timothy D

“…Structure−activity relationships in rhesus monkeys for a novel mixed-onium class of ultra-short-acting nondepolarizing tetrahydroisoquinolinium neuromuscular…”
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New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobioterin depletion upon in vitro proliferation of two human cell lines by SMITH, G. K, DUCH, D. S, EDELSTEIN, M. P, BIGHAM, E. C

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alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines by Bishop, Michael J, Barvian, Kevin A, Berman, Judd, Bigham, Eric C, Garrison, Deanna T, Gobel, Michael J, Hodson, Stephen J, Irving, Paul E, Liacos, James A, Navas, 3rd, Frank, Saussy, David L, Speake, Jason D

“…Novel 2'-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The nature of…”
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Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines by Hodson, Stephen J, Bigham, Eric C, Garrison, Deanna T, Gobel, Michael J, Irving, Paul E, Liacos, James A, Navas, 3rd, Frank, Saussy, Jr, David L, Sherman, Bryan W, Speake, Jason D, Bishop, Michael J

“…Literature reports suggest that disruption of an interhelical salt bridge is critical for alpha(1)-adrenoceptor activation, and the basic amine found in…”
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Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates:  New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers by Boros, Eric E, Bigham, Eric C, Boswell, G. Evan, Mook, Robert A, Patel, Sanjay S, Savarese, John J, Ray, John A, Thompson, James B, Hashim, Mir A, Wisowaty, James C, Feldman, Paul L, Samano, Vicente

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Thallium in organic synthesis. 45. Synthesis of aromatic fluorides by Taylor, Edward C, Bigham, Eric C, Johnson, David K, McKillop, Alexander

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High-Throughput Manual Parallel Synthesis Using SynPhase Crowns and Lanterns by Gerritz, Samuel W, Norman, Mark H, Barger, Lee A, Berman, Judd, Bigham, Eric C, Bishop, Michael J, Drewry, David H, Garrison, Deanna T, Heyer, Dennis, Hodson, Stephen J, Kakel, Jennifer A, Linn, James A, Marron, Brian E, Nanthakumar, Suganthini S, Navas, Frank J

“…The high-throughput manual solid-phase parallel synthesis of libraries comprising thousands of discrete samples using pellicular supports (i.e. SynPhase crowns…”
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