Search Results - "Biggs, Manus"

Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies by Fernandez-Yague, Marc A., Abbah, Sunny Akogwu, McNamara, Laoise, Zeugolis, Dimitrios I., Pandit, Abhay, Biggs, Manus J.

“…The development of responsive biomaterials capable of demonstrating modulated function in response to dynamic physiological and mechanical changes in vivo…”
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Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials by Krukiewicz, Katarzyna, Britton, James, Więcławska, Daria, Skorupa, Małgorzata, Fernandez, Jorge, Sarasua, Jose-Ramon, Biggs, Manus J. P.

“…By providing a bidirectional communication channel between neural tissues and a biomedical device, it is envisaged that neural interfaces will be fundamental…”
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Responsive Biomaterials: Advances in Materials Based on Shape-Memory Polymers by Hardy, John G., Palma, Matteo, Wind, Shalom J., Biggs, Manus J.

“…Shape‐memory polymers (SMPs) are morphologically responsive materials with potential for a variety of biomedical applications, particularly as devices for…”
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Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three-Dimensional Bone Tissue Engineering by Orapiriyakul, Wich, Tsimbouri, Monica P, Childs, Peter, Campsie, Paul, Wells, Julia, Fernandez-Yague, Marc A, Burgess, Karl, Tanner, K. Elizabeth, Tassieri, Manlio, Meek, Dominic, Vassalli, Massimo, Biggs, Manus J. P, Salmeron-Sanchez, Manuel, Oreffo, Richard O. C, Reid, Stuart, Dalby, Matthew J

“…There is a pressing clinical need to develop cell-based bone therapies due to a lack of viable, autologous bone grafts and a growing demand for bone grafts in…”
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Self-supporting carbon nanotube films as flexible neural interfaces by Krukiewicz, Katarzyna, Janas, Dawid, Vallejo-Giraldo, Catalina, Biggs, Manus J.P.

“…Advances in neural interface technologies have sought to identify electroactive materials that are able to translate neural depolarisation events into digital…”
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The role of microtopography in cellular mechanotransduction by McNamara, Laura E, Burchmore, Richard, Riehle, Mathis O, Herzyk, Pawel, Biggs, Manus J.P, Wilkinson, Chris D.W, Curtis, Adam S.G, Dalby, Matthew J

“…Abstract Mechanotransduction is crucial for cellular processes including cell survival, growth and differentiation. Topographically patterned surfaces offer an…”
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Electrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: Cytocompatibility and electrochemical studies by Krukiewicz, Katarzyna, Kowalik, Agnieszka, Czerwinska-Glowka, Dominika, Biggs, Manus J.P.

“…Conducting polymers have been extensively reported as promising coating materials for applications involving interactions with electrically excitable tissues…”
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The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells by Biggs, Manus J.P, Richards, R. Geoff, Gadegaard, Nikolaj, Wilkinson, Chris D.W, Oreffo, Richard O.C, Dalby, Matthew J

“…Abstract The physiochemical characteristics of a material with in vivo applications are critical for the clinical success of the implant and regulate both…”
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In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations by Krukiewicz, Katarzyna, Kowalik, Agnieszka, Turczyn, Roman, Biggs, Manus J.P.

“…•Ibuprofen-loaded poly(3,4-ethylenedioxypyrrole) is assessed as a neural interface.•Electrochemically superior material is formed via a three-step…”
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Biofunctionalisation of electrically conducting polymers by Vallejo-Giraldo, Catalina, Kelly, Adriona, Biggs, Manus J.P.

“…•Increasing the use of multifaceted strategies for the functionalisation of conducting polymers in tissue-engineering applications.•Long-term performance and…”
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Nanotopographical modification: a regulator of cellular function through focal adhesions by Biggs, Manus Jonathan Paul, PhD, Richards, R. Geoff, PhD, Dalby, Matthew J., PhD

“…Abstract As materials technology and the field of biomedical engineering advances, the role of cellular mechanisms, in particular adhesive interactions with…”
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The Functional Response of Mesenchymal Stem Cells to Electron‐Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity by Biggs, Manus J. P., Fernandez, Marc, Thomas, Dilip, Cooper, Ryan, Palma, Matteo, Liao, Jinyu, Fazio, Teresa, Dahlberg, Carl, Wheadon, Helen, Pallipurath, Anuradha, Pandit, Abhay, Kysar, Jeffrey, Wind, Shalom J.

“…Cells directly probe and respond to the physicomechanical properties of their extracellular environment, a dynamic process which has been shown to play a key…”
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A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels by Fernandez‐Yague, Marc A., Trotier, Alexandre, Demir, Secil, Abbah, Sunny Akogwu, Larrañaga, Aitor, Thirumaran, Arun, Stapleton, Aimee, Tofail, Syed A. M., Palma, Matteo, Kilcoyne, Michelle, Pandit, Abhay, Biggs, Manus J.

“…Tendon disease constitutes an unmet clinical need and remains a critical challenge in the field of orthopaedic surgery. Innovative solutions are required to…”
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Interactions with nanoscale topography: Adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage by Biggs, Manus J. P., Richards, R. Geoff, Gadegaard, Nikolaj, McMurray, Rebecca J., Affrossman, Stanley, Wilkinson, Chris D. W., Oreffo, Richard O. C., Dalby, Mathew J.

“…Polymeric medical devices widely used in orthopedic surgery play key roles in fracture fixation and orthopedic implant design. Topographical modification and…”
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Flexible, Transparent, and Cytocompatible Nanostructured Indium Tin Oxide Thin Films for Bio-optoelectronic Applications by Krukiewicz, Katarzyna, Czerwińska-Główka, Dominika, Turczyn, Roman Maria, Blacha-Grzechnik, Agata, Vallejo-Giraldo, Catalina, Erfurt, Karol, Chrobok, Anna, Faure-Vincent, Jérôme, Pouget, Stéphanie, Djurado, David, Biggs, Manus J.P.

“…Electrical stimulation has been used successfully for several decades for the treatment of neurodegenerative disorders, including motor disorders, pain, and…”
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Diatoms: a biotemplating approach to fabricating drug delivery reservoirs by Chao, Joshua T, Biggs, Manus J P, Pandit, Abhay S

“…Biotemplating is a rapidly expanding subfield that utilizes nature-inspired systems and structures to create novel functional materials, and it is through…”
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A flexible strain-responsive sensor fabricated from a biocompatible electronic ink via an additive-manufacturing process by Britton, James, Krukiewicz, Katarzyna, Chandran, Malu, Fernandez, Jorge, Poudel, Anup, Sarasua, Jose-Ramon, FitzGerald, Una, Biggs, Manus J.P.

“…[Display omitted] •We developed strain-responsive biosensors from biocompatible conductive polymer inks.•We developed a scalable additive manufacturing process…”
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Nanocellulose reinforced gellan-gum hydrogels as potential biological substitutes for annulus fibrosus tissue regeneration by Pereira, Diana R., Silva-Correia, Joana, Oliveira, Joaquim M., Reis, Rui L., Pandit, Abhay, Biggs, Manus J.

“…Intervertebral disc (IVD) degeneration is associated with both structural damage and aging related degeneration. Annulus fibrosus (AF) defects such as annular…”
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Chirality-sorted carbon nanotube films as high capacity electrode materials by Krukiewicz, Katarzyna, Krzywiecki, Maciej, Biggs, Manus J P, Janas, Dawid

“…Carbon nanomaterials show great promise for a wide range of applications due to their excellent physicochemical and electrical properties. Since their…”
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The effect of annealing on the mechanical properties and microstructural evolution of Ti-rich NiTi shape memory alloy by Tadayyon, Ghazal, Mazinani, Mohammad, Guo, Yina, Zebarjad, Seyed Mojtaba, Tofail, Syed A.M., Biggs, Manus J.

“…An investigation was carried out into the influence of the annealing temperatures on the thermo-mechanical behavior of Ti-rich NiTi alloy with regard to…”
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