Search Results - "Biggs, Leah C."

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage by Nava, Michele M., Miroshnikova, Yekaterina A., Biggs, Leah C., Whitefield, Daniel B., Metge, Franziska, Boucas, Jorge, Vihinen, Helena, Jokitalo, Eija, Li, Xinping, García Arcos, Juan Manuel, Hoffmann, Bernd, Merkel, Rudolf, Niessen, Carien M., Dahl, Kris Noel, Wickström, Sara A.

“…Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei,…”
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Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function by Biggs, Leah C., Kim, Christine S., Miroshnikova, Yekaterina A., Wickström, Sara A.

“…Tissue shape emerges from the collective mechanical properties and behavior of individual cells and the ways by which they integrate into the surrounding…”
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Early inductive events in ectodermal appendage morphogenesis by Biggs, Leah C., Mikkola, Marja L.

“…•The vertebrate ectoderm gives rise to a wide variety of organs known as ectodermal appendages.•Ectodermal appendage development is guided by…”
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Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche by Binder, Martin, Chmielarz, Piotr, Mckinnon, Peter J., Biggs, Leah C., Thesleff, Irma, Balic, Anamaria

“…Continuous growth of the mouse incisor teeth is due to the life‐long maintenance of epithelial stem cells (SCs) in their niche called cervical loop (CL)…”
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Transforming growth factor Beta 3 is required for excisional wound repair in vivo by Le, Mark, Naridze, Rachelle, Morrison, Jasmine, Biggs, Leah C, Rhea, Lindsey, Schutte, Brian C, Kaartinen, Vesa, Dunnwald, Martine

“…Wound healing is a complex process that relies on proper levels of cytokines and growth factors to successfully repair the tissue. Of particular interest are…”
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Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation by Binder, Martin, Biggs, Leah C., Kronenberg, Mark S., Schneider, Pascal, Thesleff, Irma, Balic, Anamaria

“…Enamel is secreted by ameloblasts derived from tooth epithelial stem cells (SCs). Humans cannot repair or regenerate enamel, due to early loss of tooth…”
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Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation by Biggs, Leah C, Mäkelä, Otto Jm, Myllymäki, Satu-Marja, Das Roy, Rishi, Närhi, Katja, Pispa, Johanna, Mustonen, Tuija, Mikkola, Marja L

“…Mesenchymal condensation is a critical step in organogenesis, yet the underlying molecular and cellular mechanisms remain poorly understood. The hair follicle…”
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Interferon regulatory factor 6 regulates keratinocyte migration by Biggs, Leah C, Naridze, Rachelle L, DeMali, Kris A, Lusche, Daniel F, Kuhl, Spencer, Soll, David R, Schutte, Brian C, Dunnwald, Martine

“…Interferon regulatory factor 6 (Irf6) regulates keratinocyte proliferation and differentiation. In this study, we tested the hypothesis that Irf6 regulates…”
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Nuclear mechanotransduction on skin stem cell fate regulation by Biggs, Leah C., Miroshnikova, Yekaterina A.

“…Mammalian skin is a highly dynamic and regenerative organ that has long been recognized as a mechanically active composite of tissues withstanding daily…”
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Wound Healing Goes Viral by Boylan, Louis W., Biggs, Leah C.

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Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle by Kim, Christine S., Ding, Xiaolei, Allmeroth, Kira, Biggs, Leah C., Kolenc, Olivia I., L’Hoest, Nina, Chacón-Martínez, Carlos Andrés, Edlich-Muth, Christian, Giavalisco, Patrick, Quinn, Kyle P., Denzel, Martin S., Eming, Sabine A., Wickström, Sara A.

“…Stem cells reside in specialized niches that are critical for their function. Upon activation, hair follicle stem cells (HFSCs) exit their niche to generate…”
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Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation by Shirokova, Vera, Biggs, Leah C., Jussila, Maria, Ohyama, Takahiro, Groves, Andrew K., Mikkola, Marja L.

“…The hair follicle is an ideal system to study stem cell specification and homeostasis due to its well characterized morphogenesis and stereotypic cycles of…”
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Palatogenesis and cutaneous repair: A two‐headed coin by Biggs, Leah C., Goudy, Steven L., Dunnwald, Martine

“…ABSTRACT Background: The reparative mechanism that operates following post‐natal cutaneous injury is a fundamental survival function that requires a…”
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Interferon Regulatory Factor 6 Is Necessary, but Not Sufficient, for Keratinocyte Differentiation by Biggs, Leah C., Rhea, Lindsey, Schutte, Brian C., Dunnwald, Martine

“…Regulation of epidermal proliferation and differentiation is critical for maintenance of cutaneous homeostasis. Interferon Regulatory Factor 6 (Irf6)-deficient…”
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Interferon regulatory factor 6 is required for proper wound healing in vivo by Rhea, Lindsey, Canady, Franklin J., Le, Marc, Reeb, Tanner, Canady, John W., Kacmarynski, Deborah S. F., Avvari, Rishika, Biggs, Leah C., Dunnwald, Martine

“…Background Van der Woude syndrome (VWS) is the most common form of syndromic orofacial cleft caused predominantly by mutations in Interferon Regulatory Factor…”
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Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome-wide association on chromosome 1p22 by Leslie, Elizabeth J., Mansilla, M. Adela, Biggs, Leah C., Schuette, Kristi, Bullard, Steve, Cooper, Margaret, Dunnwald, Martine, Lidral, Andrew C., Marazita, Mary L., Beaty, Terri H., Murray, Jeffrey C.

“…BACKGROUND Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect with complex etiology reflecting the action of multiple…”
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Finding Closure: Regulated Irf6 Expression is Required for Proper Wound Healing In Vivo by Reeb, Tanner, Canady, Franklin J, Tesdahl, Brennan, Biggs, Leah C, Dunnwald, Martine

“…Abstract only Chronic wounds affect 6.5 million people in the US, yet little is known about the genetic and molecular mechanisms regulating wound healing…”
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Interferon Regulatory Factor 6, a novel transcriptional regulator of embryonic development and wound healing by Biggs, Leah C, Le, Mark, Rhea, Lindsey, Kinoshita, Akira, Murray, Jeff C, Schutte, Brian C, Dunnwald, Martine

“…Abstract only Cleft lip and palate (CLP) constitutes the second most common congenital birth defects in the US. This complex trait results from a disruption of…”
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