Search Results - "Biggs, Judith A"

A Spontaneously Arising Pancreatic Tumor Does Not Promote the Differentiation of Naive CD8+ T Lymphocytes into Effector CTL by Lyman, Michael A, Aung, Sandra, Biggs, Judith A, Sherman, Linda A

“…In this report, we address whether a growing tumor provides sufficient inflammatory signals to promote activation, clonal expansion, and acquisition of…”
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The Fate of Low Affinity Tumor-Specific CD8+ T Cells in Tumor-Bearing Mice by Lyman, Michael A, Nugent, C. Thomas, Marquardt, Kristi L, Biggs, Judith A, Pamer, Eric G, Sherman, Linda A

“…A major challenge in tumor immunology is how best to activate the relatively low avidity self-specific and tumor-specific T cells that are available in the…”
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Altered functional and biochemical response by CD8+ T cells that remain after tolerance by Murtaza, Anwar, Nugent, C. Thomas, Tailor, Pankaj, Asensio, Valerie C., Biggs, Judith A., Campbell, Iain L., Sherman, Linda A.

“…To further define the molecular basis of tolerance to a peripherally expressed antigen we have correlated differences in functional capacity with biochemical…”
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Characterization of CD8+ T Lymphocytes That Persist After Peripheral Tolerance to a Self Antigen Expressed in the Pancreas by Nugent, C. Thomas, Morgan, David J, Biggs, Judith A, Ko, Alice, Pilip, Ingrid M, Pamer, Eric G, Sherman, Linda A

“…As a result of expression of the influenza hemagglutinin (HA) in the pancreatic islets, the repertoire of HA-specific CD8+ T lymphocytes in InsHA transgenic…”
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Defective CD8+ T Cell Peripheral Tolerance in Nonobese Diabetic Mice by Kreuwel, Huub T. C, Biggs, Judith A, Pilip, Ingrid M, Pamer, Eric G, Lo, David, Sherman, Linda A

“…Nonobese diabetic (NOD) mice develop spontaneous autoimmune diabetes that involves participation of both CD4+ and CD8+ T cells. Previous studies have…”
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Alloantibodies can Discriminate Class I Major Histocompatibility Complex Molecules Associated with Various Endogenous Peptides by Sherman, Linda A., Chattopadhyay, Suschmitta, Biggs, Judith A., Dick, Robert F., Bluestone, Jeffrey A.

“…Molecules encoded by a single major histocompatibility complex class I gene can associate with any one of a large number of peptide ligands. T-cell receptors…”
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Using gamma‐cytokine complexes to improve antigen specific CD8 T cell responses in tumor‐bearing mice by Verdeil, Gregory, Marquardt, Kristi L, Biggs, Judith A, Surh, Charles D, Sherman, Linda A

“…Abstract only In the absence of inflammatory signals, the exposure of T cells to tumor antigen in the periphery results in tolerance. Remaining tumor specific…”
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A Spontaneously Arising Pancreatic Tumor Does Not Promote the Differentiation of Naive CD8 super(+) T Lymphocytes into Effector CTL by Lyman, Michael A, Aung, Sandra, Biggs, Judith A, Sherman, Linda A

“…In this report, we address whether a growing tumor provides sufficient inflammatory signals to promote activation, clonal expansion, and acquisition of…”
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The Fate of Low Affinity Tumor-Specific CD8 super(+) T Cells in Tumor-Bearing Mice by Lyman, Michael A, Nugent, CThomas, Marquardt, Kristi L, Biggs, Judith A, Pamer, Eric G, Sherman, Linda A

“…A major challenge in tumor immunology is how best to activate the relatively low avidity self-specific and tumor-specific T cells that are available in the…”
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Extracellular processing of peptide antigens that bind class I major histocompatibility molecules by SHERMAN, L. A, BURKE, T. A, BIGGS, J. A

“…One problem associated with the use of synthetic peptides as antigens in vivo is their susceptibility to inactivation by proteolytic degradation. A situation…”
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