Search Results - "Bigg, Heather F."

Activity of matrix metalloproteinase‐9 against native collagen types I and III by Bigg, Heather F., Rowan, Andrew D., Barker, Michael D., Cawston, Tim E.

“…Interstitial collagen types I, II and III are highly resistant to proteolytic attack, due to their triple helical structure, but can be cleaved by matrix…”
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The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation by Bigg, Heather F., Wait, Robin, Rowan, Andrew D., Cawston, Tim E.

“…YKL-40 is expressed in arthritic cartilage and produced in large amounts by cultured chondrocytes, but its exact role is unclear, and the identities of its…”
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Identification, regulation and role of tissue inhibitor of metalloproteinases‐4 (TIMP‐4) in human platelets by Radomski, Anna, Jurasz, Paul, Sanders, Esmond J, Overall, Christopher M, Bigg, Heather F, Edwards, Dylan R, Radomski, Marek W

“…Matrix metalloproteinase‐2 (MMP‐2) released during activation of human platelets by aggregating agents and cancer cells is known to stimulate platelet…”
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Cellular Activation of MMP-2 (Gelatinase A) by MT2-MMP Occurs via a TIMP-2-independent Pathway by Morrison, Charlotte J., Butler, Georgina S., Bigg, Heather F., Roberts, Clive R., Soloway, Paul D., Overall, Christopher M.

“…The role of membrane-type (MT) 2-matrix metalloproteinase (MMP) in the cellular activation of MMP-2 and the tissue inhibitor of matrix metalloproteinase (TIMP)…”
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Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase by BIGG, Heather F, MORRISON, Charlotte J, BUTLER, Georgina S, BOGOYEVITCH, Marie A, ZHIPING WANG, SOLOWAY, Paul D, OVERALL, Christopher M

“…The tissue inhibitors of metalloproteinases 1-4 (TIMPs) have discrete regulatory roles in the activation of matrix metalloproteinase (MMP)-2 (gelatinase A), an…”
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Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2 by Toth, Marta, Bernardo, M. Margarida, Gervasi, David C., Soloway, Paul D., Wang, Zhiping, Bigg, Heather F., Overall, Christopher M., DeClerck, Yves A., Tschesche, Harald, Cher, Michael L., Brown, Stephen, Mobashery, Shahriar, Fridman, Rafael

“…The membrane-type 1 matrix metalloproteinase (MT1-MMP) has been shown to be a key enzyme in tumor angiogenesis and metastasis. MT1-MMP hydrolyzes a variety of…”
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The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis by Bigg, Heather F, Rowan, A.D

“…The collagenases of the matrix metalloproteinase family are key enzymes in mediating irreversible cartilage collagen loss in arthritis. Inhibition of these…”
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The Involvement of the Fibronectin Type II-like Modules of Human Gelatinase A in Cell Surface Localization and Activation by Steffensen, Bjorn, Bigg, Heather F., Overall, Christopher M.

“…Recombinant collagen-binding domain (rCBD) comprising the three fibronectin type II-like modules of human gelatinase A was found to compete the zymogen form of…”
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Domain Interactions in the Gelatinase A·TIMP-2·MT1-MMP Activation Complex by Overall, Christopher M., Tam, Eric, McQuibban, G. Angus, Morrison, Charlotte, Wallon, U. Margaretha, Bigg, Heather F., King, Angela E., Roberts, Clive R.

“…On the cell surface, the 59-kDa membrane type 1-matrix metalloproteinase (MT1-MMP) activates the 72-kDa progelatinase A (MMP-2) after binding the tissue…”
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Specific, High Affinity Binding of Tissue Inhibitor of Metalloproteinases-4 (TIMP-4) to the COOH-terminal Hemopexin-like Domain of Human Gelatinase A by Bigg, Heather F., Shi, Y. Eric, Liu, Yiliang E., Steffensen, Bjorn, Overall, Christopher M.

“…The binding properties of the newly described tissue inhibitor of metalloproteinases-4 (TIMP-4) to progelatinase A and to the COOH-terminal hemopexin-like…”
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Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels by Ridley, SH, Sarsfield, SJ, Lee, JC, Bigg, HF, Cawston, TE, Taylor, DJ, DeWitt, DL, Saklatvala, J

“…The role of p38 mitogen-activated protein kinase (MAPK) in responses of human fibroblasts and vascular endothelial cells to IL-1 was investigated by use of a…”
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Domain Interactions in the Gelatinase A·TIMP-2·MT1-MMP Activation Complex by Christopher M. Overall, Eric Tam, G. Angus McQuibban, Charlotte Morrison, U. Margaretha Wallon, Heather F. Bigg, Angela E. King, Clive R. Roberts

“…On the cell surface, the 59-kDa membrane type 1-matrix metalloproteinase (MT1-MMP) activates the 72-kDa progelatinase A (MMP-2) after binding the tissue…”
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Paper alert: Pharmacology by Khakh, Baljit, Dickenson, Tony, Flavahan, Nicholas, Chatterjee, Prabal, Thiemermann, Chris, Newton, Robert, Lindsay, Mark, Bigg, Heather F, Rowan, A.D, Futscher, Bernard, Perretti, Mauro, Hoffman, Paul, Brady, Gerard, Sharkey, Keith, MacNaughton, Wallace, Furman, Brian

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Effect of retinoic acid in combination with platelet-derived growth factor-BB or transforming growth factor-β on tissue inhibitor of metalloproteinases and collagenase secretion from human skin and synovial fibroblasts by Bigg, Heather F., Cawston, Tim E.

“…This report shows for the first time that platelet‐derived growth factor‐BB (PDGF‐BB) and transforming growth factor‐β (TGF‐β) can interact in a synergistic…”
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All-Trans-Retinoic Acid Interacts Synergistically with Basic Fibroblast Growth Factor and Epidermal Growth Factor to Stimulate the Production of Tissue Inhibitor of Metalloproteinases from Fibroblasts by Bigg, H.F., Cawston, T.E.

“…This report examines the effect of all-trans-retinoic acid in combination with basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF) on…”
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Identification of the TIMP-2 Binding Site on the Gelatinase A Hemopexin C-Domain by Site-Directed Mutagenesis and the Yeast Two-Hybrid System by OVERALL, CHRISTOPHER M., KING, ANGELA E., BIGG, HEATHER F., McQUIBBAN, ANGUS, ATHERSTONE, JULIET, SAM, DOUGLAS K., ONG, ALDRICH D., LAU, TIM T.Y., WALLON, U. MARGARETHA, DeCLERCK, YVES A., TAM, ERIC

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Induction of Human Tissue Inhibitor of Metalloproteinase-1 Gene Expression by All-trans Retinoic Acid in Combination with Basic Fibroblast Growth Factor Involves both p42/44 and p38 MAP Kinases by BIGG, HEATHER F., McLEOD, RONNIE, WATERS, JASMINE, CAWSTON, TIM E., NOLAN, JOHN F., CLARK, IAN M.

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Mechanisms of induction of human tissue inhibitor of metalloproteinases‐1 (TIMP‐1) gene expression by all‐trans retinoic acid in combination with basic fibroblast growth factor by Bigg, Heather F., McLeod, Ronnie, Waters, Jasmine G., Cawston, Tim E., Clark, Ian M.

“…The addition of all‐trans retinoic acid (ATRA) in combination with basic fibroblast growth factor (bFGF) to human fibroblasts results in a synergistic…”
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Recombinant Porcine Collagenase: Purification and Autolysis by Clark, I.M., Mitchell, R.E., Powell, L.K., Bigg, H.F., Cawston, T.E., Ohare, M.C.

“…Collagenase is a member of the matrix metalloproteinase family whose members are all capable of degrading extracellular matrix components. The mature form of…”
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Fragments of human fibroblast collagenase: interaction with metalloproteinase inhibitors and substrates by Bigg, H F, Clark, I M, Cawston, T E

“…On purification, active human fibroblast collagenase breaks down by an autolytic mechanism into two major forms (M(r) 22,000 and M(r) 27,000) and one minor…”
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