Search Results - "Bigelow, George E."

Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia by Oh, Esther S, Blennow, Kaj, Bigelow, George E, Inouye, Sharon K, Marcantonio, Edward R, Neufeld, Karin J, Rosenberg, Paul B, Troncoso, Juan C, Wang, Nae-Yuh, Zetterberg, Henrik, Sieber, Frederick E, Lyketsos, Constantine G

“…There is strong association of Alzheimer's disease (AD) pathology with gait disorder and falls in older adults without dementia. The goal of the study was to…”
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Analgesic Effects of Hydromorphone versus Buprenorphine in Buprenorphine-maintained Individuals by Huhn, Andrew S., Strain, Eric C., Bigelow, George E., Smith, Michael T., Edwards, Robert R., Tompkins, D. Andrew

“…WHAT WE ALREADY KNOW ABOUT THIS TOPIC WHAT THIS ARTICLE TELLS US THAT IS NEW BACKGROUND:Managing acute pain in buprenorphine-maintained individuals in…”
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Extended‐release injectable naltrexone for opioid use disorder: a systematic review by Jarvis, Brantley P., Holtyn, August F., Subramaniam, Shrinidhi, Tompkins, D. Andrew, Oga, Emmanuel A., Bigelow, George E., Silverman, Kenneth

“…Aims To review systematically the published literature on extended‐release naltrexone (XR‐NTX, Vivitrol®), marketed as a once‐per‐month injection product to…”
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Effects of repeated tramadol and morphine administration on psychomotor and cognitive performance in opioid-dependent volunteers by Mintzer, Miriam Z, Lanier, Ryan K, Lofwall, Michelle R, Bigelow, George E, Strain, Eric C

“…Abstract Tramadol is an atypical, mixed mechanism analgesic used to treat moderate to severe pain. Based on evidence that tramadol has relatively low abuse…”
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Pharmacodynamic effects of vaporized and oral cannabidiol (CBD) and vaporized CBD-dominant cannabis in infrequent cannabis users by Spindle, Tory R., Cone, Edward J., Goffi, Elia, Weerts, Elise M., Mitchell, John M., Winecker, Ruth E., Bigelow, George E., Flegel, Ronald R., Vandrey, Ryan

“…•Pharmacodynamics were assessed for oral/vaporized CBD and CBD-dominant cannabis.•100 mg vaporized pure cannabidiol (CBD) produced discriminable subjective…”
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Pharmacokinetic Profile of Oral Cannabis in Humans: Blood and Oral Fluid Disposition and Relation to Pharmacodynamic Outcomes by Vandrey, Ryan, Herrmann, Evan S, Mitchell, John M, Bigelow, George E, Flegel, Ronald, LoDico, Charles, Cone, Edward J

“…Most research on cannabis pharmacokinetics has evaluated inhaled cannabis, but oral ("edible") preparations comprise an increasing segment of the cannabis…”
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A Reinforcement-Based Therapeutic Workplace for the Treatment of Drug Abuse: Three-Year Abstinence Outcomes by Silverman, Kenneth, Svikis, Dace, Wong, Conrad J, Hampton, Jacqueline, Stitzer, Maxine L, Bigelow, George E

“…Long-term Therapeutic Workplace effects were evaluated in heroin- and cocaine-dependent, unemployed, treatment-resistant young mothers. Participants were paid…”
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Acute Pharmacokinetic Profile of Smoked and Vaporized Cannabis in Human Blood and Oral Fluid by Spindle, Tory R, Cone, Edward J, Schlienz, Nicolas J, Mitchell, John M, Bigelow, George E, Flegel, Ronald, Hayes, Eugene, Vandrey, Ryan

“…Currently, an unprecedented number of individuals can legally access cannabis. Vaporization is increasingly popular as a method to self-administer cannabis,…”
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Acute Effects of Smoked and Vaporized Cannabis in Healthy Adults Who Infrequently Use Cannabis: A Crossover Trial by Spindle, Tory R, Cone, Edward J, Schlienz, Nicolas J, Mitchell, John M, Bigelow, George E, Flegel, Ronald, Hayes, Eugene, Vandrey, Ryan

“…Vaporization is an increasingly popular method for cannabis administration, and policy changes have increased adult access to cannabis drastically. Controlled…”
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Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial by Sieber, Frederick E, Neufeld, Karin J, Gottschalk, Allan, Bigelow, George E, Oh, Esther S, Rosenberg, Paul B, Mears, Simon C, Stewart, Kerry J, Ouanes, Jean-Pierre P, Jaberi, Mahmood, Hasenboehler, Erik A, Li, Tianjing, Wang, Nae-Yuh

“…Postoperative delirium is the most common complication following major surgery in older patients. Intraoperative sedation levels are a possible modifiable risk…”
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Pharmacodynamic dose effects of oral cannabis ingestion in healthy adults who infrequently use cannabis by Schlienz, Nicolas J., Spindle, Tory R., Cone, Edward J., Herrmann, Evan S., Bigelow, George E., Mitchell, John M., Flegel, Ronald, LoDico, Charles, Vandrey, Ryan

“…•Pharmacodynamics were assessed for oral cannabis containing 0, 10, 25, and 50 mg THC.•10 mg THC produced discriminable subjective effects but no cognitive…”
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Naloxone formulation for overdose reversal preference among patients receiving opioids for pain management by Dunn, Kelly E., Barrett, Frederick S., Bigelow, George E.

“…Opioid-related overdose has increased 137% in the past decade. Training nonmedical bystanders to administer naloxone (Narcan™) is a widely-researched…”
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Depth of sedation as an interventional target to reduce postoperative delirium: mortality and functional outcomes of the Strategy to Reduce the Incidence of Postoperative Delirium in Elderly Patients randomised clinical trial by Sieber, Frederick, Neufeld, Karin J, Gottschalk, Allan, Bigelow, George E, Oh, Esther S, Rosenberg, Paul B, Mears, Simon C, Stewart, Kerry J, Ouanes, Jean-Pierre P, Jaberi, Mahmood, Hasenboehler, Erik A, Wang, Nae-Yuh

“…The Strategy to Reduce the Incidence of Postoperative Delirium in the Elderly trial tested the hypothesis that limiting sedation during spinal anaesthesia…”
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Food and Drug Administration approval of sustained‐release buprenorphine for treatment of opioid dependence: realizing its potential by Sigmon, Stacey C., Bigelow, George E.

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Urinary Pharmacokinetic Profile of Cannabinoids Following Administration of Vaporized and Oral Cannabidiol and Vaporized CBD-Dominant Cannabis by Spindle, Tory R, Cone, Edward J, Kuntz, David, Mitchell, John M, Bigelow, George E, Flegel, Ronald, Vandrey, Ryan

“…Abstract Cannabis products in which cannabidiol (CBD) is the primary chemical constituent (CBD-dominant) are increasingly popular and widely available. The…”
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Efficacy of Tramadol Extended-Release for Opioid Withdrawal: A Randomized Clinical Trial by Dunn, Kelly E, Tompkins, D Andrew, Bigelow, George E, Strain, Eric C

“…Opioid use disorder (OUD) is a significant public health problem. Supervised withdrawal (ie, detoxification) from opioids using clonidine or buprenorphine…”
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Clinical pharmacology of buprenorphine: ceiling effects at high doses by Walsh, S L, Preston, K L, Stitzer, M L, Cone, E J, Bigelow, G E

“…The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial mu-agonist, across a wide range of doses in comparison to…”
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Opioid Overdose History, Risk Behaviors, and Knowledge in Patients Taking Prescribed Opioids for Chronic Pain by Dunn, Kelly E., Barrett, Frederick S., Fingerhood, Michael, Bigelow, George E.

“…Abstract Objective. More than 100 million adults in the United States experience chronic pain, and prescription opioids are the third most widely prescribed…”
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Randomized controlled trial of a computerized opioid overdose education intervention by Dunn, Kelly E, Yepez-Laubach, Claudia, Nuzzo, Paul A, Fingerhood, Michael, Kelly, Anne, Berman, Suzan, Bigelow, George E

“…Highlights • Randomized controlled comparison of three methods to deliver overdose education. • All methods produced knowledge increases that were sustained…”
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Individual differences in human opioid abuse potential as observed in a human laboratory study by Dunn, Kelly E., Barrett, Frederick S., Brands, Bruna, Marsh, David C., Bigelow, George E.

“…•Little is known about the differences in how individuals experience opioids.•Study examined differences from 2 opioids, 4 doses, and 2 routes of…”
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