Search Results - "Bigelow, Diana J."

Diet-induced obesity reprograms the inflammatory response of the murine lung to inhaled endotoxin by Tilton, Susan C., Waters, Katrina M., Karin, Norman J., Webb-Robertson, Bobbie-Jo M., Zangar, Richard C., Lee, K. Monica, Bigelow, Diana J., Pounds, Joel G., Corley, Richard A.

“…The co-occurrence of environmental factors is common in complex human diseases and, as such, understanding the molecular responses involved is essential to…”
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3-Nitrotyrosine Modification of SERCA2a in the Aging Heart:  A Distinct Signature of the Cellular Redox Environment by Knyushko, Tatyana V, Sharov, Victor S, Williams, Todd D, Schöneich, Christian, Bigelow, Diana J

“…In the aging heart, decreased rates of calcium transport mediated by the SERCA2a isoform of the sarcoplasmic reticulum (SR) Ca-ATPase are responsible for the…”
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A Method for Selective Enrichment and Analysis of Nitrotyrosine-Containing Peptides in Complex Proteome Samples by Zhang, Qibin, Qian, Wei-Jun, Knyushko, Tatyana V, Clauss, Therese R. W, Purvine, Samuel O, Moore, Ronald J, Sacksteder, Colette A, Chin, Mark H, Smith, Desmond J, Camp, David G, Bigelow, Diana J, Smith, Richard D

“…Elevated levels of protein tyrosine nitration have been found in various neurodegenerative diseases and age-related pathologies. Until recently, however, the…”
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Identification of a Denitrase Activity against Calmodulin in Activated Macrophages Using High-Field Liquid Chromatography−FTICR Mass Spectrometry by Smallwood, Heather S, Lourette, Natacha M, Boschek, Curt B, Bigelow, Diana J, Smith, Richard D, Paša-Tolić, Ljiljana, Squier, Thomas C

“…We have identified a denitrase activity in macrophages that is upregulated following macrophage activation, which is shown by mass spectrometry to recognize…”
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Sites of Proteolytic Processing and Noncovalent Association of the Distal C-Terminal Domain of CaV1.1 Channels in Skeletal Muscle by Hulme, Joanne T., Konoki, Keiichi, Teddy W.-C. Lin, Gritsenko, Marina A., Camp, David G., Bigelow, Diana J., Catterall, William A.

“…In skeletal muscle cells, voltage-dependent potentiation of Ca2+qchannel activity requires phosphorylation by cAMP-dependent protein kinase (PKA) anchored via…”
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Concerted but Noncooperative Activation of Nucleotide and Actuator Domains of the Ca-ATPase upon Calcium Binding by Chen, Baowei, Mahaney, James E, Mayer, M. Uljana, Bigelow, Diana J, Squier, Thomas C

“…Calcium-dependent domain movements of the actuator (A) and nucleotide (N) domains of the SERCA2a isoform of the Ca-ATPase were assessed using constructs…”
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Phospholamban Modulates the Functional Coupling between Nucleotide Domains in Ca-ATPase Oligomeric Complexes in Cardiac Sarcoplasmic Reticulum by Chen, Linda T. L, Yao, Qing, Soares, Thereza A, Squier, Thomas C, Bigelow, Diana J

“…Oligomeric interactions between Ca-ATPase polypeptide chains and their modulation by phospholamban (PLB) were measured in native cardiac sarcoplasmic reticulum…”
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Targeted Releasable Affinity Probe (TRAP) for In Vivo Photocrosslinking by Yan, Ping, Wang, Ting, Newton, Gregory J, Knyushko, Tatyana V, Xiong, Yijia, Bigelow, Diana J, Squier, Thomas C, Mayer, M. Uljana

“…A protein TRAP: The in vivo photocrosslinking of TRAP after its intracellular targeting to a binding sequence on the bait protein stabilizes protein…”
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Cellular trafficking of phospholamban and formation of functional sarcoplasmic reticulum during myocyte differentiation by Stenoien, David L, Knyushko, Tatyana V, Londono, Monica P, Opresko, Lee K, Mayer, M Uljana, Brady, Scott T, Squier, Thomas C, Bigelow, Diana J

“…Phospholamban (PLB) associates with the Ca(2+)-ATPase in sarcoplasmic reticulum (SR) membranes to permit the modulation of contraction in response to…”
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Calcium Occupancy of N-Terminal Sites within Calmodulin Induces Inhibition of the Ryanodine Receptor Calcium Release Channel by Boschek, Curt B, Jones, Terry E, Squier, Thomas C, Bigelow, Diana J

“…Calmodulin (CaM) regulates calcium release from intracellular stores in skeletal muscle through its association with the ryanodine receptor (RyR1) calcium…”
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Nitrotyrosine-modified SERCA2: a cellular sensor of reactive nitrogen species by Bigelow, Diana J.

“…The endo-/sarcoplasmic reticulum Ca 2+ –Mg 2+ -adenosine triphosphatase (SERCA2) isoform of the sarco/endoplasmic reticulum Ca 2+ -ATPase is sensitive to…”
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Redox modulation of cellular signaling and metabolism through reversible oxidation of methionine sensors in calcium regulatory proteins by Bigelow, Diana J., Squier, Thomas C.

“…Adaptive responses associated with environmental stressors are critical to cell survival. Under conditions when cellular redox and antioxidant defenses are…”
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Thioredoxin-dependent redox regulation of cellular signaling and stress response through reversible oxidation of methionines by Bigelow, Diana J, Squier, Thomas C

“…The sensitive oxidations of sulfur containing amino acids (i.e., cysteines and methionines) commonly control protein function, and act as important signaling…”
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Quantitative site-specific reactivity profiling of S-nitrosylation in mouse skeletal muscle using cysteinyl peptide enrichment coupled with mass spectrometry by Su, Dian, Shukla, Anil K., Chen, Baowei, Kim, Jong-Seo, Nakayasu, Ernesto, Qu, Yi, Aryal, Uma, Weitz, Karl, Clauss, Therese R.W., Monroe, Matthew E., Camp II, David G., Bigelow, Diana J., Smith, Richard D., Kulkarni, Rohit N., Qian, Wei-Jun

“…S-nitrosylation, the formation of S-nitrosothiol (SNO), is an important reversible thiol oxidation event that has been increasingly recognized for its role in…”
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Smoking, COPD, and 3-Nitrotyrosine Levels of Plasma Proteins by Jin, Hongjun, Webb-Robertson, Bobbie-Jo, Peterson, Elena S., Tan, Ruimin, Bigelow, Diana J., Scholand, Mary Beth, Hoidal, John R., Pounds, Joel G., Zangar, Richard C.

“…Background: Nitric oxide is a physiological regulator of endothelial function and hemodynamics. Oxidized products of nitric oxide can form nitrotyrosine, which…”
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Synthesis and Application of an Environmentally Insensitive Cy3-Based Arsenical Fluorescent Probe To Identify Adaptive Microbial Responses Involving Proximal Dithiol Oxidation by Fu, Na, Su, Dian, Cort, John R, Chen, Baowei, Xiong, Yijia, Qian, Wei-Jun, Konopka, Allan E, Bigelow, Diana J, Squier, Thomas C

“…Reversible disulfide oxidation between proximal cysteines in proteins represents a common regulatory control mechanism to modulate flux through metabolic…”
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A halotyrosine antibody that detects increased protein modifications in asthma patients by Jin, Hongjun, Hallstrand, Teal S., Daly, Don S., Matzke, Melissa M., Nair, Parameswaran, Bigelow, Diana J., Pounds, Joel G., Zangar, Richard C.

“…Airway inflammation has a pathophysiological role in asthma. Eosinophils, which are commonly increased in asthmatic airways, express eosinophil peroxidase and…”
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Controlled Activation of Protein Rotational Dynamics Using Smart Hydrogel Tethering by Beech, Brenda M, Xiong, Yijia, Boschek, Curt B, Baird, Cheryl L, Bigelow, Diana J, McAteer, Kathleen, Squier, Thomas C

“…Stimulus-responsive hydrogel materials that stabilize and control protein dynamics have the potential to enable a range of applications that take advantage of…”
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Region-Specific Protein Abundance Changes in the Brain of MPTP-Induced Parkinson’s Disease Mouse Model by Zhang, Xu, Zhou, Jian-Ying, Chin, Mark H, Schepmoes, Athena A, Petyuk, Vladislav A, Weitz, Karl K, Petritis, Brianne O, Monroe, Matthew E, Camp, David G, Wood, Stephen A, Melega, William P, Bigelow, Diana J, Smith, Desmond J, Qian, Wei-Jun, Smith, Richard D

“…Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration in the nigrostriatal region of the brain; however, the neurodegeneration extends…”
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Targeted Protein Degradation of Outer Membrane Decaheme Cytochrome MtrC Metal Reductase in Shewanella oneidensis MR-1 Measured Using Biarsenical Probe CrAsH-EDT2 by Xiong, Yijia, Chen, Baowei, Shi, Liang, Fredrickson, James K, Bigelow, Diana J, Squier, Thomas C

“…Development of efficient microbial biofuel cells requires an ability to exploit interfacial electron transfer reactions to external electron acceptors, such as…”
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