Search Results - "Bigay, Joëlle"

Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact sites by de la Mora, Eugenio, Dezi, Manuela, Di Cicco, Aurélie, Bigay, Joëlle, Gautier, Romain, Manzi, John, Polidori, Joël, Castaño-Díez, Daniel, Mesmin, Bruno, Antonny, Bruno, Lévy, Daniel

“…Membrane contact sites (MCS) are subcellular regions where two organelles appose their membranes to exchange small molecules, including lipids. Structural…”
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Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein by Jézéquel, Gwenaëlle, Rampal, Céline, Guimard, Carole, Kovacs, David, Polidori, Joël, Bigay, Joëlle, Bignon, Jérôme, Askenatzis, Laurie, Litaudon, Marc, Pham, Van-Cuong, Huong, Doan T. M., Nguyen, Anvi Laetitia, Pruvost, Alain, Virolle, Thierry, Mesmin, Bruno, Desrat, Sandy, Antonny, Bruno, Roussi, Fanny

“…Schweinfurthins (SWs) are naturally occurring prenylated stilbenes with promising anticancer properties. They act through a novel mechanism of action similar…”
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Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein by Strating, Jeroen R.P.M., van der Linden, Lonneke, Albulescu, Lucian, Bigay, Joëlle, Arita, Minetaro, Delang, Leen, Leyssen, Pieter, van der Schaar, Hilde M., Lanke, Kjerstin H.W., Thibaut, Hendrik Jan, Ulferts, Rachel, Drin, Guillaume, Schlinck, Nina, Wubbolts, Richard W., Sever, Navdar, Head, Sarah A., Liu, Jun O., Beachy, Philip A., De Matteis, Maria A., Shair, Matthew D., Olkkonen, Vesa M., Neyts, Johan, van Kuppeveld, Frank J.M.

“…Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this study, we identify ITZ as a broad-spectrum inhibitor of…”
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Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor by Péresse, Tiphaine, Kovacs, David, Subra, Mélody, Bigay, Joëlle, Tsai, Meng-Chen, Polidori, Joël, Gautier, Romain, Desrat, Sandy, Fleuriot, Lucile, Debayle, Delphine, Litaudon, Marc, Pham, Van-Cuong, Bignon, Jérôme, Antonny, Bruno, Roussi, Fanny, Mesmin, Bruno

“…ORPphilins are bioactive natural products that strongly and selectively inhibit the growth of some cancer cell lines and are proposed to target intracellular…”
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Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity by Bigay, Joëlle, Antonny, Bruno

“…Whereas some rare lipids contribute to the identity of cell organelles, we focus on the abundant lipids that form the matrix of organelle membranes…”
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Two Lipid-Packing Sensor Motifs Contribute to the Sensitivity of ArfGAP1 to Membrane Curvature by Mesmin, Bruno, Drin, Guillaume, Levi, Sharon, Rawet, Moran, Cassel, Dan, Bigay, Joëlle, Antonny, Bruno

“…ArfGAP1 (Arf GTPase activating protein 1) controls the cycling of the COPI coat on Golgi membranes by catalyzing GTP hydrolysis in the small G protein Arf1…”
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The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol by Antonny, Bruno, Bigay, Joëlle, Mesmin, Bruno

“…To maintain an asymmetric distribution of ions across membranes, protein pumps displace ions against their concentration gradient by using chemical energy…”
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Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP by Mesmin, Bruno, Bigay, Joëlle, Polidori, Joël, Jamecna, Denisa, Lacas‐Gervais, Sandra, Antonny, Bruno

“…The network of proteins that orchestrate the distribution of cholesterol among cellular organelles is not fully characterized. We previously proposed that…”
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A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP by Mesmin, Bruno, Bigay, Joëlle, Moser von Filseck, Joachim, Lacas-Gervais, Sandra, Drin, Guillaume, Antonny, Bruno

“…Several proteins at endoplasmic reticulum (ER)-Golgi membrane contact sites contain a PH domain that interacts with the Golgi phosphoinositide PI(4)P, a FFAT…”
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An Intrinsically Disordered Region in OSBP Acts as an Entropic Barrier to Control Protein Dynamics and Orientation at Membrane Contact Sites by Jamecna, Denisa, Polidori, Joël, Mesmin, Bruno, Dezi, Manuela, Levy, Daniel, Bigay, Joëlle, Antonny, Bruno

“…Lipid transfer proteins (LTPs) acting at membrane contact sites (MCS) between the ER and other organelles contain domains involved in heterotypic (e.g., ER to…”
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Poliovirus Evolution toward Independence from the Phosphatidylinositol‑4 Kinase III β/Oxysterol-Binding Protein Family I Pathway by Arita, Minetaro, Bigay, Joëlle

“…Phosphatidylinositol-4 kinase III β (PI4KB) and oxysterol-binding protein (OSBP) family I provide a conserved host pathway required for enterovirus…”
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Molecular mechanisms of perilipin protein function in lipid droplet metabolism by Griseti, Elena, Bello, Abdoul Akim, Bieth, Eric, Sabbagh, Bayane, Iacovoni, Jason S., Bigay, Joëlle, Laurell, Henrik, Čopič, Alenka

“…Perilipins are abundant lipid droplet (LD) proteins present in all metazoans and also in Amoebozoa and fungi. Humans express five perilipins, which share a…”
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Role of Protein-Phospholipid Interactions in the Activation of ARF1 by the Guanine Nucleotide Exchange Factor Arno by Paris, Sonia, Béraud-Dufour, Sophie, Robineau, Sylviane, Bigay, Joëlle, Antonny, Bruno, Chabre, Marc, Chardin, Pierre

“…Arno is a 47-kDa human protein recently identified as a guanine nucleotide exchange factor for ADP ribosylation factor 1 (ARF1) with a central Sec7 domain…”
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α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding by Pranke, Iwona M, Morello, Vincent, Bigay, Joëlle, Gibson, Kimberley, Verbavatz, Jean-Marc, Antonny, Bruno, Jackson, Catherine L

“…Membrane curvature sensors have diverse structures and chemistries, suggesting that they might have the intrinsic capacity to discriminate between different…”
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Surface tension-driven sorting of human perilipins on lipid droplets by Dias Araújo, Ana Rita, Bello, Abdoul Akim, Bigay, Joëlle, Franckhauser, Céline, Gautier, Romain, Cazareth, Julie, Kovács, Dávid, Brau, Frédéric, Fuggetta, Nicolas, Čopič, Alenka, Antonny, Bruno

“…Perilipins (PLINs), the most abundant proteins on lipid droplets (LDs), display similar domain organization including amphipathic helices (AH). However, the…”
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VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites by Subra, Mélody, Dezi, Manuela, Bigay, Joëlle, Lacas-Gervais, Sandra, Di Cicco, Aurélie, Araújo, Ana Rita Dias, Abélanet, Sophie, Fleuriot, Lucile, Debayle, Delphine, Gautier, Romain, Patel, Amanda, Roussi, Fanny, Antonny, Bruno, Lévy, Daniel, Mesmin, Bruno

“…Membrane contact sites (MCSs) are heterogeneous in shape, composition, and dynamics. Despite this diversity, VAP proteins act as receptors for multiple FFAT…”
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Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature by Antonny, Bruno, Bigay, Joëlle, Gounon, Pierre, Robineau, Sylviane

“…Protein coats deform flat lipid membranes into buds and capture membrane proteins to form transport vesicles. The assembly/disassembly cycle of the COPI coat…”
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A lipid exchange market : vectorial cholesterol transport by the protein OSBP by Bigay, Joëlle, Mesmin, Bruno, Antonny, Bruno

“…Cholesterol is synthesized in the endoplasmic reticulum (RE) and then transported to cellular compartments whose functions require high cholesterol levels…”
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Building lipid 'PIPelines' throughout the cell by ORP/Osh proteins by Moser von Filseck, Joachim, Mesmin, Bruno, Bigay, Joëlle, Antonny, Bruno, Drin, Guillaume

“…In eukaryotic cells, a sterol gradient exists between the early and late regions of the secretory pathway. This gradient seems to rely on non-vesicular…”
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Roles of Lipid Modifications of Transducin Subunits in Their GDP-Dependent Association and Membrane Binding by Bigay, Joelle, Faurobert, Eva, Franco, Michel, Chabre, Marc

“…Transducin is an unusually soluble and dissociable heterotrimeric G-protein, although its T alpha and T beta gamma subunits are N-acylated and farnesylated,…”
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