Search Results - "Bigarella, Carolina L."

Stem cells and the impact of ROS signaling by Bigarella, Carolina L, Liang, Raymond, Ghaffari, Saghi

“…An appropriate balance between self-renewal and differentiation is crucial for stem cell function during both early development and tissue homeostasis…”
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FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage by Bigarella, Carolina L., Li, Jianfeng, Rimmelé, Pauline, Liang, Raymond, Sobol, Robert W., Ghaffari, Saghi

“…Accumulation of damaged DNA in hematopoietic stem cells (HSC) is associated with chromosomal abnormalities, genomic instability, and HSC aging and might…”
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A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis by Liang, Raymond, Campreciós, Genís, Kou, Yan, McGrath, Kathleen, Nowak, Roberta, Catherman, Seana, Bigarella, Carolina L, Rimmelé, Pauline, Zhang, Xin, Gnanapragasam, Merlin Nithya, Bieker, James J, Papatsenko, Dmitri, Ma'ayan, Avi, Bresnick, Emery, Fowler, Velia, Palis, James, Ghaffari, Saghi

“…Circulating red blood cells (RBCs) are essential for tissue oxygenation and homeostasis. Defective terminal erythropoiesis contributes to decreased generation…”
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Crosstalk Between Reticular Adherens Junctions and Platelet Endothelial Cell Adhesion Molecule-1 Regulates Endothelial Barrier Function by Fernández-Martín, Laura, Marcos-Ramiro, Beatriz, Bigarella, Carolina L, Graupera, Mariona, Cain, Robert J, Reglero-Real, Natalia, Jiménez, Anaïs, Cernuda-Morollón, Eva, Correas, Isabel, Cox, Susan, Ridley, Anne J, Millán, Jaime

“…OBJECTIVE—Endothelial cells provide a barrier between the blood and tissues, which is reduced during inflammation to allow selective passage of molecules and…”
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Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells by Rimmelé, Pauline, Bigarella, Carolina L., Liang, Raymond, Izac, Brigitte, Dieguez-Gonzalez, Rebeca, Barbet, Gaetan, Donovan, Michael, Brugnara, Carlo, Blander, Julie M., Sinclair, David A., Ghaffari, Saghi

“…Aging hematopoietic stem cells (HSCs) exhibit defective lineage specification that is thought to be central to increased incidence of myeloid malignancies and…”
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The CATS (FAM64A) protein is a substrate of the Kinase Interacting Stathmin (KIS) by Archangelo, Leticia Fröhlich, Greif, Philipp A., Maucuer, Alexandre, Manceau, Valérie, Koneru, Naresh, Bigarella, Carolina L., Niemann, Fernanda, dos Santos, Marcos Tadeu, Kobarg, Jörg, Bohlander, Stefan K., Saad, Sara Teresinha Olalla

“…The CATS protein (also known as FAM64A and RCS1) was first identified as a novel CALM (PICALM) interactor that influences the subcellular localization of the…”
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Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells by Liang, Raymond, Rimmelé, Pauline, Bigarella, Carolina L., Yalcin, Safak, Ghaffari, Saghi

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Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3 by Rimmelé, Pauline, Liang, Raymond, Bigarella, Carolina L, Kocabas, Fatih, Xie, Jingjing, Serasinghe, Madhavika N, Chipuk, Jerry, Sadek, Hesham, Zhang, Cheng Cheng, Ghaffari, Saghi

“…Hematopoietic stem cells (HSC) are primarily dormant but have the potential to become highly active on demand to reconstitute blood. This requires a swift…”
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Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells by Liang, Raymond, Rimmelé, Pauline, Bigarella, Carolina L, Yalcin, Safak, Ghaffari, Saghi

“…Transcription factors FOXOs (1, 3, 4) are essential for the maintenance of haematopoietic stem cells. FOXOs are evolutionary conserved substrates of the AKT…”
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Fibrillin-1 microfibrils influence adult bone marrow hematopoiesis by Smaldone, Silvia, Bigarella, Carolina L., del Solar, Maria, Ghaffari, Saghi, Ramirez, Francesco

“…We have recently demonstrated that fibrillin-1 assemblies regulate the fate of skeletal stem cells (aka, mesenchymal stem cells [MSCs]) by modulating TGFβ…”
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ARHGAP21 Protein, a New Partner of α-Tubulin Involved in Cell-Cell Adhesion Formation and Essential for Epithelial-Mesenchymal Transition by Barcellos, Karin S.A., Bigarella, Carolina L., Wagner, Mark V., Vieira, Karla P., Lazarini, Mariana, Langford, Peter R., Machado-Neto, João A., Call, Steven G., Staley, Davis M., Chung, Jarom Y., Hansen, Marc D., Saad, Sara T.O.

“…Cell-cell adhesions and the cytoskeletons play important and coordinated roles in cell biology, including cell differentiation, development, and migration…”
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Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3 by Bigarella, Carolina L., Vieira Ferro, Karla P., Barcellos, Karin S.A., Martins-de-Souza, Daniel, Traina, Fabiola, Novello, José C., Olalla Saad, Sara T., Archangelo, Leticia Fröhlich

“…► ARHGAP21 has a higher molecular weight form. ► ARHGAP21 suffers post-translational modification by SUMO2 and SUMO3. ► ARHGAP21 is SUMOylated in highly…”
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CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation by Price, Jeremy G, Idoyaga, Juliana, Salmon, Hélène, Hogstad, Brandon, Bigarella, Carolina L, Ghaffari, Saghi, Leboeuf, Marylene, Merad, Miriam

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Loss of Foxo3 Reduces Erythroblast Apoptosis and Enhances RBC Production in Beta-Thalassemic Mice by Liang, Raymond, Campreciós, Genís, Bigarella, Carolina L., Ghaffari, Saghi

“…β-thalassemia arises as a result of mutations in the β-globin gene. As a consequence erythropoiesis, the process that insures the daily generation of billions…”
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CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation by Price, Jeremy G, Idoyaga, Juliana, Salmon, Hélène, Hogstad, Brandon, Bigarella, Carolina L, Ghaffari, Saghi, Leboeuf, Marylene, Merad, Miriam

“…Treatment with ionizing radiation can lead to the accumulation of tumor-infiltrating T reg cells. Merad and colleagues show that Langherans cells resist…”
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CDKN1A regulates Langerhans cell survival and promotes [T.sub.reg] cell generation upon exposure to ionizing irradiation by Price, Jeremy G, Idoyaga, Juliana, Salmon, Helene, Hogstad, Brandon, Bigarella, Carolina L, Ghaffari, Saghi, Leboeuf, Marylene, Merad, Miriam

“…Treatment with ionizing radiation (IR) can lead to the accumulation of tumor-infiltrating regulatory T cells ([T.sub.reg] cells) and subsequent resistance of…”
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CDKN1A regulates Langerhans cell survival and promotes T sub(reg) cell generation upon exposure to ionizing irradiation by Price, Jeremy G, Idoyaga, Juliana, Salmon, Helene, Hogstad, Brandon, Bigarella, Carolina L, Ghaffari, Saghi, Leboeuf, Marylene, Merad, Miriam

“…Treatment with ionizing radiation (IR) can lead to the accumulation of tumor-infiltrating regulatory T cells (T sub(reg) cells) and subsequent resistance of…”
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The cell cycle inhibitor Cdkn1a regulates Langerhans cell radiation resistance and promotes T regulatory cell generation upon exposure to ionizing irradiation by Price, Jeremy G., Idoyaga, Juliana, Salmon, Hélène, Hogstad, Brandon, Bigarella, Carolina L., Ghaffari, Saghi, Leboeuf, Marylene, Merad, Miriam

“…Treatment with ionizing irradiation (IR) may lead to accumulation of tumor-infiltrating T regulatory (T reg ) cells and subsequent tumor resistance to…”
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Loss Of p53 Rescues The Defective Function Of Foxo3-/- Hematopoietic Stem Cells But Enhances Their Predisposition To Malignancy by Bigarella, Carolina L., Rimmele, Pauline, Dieguez-Gonzalez, Rebeca, Liang, Raymond, Izac, Brigitte, Papatsenko, Dmitri, Ghaffari, Saghi

“…Leukemic stem cells (LSCs) share many of the same properties of normal hematopoietic stem cells (HSCs) including their highly quiescent state, capacity to…”
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CXCR7 Participates in Chemotaxis and Homing Mediated By CXCL12 by Melo, Rita de Cassia Carvalho, Xavier-Ferrucio, Juliana M., Ricon, Lauremilia, Ferro, Karla Priscila Vieira Vieira, Bigarella, Carolina L., Franchi, Gilberto C., Nowill, Alexandre, Saad, Sara Teresinha Olalla

“…Hematopoiesis is tightly orchestrated by a precise quiescence/cycling equilibrium that is required for the continuous controlled production of differentiated…”
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