Search Results - "Bigam, David L"

Reassessing selection criteria prior to liver transplantation for hepatocellular carcinoma utilizing the scientific registry of transplant recipients database by Toso, Christian, Asthana, Sonal, Bigam, David L., Shapiro, A. M. James, Kneteman, Norman M.

“…The current model of liver graft allocation in place in the United States favors transplantation of patients with small hepatocellular carcinomas (HCCs) within…”
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Barriers to the Interpretation of Body Composition in Colorectal Cancer: A Review of the Methodological Inconsistency and Complexity of the CT-Defined Body Habitus by Hopkins, Jessica J., Skubleny, Daniel, Bigam, David L., Baracos, Vickie E., Eurich, Dean T., Sawyer, Michael B.

“…Background Measurement of body composition by computed tomography (CT) is an advancing field. Sarcopenia, myosteatosis, and visceral obesity (VO) have been…”
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Surgical outcomes and quality of life following exercise-based prehabilitation for hepato-pancreatico-biliary surgery: A systematic review and meta-analysis by Deprato, Andy, Verhoeff, Kevin, Purich, Kieran, Kung, Janice Y, Bigam, David L, Dajani, Khaled Z

“…Hepato-pancreatico-biliary (HPB) patients experience significant risk of preoperative frailty. Studies assessing preventative prehabilitation in HPB…”
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Clearance of transaminases during normothermic ex situ liver perfusion by Bral, Mariusz, Aboelnazar, Nader, Hatami, Sanaz, Thiesen, Aducio, Bigam, David L, Freed, Darren H, Shapiro, A M James

“…One of the most promising applications of liver normothermic machine perfusion (NMP) is the potential to directly assess graft viability and injury. In most…”
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The Transition to Microsurgical Technique for Hepatic Artery Reconstruction in Pediatric Liver Transplantation by Nickel, Kevin J., Staples, John, Meeberg, Glenda, Kwan, Peter O., Gilmour, Susan, Bigam, David L., Dajani, Khaled, Shapiro, A. M. James, Kneteman, Norman M., Ladak, Adil

“…Hepatic artery thrombosis represents a potentially fatal complication following liver transplantation. Rates of hepatic artery thrombosis are significantly…”
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Avoiding initial hypothermia does not improve liver graft quality in a porcine donation after circulatory death (DCD) model of normothermic perfusion by Nostedt, Jordan J, Churchill, Tom, Ghosh, Sunita, Thiesen, Aducio, Hopkins, Jessica, Lees, Mackenzie C, Adam, Benjamin, Freed, Darren H, Shapiro, A M James, Bigam, David L

“…Normothermic machine perfusion (NMP) of liver grafts donated after circulatory death (DCD) has shown promise in large animal and clinical trials. Following…”
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Preclinical models of acute liver failure: a comprehensive review by Hefler, Joshua, Marfil-Garza, Braulio A, Pawlick, Rena L, Freed, Darren H, Karvellas, Constantine J, Bigam, David L, Shapiro, A M James

“…Acute liver failure is marked by the rapid deterioration of liver function in a previously well patient over period of days to weeks. Though relatively rare,…”
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Exhaled CO2 Parameters as a Tool to Assess Ventilation-Perfusion Mismatching during Neonatal Resuscitation in a Swine Model of Neonatal Asphyxia by Li, Elliott Shang-shun, Cheung, Po-Yin, O'Reilly, Megan, LaBossiere, Joseph, Lee, Tze-Fun, Cowan, Shaun, Bigam, David L, Schmölzer, Georg Marcus

“…End-tidal CO2 (ETCO2), partial pressure of exhaled CO2 (PECO2), and volume of expired CO2 (VCO2) can be continuously monitored non-invasively to reflect…”
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Model of Acute Liver Failure in an Isolated Perfused Porcine Liver—Challenges and Lessons Learned by Hefler, Joshua, Hatami, Sanaz, Thiesen, Aducio, Olafson, Carly, Durand, Kiarra, Acker, Jason, Karvellas, Constantine J, Bigam, David L, Freed, Darren H, Shapiro, Andrew Mark James

“…Acute liver failure (ALF) is a rare but devastating disease associated with substantial morbidity and a mortality rate of almost 45%. Medical treatments, apart…”
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Evaluating Islet Cell Isolation and Transplantation From Donors Following Medical Assistance in Dying by Parente, Alessandro, Verhoeff, Kevin, Kin, Tatsuya, Hefler, Joshua, Marfil-Garza, Braulio A, Sanchez-Fernandez, Norberto, Lam, Anna, Lyon, James, O'Gorman, Doug, Dajani, Khaled Z, Anderson, Blaire L, Bigam, David L, MacDonald, Patrick E, Shapiro, A M James

“…Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors. We…”
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Liver Transplantation in Locally Unresectable, Undifferentiated Embryonal Cell Sarcoma by Babu, Benoy I., Bigam, David L., Gilmour, Susan M., Dajani, Khaled Z., Shapiro, A.M. James, Kneteman, Norman M.

“…Undifferentiated embryonal cell sarcoma (UESL) of the liver is the third most common malignant liver disease of childhood presenting as a rapidly enlarging…”
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Sirolimus drug-eluting, hydrogel-impregnated polypropylene mesh reduces intra-abdominal adhesion formation in a mouse model by Maciver, Allison H., MD, McCall, Michael D., MD, Edgar, Ryan L., BSc, Thiesen, Aducio L., MD, PhD, Bigam, David L., MD, MSc, Churchill, Thomas A., PhD, Shapiro, A.M. James, MD, PhD

“…Background Prosthetic mesh is used frequently in abdominal wall hernia reconstruction but is prone to postoperative adhesion formation. Complications resulting…”
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Strategic opportunities in clinical islet transplantation by Shapiro, A M James, Lakey, Jonathan R T, Paty, Breay W, Senior, Peter A, Bigam, David L, Ryan, Edmond A

“…More than 471 patients with type 1 diabetes have received islet transplants at 43 institutions worldwide in the past 5 years. High rates of insulin…”
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Cyclosporine treatment reduces oxygen free radical generation and oxidative stress in the brain of hypoxia-reoxygenated newborn piglets by Gill, Richdeep S, Lee, Tze-Fun, Liu, Jiang-Qin, Chaudhary, Hetal, Brocks, Dion R, Bigam, David L, Cheung, Po-Yin

“…Oxygen free radicals have been implicated in the pathogenesis of hypoxic-ischemic encephalopathy. It has previously been shown in traumatic brain injury animal…”
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The Impact of Muscle and Adipose Tissue on Long-term Survival in Patients With Stage I to III Colorectal Cancer by Hopkins, Jessica J, Reif, Rebecca L, Bigam, David L, Baracos, Vickie E, Eurich, Dean T, Sawyer, Michael B

“…BACKGROUND:Computed tomography-derived body composition parameters are emerging prognostic factors in colorectal cancer. OBJECTIVE:This study aimed to…”
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Effects of post-resuscitation treatment with N-acetylcysteine on cardiac recovery in hypoxic newborn piglets by Liu, Jiang-Qin, Lee, Tze-Fun, Bigam, David L, Cheung, Po-Yin

“…Although N-acetylcysteine (NAC) can decrease reactive oxygen species and improve myocardial recovery after ischemia/hypoxia in various acute animal models,…”
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Cost‐utility analysis of normothermic machine perfusion compared to static cold storage in liver transplantation in the Canadian setting by Webb, Alexandria N., Lester, Erica L. W., Shapiro, Andrew Mark James, Eurich, Dean T., Bigam, David L.

“…To estimate the incremental cost‐effectiveness of a liver transplant program that utilizes normothermic machine perfusion (NMP) alongside static cold storage…”
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Impact of hypoalbuminemia on outcomes following pancreaticoduodenectomy: a NSQIP retrospective cohort analysis of 25,848 patients by Sawchuk, Taylor, Verhoeff, Kevin, Jogiat, Uzair, Mocanu, Valentin, Shapiro, A. M. James, Anderson, Blaire, Dajani, Khaled, Bigam, David L.

“…Background Efforts to preoperatively risk stratify and optimize patients before pancreaticoduodenectomy continue to improve outcomes. This study aims to…”
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Persistent hyperbilirubinemia following preoperative biliary stenting in patients undergoing anatomic hepatectomy predicts serious complications by Kirkland, Megan, Verhoeff, Kevin, Jogiat, Uzair, Mocanu, Valentin, Shapiro, A. M. James, Anderson, Blaire, Bigam, David L., Dajani, Khaled

“…Background Biliary obstruction before liver resection is a known risk factor for post-operative complications. The aim of this study was to determine the…”
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Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets by Liu, Jiang-Qin, Manouchehri, Namdar, Lee, Tze-Fun, Yao, Mingzhu, Bigam, David L, Cheung, Po-Yin

“…The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates. The aim of the…”
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