Search Results - "Biette, Kelly"

Transmembrane Substrate Determinants for γ‑Secretase Processing of APP CTFβ by Fernandez, Marty A, Biette, Kelly M, Dolios, Georgia, Seth, Divya, Wang, Rong, Wolfe, Michael S

“…The amyloid β-peptide (Aβ) of Alzheimer’s disease (AD) is generated by proteolysis within the transmembrane domain (TMD) of a C-terminal fragment of the…”
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Signal Integration by Shadow Enhancers and Enhancer Duplications Varies across the Drosophila Embryo by Scholes, Clarissa, Biette, Kelly M., Harden, Timothy T., DePace, Angela H.

“…Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter…”
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Hypoxia drives transient site-specific copy gain and drug-resistant gene expression by Black, Joshua C, Atabakhsh, Elnaz, Kim, Jaegil, Biette, Kelly M, Van Rechem, Capucine, Ladd, Brendon, Burrowes, Paul D, Donado, Carlos, Mattoo, Hamid, Kleinstiver, Benjamin P, Song, Bing, Andriani, Grasiella, Joung, J Keith, Iliopoulos, Othon, Montagna, Cristina, Pillai, Shiv, Getz, Gad, Whetstine, Johnathan R

“…Copy number heterogeneity is a prominent feature within tumors. The molecular basis for this heterogeneity remains poorly characterized. Here, we demonstrate…”
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Yearly Planning Meetings: Individualized Development Plans Aren’t Just More Paperwork by Vincent, Ben J., Scholes, Clarissa, Staller, Max V., Wunderlich, Zeba, Estrada, Javier, Park, Jeehae, Bragdon, Meghan D.J., Lopez Rivera, Francheska, Biette, Kelly M., DePace, Angela H.

“…The National Institutes of Health (NIH) encourages trainees to make Individualized Development Plans to help them prepare for academic and nonacademic careers…”
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Hunchback is counter-repressed to regulate even-skipped stripe 2 expression in Drosophila embryos by Vincent, Ben J, Staller, Max V, Lopez-Rivera, Francheska, Bragdon, Meghan D J, Pym, Edward C G, Biette, Kelly M, Wunderlich, Zeba, Harden, Timothy T, Estrada, Javier, DePace, Angela H

“…Hunchback is a bifunctional transcription factor that can activate and repress gene expression in Drosophila development. We investigated the regulatory DNA…”
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Colocalization of Cancer-Associated Biomarkers on Single Extracellular Vesicles for Early Detection of Cancer by Salem, Daniel P., Bortolin, Laura T., Gusenleitner, Dan, Grosha, Jonian, Zabroski, Ibukunoluwapo O., Biette, Kelly M., Banerjee, Sanchari, Sedlak, Christopher R., Byrne, Delaney M., Hamzeh, Bilal F., King, MacKenzie S., Cuoco, Lauren T., Santos-Heiman, Timothy, Barcaskey, Gabrielle N., Yang, Katherine S., Duff, Peter A., Winn-Deen, Emily S., Guettouche, Toumy, Mattoon, Dawn R., Huang, Eric K., Schekman, Randy W., Couvillon, Anthony D., Sedlak, Joseph C.

“…Detection of cancer early, when it is most treatable, remains a significant challenge because of the lack of diagnostic methods sufficiently sensitive to…”
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Transcriptional kinetic synergy: A complex landscape revealed by integrating modeling and synthetic biology by Martinez-Corral, Rosa, Park, Minhee, Biette, Kelly M, Friedrich, Dhana, Scholes, Clarissa, Khalil, Ahmad S, Gunawardena, Jeremy, DePace, Angela H

“…Transcription factors (TFs) control gene expression, often acting synergistically. Classical thermodynamic models offer a biophysical explanation for synergy…”
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Semi-automated hydrophobic interaction chromatography column scouting used in the two-step purification of recombinant green fluorescent protein by Stone, Orrin J, Biette, Kelly M, Murphy, Patrick J M

“…Hydrophobic interaction chromatography (HIC) most commonly requires experimental determination (i.e., scouting) in order to select an optimal chromatographic…”
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Quantitative Measurement and Thermodynamic Modeling of Fused Enhancers Support a Two-Tiered Mechanism for Interpreting Regulatory DNA by Samee, Md. Abul Hassan, Lydiard-Martin, Tara, Biette, Kelly M., Vincent, Ben J., Bragdon, Meghan D., Eckenrode, Kelly B., Wunderlich, Zeba, Estrada, Javier, Sinha, Saurabh, DePace, Angela H.

“…Computational models of enhancer function generally assume that transcription factors (TFs) exert their regulatory effects independently, modeling an enhancer…”
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Whole exome sequencing analysis of inter‐participant cortisol response: strategies for matching phenotype to genotype (983.1) by Murphy, Patrick, Biette, Kelly

“…The overarching goal of this project is to identify genetic variants that are indicative of an individual’s systemic and intracellular responses to…”
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Initial results from a dose finding study of TNO155, a SHP2 inhibitor, in adults with advanced solid tumors by Brana, Irene, Shapiro, Geoffrey, Johnson, Melissa Lynne, Yu, Helena Alexandra, Robbrecht, Debbie, Tan, Daniel Shao-Weng, Siu, Lillian L., Minami, Hironobu, Steeghs, Neeltje, Hengelage, Thomas, Tan, Eugene, Biette, Kelly, Xu, Kun, Moody, Susan Elizabeth, Jove, Maria

“…Abstract only 3005 Background: SHP2 transduces signals from activated receptor tyrosine kinases to downstream pathways including MAPK. TNO155 is a selective,…”
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Extracellular vesicle-based biomarker assay for the detection of early-stage ovarian cancer by Bortolin, Laura, Salem, Daniel P., Grosha, Jonian, Zabroski, Ibukunoluwapo O., Banerjee, Sanchari, Gusenleitner, Daniel, Biette, Kelly M., Sedlak, Christopher R., Couvillon, Anthony D., Duff, Peter A., Byrne, Delaney M., King, MacKenzie Sadie, Jamieson, Amy, Winn-Deen, Emily S., McAlpine, Jessica N., Huntsman, David, Skates, Steven, Huang, Eric K., Sedlak, Joseph Charles

“…5542 Background: Detection of cancer with improved discrimination compared to current blood tests could be achieved using an approach that assesses…”
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Improving Specificity for Ovarian Cancer Screening Using a Novel Extracellular Vesicle–Based Blood Test by Winn-Deen, Emily S., Bortolin, Laura T., Gusenleitner, Daniel, Biette, Kelly M., Copeland, Karen, Gentry-Maharaj, Aleksandra, Apostolidou, Sophia, Couvillon, Anthony D., Salem, Daniel P., Banerjee, Sanchari, Grosha, Jonian, Zabroski, Ibukunoluwapo O., Sedlak, Christopher R., Byrne, Delaney M., Hamzeh, Bilal F., King, MacKenzie S., Cuoco, Lauren T., Duff, Peter A., Manning, Brendan J., Hawkins, Troy B., Mattoon, Dawn, Guettouche, Toumy, Skates, Steven J., Jamieson, Amy, McAlpine, Jessica N., Huntsman, David, Menon, Usha

“…The low incidence of ovarian cancer (OC) dictates that any screening strategy needs to be both highly sensitive and highly specific. This study explored the…”
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Genetic variability in CRHR1 and its association with participant response to glucocorticoid receptor‐mediated signaling (776.2) by Knox, Rachel, Biette, Kelly, Fox, Olivia, Murphy, Patrick

“…The goal of this study was to identify correlations between interpersonal genetic variability and alterations in the intracellular glucocorticoid receptor…”
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Effect of first-line spartalizumab + dabrafenib + trametinib on immunosuppressive features detected in peripheral blood and clinical outcome in patients (pts) with advanced BRAF V600–mutant melanoma by Dummer, Reinhard, Biette, Kelly, Gusenleitner, Daniel, Ramesh, Radha, Lebbe, Celeste, Atkinson, Victoria, Mandalà, Mario, Nathan, Paul D., Arance, Ana, Richtig, Erika, Yamazaki, Naoya, Robert, Caroline, Schadendorf, Dirk, Tawbi, Hussein Abdul-Hassan, Ascierto, Paolo Antonio, Ribas, Antoni, Flaherty, Keith, Gasal, Eduard, Brase, Jan C., Long, Georgina V.

“…Abstract only 10034 Background: Spartalizumab + dabrafenib + trametinib has previously shown a high response rate of 78% (28 of 36 pts), with a complete…”
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Hsp90 chaperone machinery coexpression increases functional glucocorticoid receptor protein expression, receptor•hsp90 heterocomplex formation, and steroid binding activity by Biette, Kelly M., Belyaev, Alexander S., Murphy, Patrick J. M.

“…Abstract only While hsp90 client proteins such as the glucocorticoid receptor (GR) are highly expressed using a baculovirus expression system, the majority of…”
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Abstract 7133: Phenomics-enabled discovery and optimization of small-molecule RBM39 degraders as an alternative to CDK12 targeting in high-grade serous ovarian cancer (HGSOC) by Neumann, Chase, Shankaran, Harish, Nadella, Kiran, Biette, Kelly, Rowley, Shane, Gardner, Ethan, Swaidani, Shadi, Manda, Vamshi, Chen, Lu, Beshnova, Daria, Saeed, Ashraf, Bailey, Christopher, Paulsen, Janet, Rearden, Paul, Brooks, Carl, Bhandari, Ashish, Gibson, Chris, Schaevitz, Laura, Haque, Imran, Donnella, Hayley, Cuccarese, Michael, Evangelista, Marie

“…Abstract Phenomics-enabled drug discovery is a powerful approach to identify novel targets and relationships previously unappreciated in biology. We built a…”
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Abstract 1066: Colocalization of ovarian cancer-associated biomarkers in tumors, cancer cells and extracellular vesicles by Couvillon, Anthony D., Winn-Deen, Emily S., Thornton, Shelby, Liu, Shuhong, DeRan, Michael, Pacula, Maciej, Banerjee, Sanchari, Gusenleitner, Daniel, Bortolin, Laura T., Grosha, Jonian, Santos-Heiman, Timothy, Sangiuliano, Gabrielle, Biette, Kelly M., Sedlak, Christopher R., Hamzeh, Bilal, Byrne, Delaney M., Duff, Peter A., Ho, Julie, Gao, Dongxia, Jamieson, Amy, Cuoco, Lauren T., King, MacKenzie S., Mattoon, Dawn R., Guettouche, Toumy, McAlpine, Jessica N., Huntsman, David

“…Abstract Introduction: We have previously shown that ovarian cancer can be detected with high specificity and sensitivity by interrogating colocalized…”
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Enhancer Interactions in Developmental Gene Regulation by Biette, Kelly Marie

“…When and where a gene is expressed during development is a critical determinant of cell identity and transcriptional mis-regulation is a common driver of…”
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Abstract A040: Improving specificity for ovarian cancer screening using a novel extracellular vesicle-based blood test by Winn-Deen, Emily S., Banerjee, Sanchari, Gusenleitner, Daniel, Bortolin, Laura T., Grosha, Jonian, Biette, Kelly M., Copeland, Karen, Sedlak, Christopher R., Hamzeh, Bilal, Couvillon, Anthony D., Byrne, Delaney M., Duff, Peter A., Cuoco, Lauren T., King, MacKenzie S., Gentry-Maharaj, Aleksandra, Apostolidou, Sophia, Mattoon, Dawn R., Berg, Christine D., Ransohoff, David F., Skates, Steven J., Menon, Usha

“…Abstract Introduction: The low incidence of ovarian cancer (OC) in average risk individuals dictates any OC screening method needs to be both highly sensitive…”
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