Search Results - "Bierut, L. J."

Smoking cessation is associated with lower rates of mood/anxiety and alcohol use disorders by Cavazos-Rehg, P A, Breslau, N, Hatsukami, D, Krauss, M J, Spitznagel, E L, Grucza, R A, Salyer, P, Hartz, S M, Bierut, L J

“…The psychological outcomes that accompany smoking cessation are not yet conclusive but positive outcomes could help to persuade quitting. We used data from the…”
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ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry by Bierut, L J, Goate, A M, Breslau, N, Johnson, E O, Bertelsen, S, Fox, L, Agrawal, A, Bucholz, K K, Grucza, R, Hesselbrock, V, Kramer, J, Kuperman, S, Nurnberger, J, Porjesz, B, Saccone, N L, Schuckit, M, Tischfield, J, Wang, J C, Foroud, T, Rice, J P, Edenberg, H J

“…A coding variant in alcohol dehydrogenase 1B ( ADH1B ) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces…”
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Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence by Wang, J C, Grucza, R, Cruchaga, C, Hinrichs, A L, Bertelsen, S, Budde, J P, Fox, L, Goldstein, E, Reyes, O, Saccone, N, Saccone, S, Xuei, X, Bucholz, K, Kuperman, S, Nurnberger, J, Rice, J P, Schuckit, M, Tischfield, J, Hesselbrock, V, Porjesz, B, Edenberg, H J, Bierut, L J, Goate, A M

“…Alcohol dependence frequently co-occurs with cigarette smoking, another common addictive behavior. Evidence from genetic studies demonstrates that alcohol…”
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A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53 by Wang, J-C, Foroud, T, Hinrichs, A L, Le, N X H, Bertelsen, S, Budde, J P, Harari, O, Koller, D L, Wetherill, L, Agrawal, A, Almasy, L, Brooks, A I, Bucholz, K, Dick, D, Hesselbrock, V, Johnson, E O, Kang, S, Kapoor, M, Kramer, J, Kuperman, S, Madden, P A F, Manz, N, Martin, N G, McClintick, J N, Montgomery, G W, Nurnberger, J I, Rangaswamy, M, Rice, J, Schuckit, M, Tischfield, J A, Whitfield, J B, Xuei, X, Porjesz, B, Heath, A C, Edenberg, H J, Bierut, L J, Goate, A M

“…Several studies have identified genes associated with alcohol-use disorders (AUDs), but the variation in each of these genes explains only a small portion of…”
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Meta-analysis of genome-wide association studies for personality by de Moor, M H M, Costa, P T, Terracciano, A, Krueger, R F, de Geus, E J C, Toshiko, T, Penninx, B W J H, Esko, T, Madden, P A F, Derringer, J, Amin, N, Willemsen, G, Hottenga, J-J, Distel, M A, Uda, M, Sanna, S, Spinhoven, P, Hartman, C A, Sullivan, P, Realo, A, Allik, J, Heath, A C, Pergadia, M L, Agrawal, A, Lin, P, Grucza, R, Nutile, T, Ciullo, M, Rujescu, D, Giegling, I, Konte, B, Widen, E, Cousminer, D L, Eriksson, J G, Palotie, A, Peltonen, L, Luciano, M, Tenesa, A, Davies, G, Lopez, L M, Hansell, N K, Medland, S E, Ferrucci, L, Schlessinger, D, Montgomery, G W, Wright, M J, Aulchenko, Y S, Janssens, A C J W, Oostra, B A, Metspalu, A, Abecasis, G R, Deary, I J, Räikkönen, K, Bierut, L J, Martin, N G, van Duijn, C M, Boomsma, D I

“…Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in…”
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Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men by Heath, A C, Bucholz, K K, Madden, P A, Dinwiddie, S H, Slutske, W S, Bierut, L J, Statham, D J, Dunne, M P, Whitfield, J B, Martin, N G

“…Genetic influences on alcoholism risk are well-documented in men, but uncertain in women. We tested for gender differences in genetic influences on, and…”
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Early sexual abuse and lifetime psychopathology: a co-twin-control study by Dinwiddie, S, Heath, A C, Dunne, M P, Bucholz, K K, Madden, P A, Slutske, W S, Bierut, L J, Statham, D B, Martin, N G

“…This study was designed to determine lifetime prevalence of psychiatric disorders among twins who reported childhood sexual abuse (CSA), and to compare these…”
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Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk by Heath, A C, Madden, P A, Bucholz, K K, Dinwiddie, S H, Slutske, W S, Bierut, L J, Rohrbaugh, J W, Statham, D J, Dunne, M P, Whitfield, J B, Martin, N G

“…Substantial evidence exists for an important genetic contribution to alcohol dependence risk in women and men. It has been suggested that genetically…”
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Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability by Duncan, L E, Ratanatharathorn, A, Aiello, A E, Almli, L M, Amstadter, A B, Ashley-Koch, A E, Baker, D G, Beckham, J C, Bierut, L J, Bisson, J, Bradley, B, Chen, C-Y, Dalvie, S, Farrer, L A, Galea, S, Garrett, M E, Gelernter, J E, Guffanti, G, Hauser, M A, Johnson, E O, Kessler, R C, Kimbrel, N A, King, A, Koen, N, Kranzler, H R, Logue, M W, Maihofer, A X, Martin, A R, Miller, M W, Morey, R A, Nugent, N R, Rice, J P, Ripke, S, Roberts, A L, Saccone, N L, Smoller, J W, Stein, D J, Stein, M B, Sumner, J A, Uddin, M, Ursano, R J, Wildman, D E, Yehuda, R, Zhao, H, Daly, M J, Liberzon, I, Ressler, K J, Nievergelt, C M, Koenen, K C

“…The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case–control molecular genetic data across 11…”
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Common biological networks underlie genetic risk for alcoholism in African‐ and European‐American populations by Kos, M. Z., Yan, J., Dick, D. M., Agrawal, A., Bucholz, K. K., Rice, J. P., Johnson, E. O., Schuckit, M., Kuperman, S., Kramer, J., Goate, A. M., Tischfield, J. A., Foroud, T., Nurnberger, J., Hesselbrock, V., Porjesz, B., Bierut, L. J., Edenberg, H. J., Almasy, L.

“…Alcohol dependence (AD) is a heritable substance addiction with adverse physical and psychological consequences, representing a major health and economic…”
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Declines in prevalence of adolescent substance use disorders and delinquent behaviors in the USA: a unitary trend? by Grucza, R A, Krueger, R F, Agrawal, Arpana, Plunk, A D, Krauss, M J, Bongu, J, Cavazos-Rehg, P A, Bierut, L J

“…Downward trends in a number of adolescent risk behaviors including violence, crime, and drug use have been observed in the USA in recent years. It is unknown…”
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The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data by Middeldorp, C M, de Moor, M H M, McGrath, L M, Gordon, S D, Blackwood, D H, Costa, P T, Terracciano, A, Krueger, R F, de Geus, E J C, Nyholt, D R, Tanaka, T, Esko, T, Madden, P A F, Derringer, J, Amin, N, Willemsen, G, Hottenga, J-J, Distel, M A, Uda, M, Sanna, S, Spinhoven, P, Hartman, C A, Ripke, S, Sullivan, P F, Realo, A, Allik, J, Heath, A C, Pergadia, M L, Agrawal, A, Lin, P, Grucza, R A, Widen, E, Cousminer, D L, Eriksson, J G, Palotie, A, Barnett, J H, Lee, P H, Luciano, M, Tenesa, A, Davies, G, Lopez, L M, Hansell, N K, Medland, S E, Ferrucci, L, Schlessinger, D, Montgomery, G W, Wright, M J, Aulchenko, Y S, Janssens, A C J W, Oostra, B A, Metspalu, A, Abecasis, G R, Deary, I J, Räikkönen, K, Bierut, L J, Martin, N G, Wray, N R, van Duijn, C M, Smoller, J W, Penninx, B W J H, Boomsma, D I

“…The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and…”
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Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence by Hancock, D B, Guo, Y, Reginsson, G W, Gaddis, N C, Lutz, S M, Sherva, R, Loukola, A, Minica, C C, Markunas, C A, Han, Y, Young, K A, Gudbjartsson, D F, Gu, F, McNeil, D W, Qaiser, B, Glasheen, C, Olson, S, Landi, M T, Madden, P A F, Farrer, L A, Vink, J, Saccone, N L, Neale, M C, Kranzler, H R, McKay, J, Hung, R J, Amos, C I, Marazita, M L, Boomsma, D I, Baker, T B, Gelernter, J, Kaprio, J, Caporaso, N E, Thorgeirsson, T E, Hokanson, J E, Bierut, L J, Stefansson, K, Johnson, E O

“…Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable…”
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Evidence of CNIH3 involvement in opioid dependence by Nelson, E C, Agrawal, A, Heath, A C, Bogdan, R, Sherva, R, Zhang, B, Al-Hasani, R, Bruchas, M R, Chou, Y-L, Demers, C H, Carey, C E, Conley, E D, Fakira, A K, Farrer, L A, Goate, A, Gordon, S, Henders, A K, Hesselbrock, V, Kapoor, M, Lynskey, M T, Madden, P A F, Moron, J A, Rice, J P, Saccone, N L, Schwab, S G, Shand, F L, Todorov, A A, Wallace, L, Wang, T, Wray, N R, Zhou, X, Degenhardt, L, Martin, N G, Hariri, A R, Kranzler, H R, Gelernter, J, Bierut, L J, Clark, D J, Montgomery, G W

“…Opioid dependence, a severe addictive disorder and major societal problem, has been demonstrated to be moderately heritable. We conducted a genome-wide…”
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Latent class and factor analysis of DSM-IV ADHD: a twin study of female adolescents by Hudziak, J J, Heath, A C, Madden, P F, Reich, W, Bucholz, K K, Slutske, W, Bierut, L J, Neuman, R J, Todd, R D

“…In an attempt to validate the current DSM-IV criteria for attention-deficit/hyperactivity disorder (ADHD) in females and to determine whether symptoms are…”
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Genome-wide association study identifies a novel locus for cannabis dependence by Agrawal, A, Chou, Y-L, Carey, C E, Baranger, D A A, Zhang, B, Sherva, R, Wetherill, L, Kapoor, M, Wang, J-C, Bertelsen, S, Anokhin, A P, Hesselbrock, V, Kramer, J, Lynskey, M T, Meyers, J L, Nurnberger, J I, Rice, J P, Tischfield, J, Bierut, L J, Degenhardt, L, Farrer, L A, Gelernter, J, Hariri, A R, Heath, A C, Kranzler, H R, Madden, P A F, Martin, N G, Montgomery, G W, Porjesz, B, Wang, T, Whitfield, J B, Edenberg, H J, Foroud, T, Goate, A M, Bogdan, R, Nelson, E C

“…Despite moderate heritability, only one study has identified genome-wide significant loci for cannabis-related phenotypes. We conducted meta-analyses of…”
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Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence by Hancock, D B, Reginsson, G W, Gaddis, N C, Chen, X, Saccone, N L, Lutz, S M, Qaiser, B, Sherva, R, Steinberg, S, Zink, F, Stacey, S N, Glasheen, C, Chen, J, Gu, F, Frederiksen, B N, Loukola, A, Gudbjartsson, D F, Brüske, I, Landi, M T, Bickeböller, H, Madden, P, Farrer, L, Kaprio, J, Kranzler, H R, Gelernter, J, Baker, T B, Kraft, P, Amos, C I, Caporaso, N E, Hokanson, J E, Bierut, L J, Thorgeirsson, T E, Johnson, E O, Stefansson, K

“…We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerström Test for Nicotine…”
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Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain by Teitelbaum, A M, Murphy, S E, Akk, G, Baker, T B, Germann, A, von Weymarn, L B, Bierut, L J, Goate, A, Kharasch, E D, Bloom, A J

“…A common haplotype of the flavin-containing monooxygenase gene FMO3 is associated with aberrant mRNA splicing, a twofold reduction in in vivo nicotine…”
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Towards a molecular epidemiology of alcohol dependence: Analysing the interplay of genetic and environmental risk factors by Heath, A. C., Madden, P. A. F., Bucholz, K. K., Bierut, L. J., Whitfield, J. B., Dinwiddie, S. H., Slutske, W. S., Statham, D. B., Martin, Nicholas G.

“…Progress in identifying genetic factors protective against alcohol dependence (AlcD) requires a paradigm shift in psychiatric epidemiology. To integrate…”
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Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans by Saccone, N. L., Schwantes‐An, T.‐H., Wang, J. C., Grucza, R. A., Breslau, N., Hatsukami, D., Johnson, E. O., Rice, J. P., Goate, A. M., Bierut, L. J.

“…Several independent studies show that the chromosome 15q25.1 region, which contains the CHRNA5–CHRNA3–CHRNB4 gene cluster, harbors variants strongly associated…”
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