Search Results - "Bierle, Craig J."

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits by Cheng, Adam Z, Moraes, Sofia N, Attarian, Claire, Yockteng-Melgar, Jaime, Jarvis, Matthew C, Biolatti, Matteo, Galitska, Ganna, Dell'Oste, Valentina, Frappier, Lori, Bierle, Craig J, Rice, Stephen A, Harris, Reuben S

“…An integral part of the antiviral innate immune response is the APOBEC3 family of single-stranded DNA cytosine deaminases, which inhibits virus replication…”
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CD4+ but not CD8+ T cells are required for protection against severe guinea pig cytomegalovirus infections by Rollman, Tyler B., Berkebile, Zachary W., Hicks, Dustin M., Hatfield, Jason S., Chauhan, Priyanka, Pravetoni, Marco, Schleiss, Mark R., Milligan, Gregg N., Morgan, Terry K., Bierle, Craig J.

“…Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus and the leading cause of infectious disease related birth defects worldwide. How the immune response…”
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APOBECs and Herpesviruses by Cheng, Adam Z, Moraes, Sofia N, Shaban, Nadine M, Fanunza, Elisa, Bierle, Craig J, Southern, Peter J, Bresnahan, Wade A, Rice, Stephen A, Harris, Reuben S

“…The APOBEC family of DNA cytosine deaminases provides a broad and overlapping defense against viral infections. Successful viral pathogens, by definition, have…”
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Droplet Digital PCR (ddPCR) Does Not Enhance the Sensitivity of Detection of Cytomegalovirus (CMV) DNA in Newborn Dried Blood Spots Evaluated in the Context of Newborn Congenital CMV (cCMV) Screening by Hernandez-Alvarado, Nelmary, Bierle, Craig J, Schleiss, Mark R

“…Congenital cytomegalovirus (cCMV) infection is a leading cause of sensorineural hearing loss (SNHL) and neurodevelopmental disabilities in children worldwide…”
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Assessing Zika virus replication and the development of Zika-specific antibodies after a mid-gestation viral challenge in guinea pigs by Bierle, Craig J, Fernández-Alarcón, Claudia, Hernandez-Alvarado, Nelmary, Zabeli, Jason C, Janus, Bradley C, Putri, Dira S, Schleiss, Mark R

“…Primary Zika virus (ZIKV) infections that occur during pregnancy can cause spontaneous abortion and profoundly disrupt fetal development. While the full range…”
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Essential Role for either TRS1 or IRS1 in Human Cytomegalovirus Replication by MARSHALL, Emily E, BIERLE, Craig J, BRUNE, Wolfram, GEBALLE, Adam P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Zika virus-based immunotherapy enhances long-term survival of rodents with brain tumors through upregulation of memory T-cells by Crane, Andrew T, Chrostek, Matthew R, Krishna, Venkatramana D, Shiao, Maple, Toman, Nikolas G, Pearce, Clairice M, Tran, Sarah K, Sipe, Christopher J, Guo, Winston, Voth, Joseph P, Vaid, Shivanshi, Xie, Hui, Lu, Wei-Cheng, Swanson, Will, Grande, Andrew W, Schleiss, Mark R, Bierle, Craig J, Cheeran, Maxim C-J, Low, Walter C

“…Zika virus (ZIKV) exhibits a tropism for brain tumor cells and has been used as an oncolytic virus to target brain tumors in mice with modest effects on…”
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The Placental Response to Guinea Pig Cytomegalovirus Depends Upon the Timing of Maternal Infection by Berkebile, Zachary W, Putri, Dira S, Abrahante, Juan E, Seelig, Davis M, Schleiss, Mark R, Bierle, Craig J

“…Human cytomegalovirus (HCMV) infects the placenta, and these placental infections can cause fetal injury and/or demise. The timing of maternal HCMV infection…”
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Repair of a Mutation Disrupting the Guinea Pig Cytomegalovirus Pentameric Complex Acquired during Fibroblast Passage Restores Pathogenesis in Immune-Suppressed Guinea Pigs and in the Context of Congenital Infection by McVoy, Michael A, Wang, Jian Ben, Dittmer, Dirk P, Bierle, Craig J, Swanson, Elizabeth C, Fernández-Alarcón, Claudia, Hernandez-Alvarado, Nelmary, Zabeli, Jason C, Schleiss, Mark R

“…Guinea pig cytomegalovirus (GPCMV) provides a valuable model for congenital cytomegalovirus transmission. Salivary gland (SG)-passaged stocks of GPCMV are…”
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Group B streptococcal infection of the choriodecidua induces dysfunction of the cytokeratin network in amniotic epithelium: a pathway to membrane weakening by Vanderhoeven, Jeroen P, Bierle, Craig J, Kapur, Raj P, McAdams, Ryan M, Beyer, Richard P, Bammler, Theo K, Farin, Federico M, Bansal, Aasthaa, Spencer, Min, Deng, Mei, Gravett, Michael G, Rubens, Craig E, Rajagopal, Lakshmi, Adams Waldorf, Kristina M

“…Early events leading to intrauterine infection remain poorly defined, but may hold the key to preventing preterm delivery. To determine molecular pathways…”
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Antagonism of the protein kinase R pathway by the guinea pig cytomegalovirus US22-family gene gp145 by Bierle, Craig J, Schleiss, Mark R, Geballe, Adam P

“…Abstract Viral double-stranded RNA (dsRNA) activates protein kinase R (PKR), which phosphorylates eIF2α and inhibits translation. In response, viruses have…”
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Human trophoblast stem cells restrict human cytomegalovirus replication by Rollman, Tyler B, Berkebile, Zachary W, Okae, Hiroaki, Bardwell, Vivian J, Gearhart, Micah D, Bierle, Craig J

“…Placental infection plays a central role in the pathogenesis of congenital human cytomegalovirus (HCMV) infections and is a cause of fetal growth restriction…”
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Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism by Fanunza, Elisa, Cheng, Adam Z, Auerbach, Ashley A, Stefanovska, Bojana, Moraes, Sofia N, Lokensgard, James R, Biolatti, Matteo, Dell'Oste, Valentina, Bierle, Craig J, Bresnahan, Wade A, Harris, Reuben S

“…The APOBEC3 family of DNA cytosine deaminases comprises an important arm of the innate antiviral defense system. The gamma-herpesviruses Epstein-Barr virus and…”
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Targeted Mutagenesis of Guinea Pig Cytomegalovirus Using CRISPR/Cas9-Mediated Gene Editing by Bierle, Craig J, Anderholm, Kaitlyn M, Wang, Jian Ben, McVoy, Michael A, Schleiss, Mark R

“…The cytomegaloviruses (CMVs) are among the most genetically complex mammalian viruses, with viral genomes that often exceed 230 kbp. Manipulation of…”
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MicroRNA Signature of Epithelial-Mesenchymal Transition in Group B Streptococcal Infection of the Placental Chorioamniotic Membranes by Weed, Samantha, Armistead, Blair, Coleman, Michelle, Liggit, H Denny, Johnson, Brian, Tsai, Jesse, Beyer, Richard P, Bammler, Theodor K, Kretzer, Nicole M, Parker, Ed, Vanderhoeven, Jeroen P, Bierle, Craig J, Rajagopal, Lakshmi, Adams Waldorf, Kristina M

“…Abstract Background Infection-induced preterm birth is a major cause of neonatal mortality and morbidity and leads to preterm premature rupture of placental…”
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Vaccination with a Live Attenuated Cytomegalovirus Devoid of a Protein Kinase R Inhibitory Gene Results in Reduced Maternal Viremia and Improved Pregnancy Outcome in a Guinea Pig Congenital Infection Model by Schleiss, Mark R, Bierle, Craig J, Swanson, Elizabeth C, McVoy, Michael A, Wang, Jian Ben, Al-Mahdi, Zainab, Geballe, Adam P

“…Development of a vaccine to prevent congenital cytomegalovirus infection is a major public health priority. Live vaccines attenuated through mutations…”
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Cytomegalovirus infection elicits a conserved chemokine response from human and guinea pig amnion cells by Putri, Dira S., Berkebile, Zachary W., Mustafa, Hiba J., Fernández-Alarcón, Claudia, Abrahante, Juan E., Schleiss, Mark R., Bierle, Craig J.

“…Human cytomegalovirus (HCMV) infects the chorioamnion, but whether these infections cause fetal membrane dysfunction remains poorly understood. We sought to…”
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Choriodecidual Group B Streptococcal Infection Induces miR-155-5p in the Fetal Lung in Macaca nemestrina by McAdams, Ryan M, Bierle, Craig J, Boldenow, Erica, Weed, Samantha, Tsai, Jesse, Beyer, Richard P, MacDonald, James W, Bammler, Theo K, Liggitt, H Denny, Farin, Federico M, Vanderhoeven, Jeroen, Rajagopal, Lakshmi, Adams Waldorf, Kristina M

“…The mechanisms underlying fetal lung injury remain poorly defined. MicroRNAs (miRNAs) are small noncoding, endogenous RNAs that regulate gene expression and…”
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Double-stranded RNA binding by the human cytomegalovirus PKR antagonist TRS1 by Bierle, Craig J, Semmens, Kathryn M, Geballe, Adam P

“…Abstract Protein Kinase R (PKR) inhibits translation initiation following double-stranded RNA (dsRNA) binding and thereby represses viral replication. Human…”
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Droplet Digital PCR Screening by Hernandez-Alvarado, Nelmary, Bierle, Craig J, Schleiss, Mark R

“…Congenital cytomegalovirus (cCMV) infection is a leading cause of sensorineural hearing loss (SNHL) and neurodevelopmental disabilities in children worldwide…”
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