Search Results - "Bierau, J."

Visualization of anatomical structures in the carpal region of the horse using cone beam computed tomography in comparison with conventional multidetector computed tomography by Hagenbach, M., Bierau, J., Cruz, A. M., Koch, C., Manso-Díaz, G., Büttner, K., Staszyk, C., Röcken, M.

“…Introduction In the diagnostics of orthopedic diseases in the horse, diagnostic imaging often plays a decisive role. Cone beam computed tomography (CBCT)…”
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The unfolding clinical spectrum of POLG mutations by Blok, M J, van den Bosch, B J, Jongen, E, Hendrickx, A, de Die-Smulders, C E, Hoogendijk, J E, Brusse, E, de Visser, M, Poll-The, B T, Bierau, J, de Coo, I F, Smeets, H J

“…Mutations in the DNA polymerase-gamma (POLG) gene are a major cause of clinically heterogeneous mitochondrial diseases, associated with mtDNA depletion and…”
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A role for ITPA variants in the clinical course of pulmonary Langerhans' cell histiocytosis? by Bakker, J A, Bierau, J, Drent, M

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Evolution of Dihydropyrimidine Dehydrogenase (DPD) Diagnostics in A Single Center in A Time-Period of Seven Years by van den Bosch, B.J.C, Paulussen, A.D.C, Breuer, M, Lindhout, M, Tserpelis, D.C.J, Steyls, A, Bierau, J, Coenen, M.J.H

“…In this time-frame the test has evolved from a single enzyme measurement using ultra-high performance liquid chromatography (UHPLC) in peripheral blood…”
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The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients by GILISSEN, L. P. L., BIERAU, J., DERIJKS, L. J. J., BOS, L. P., HOOYMANS, P. M., GENNIP, A., STOCKBRÜGGER, R. W., ENGELS, L. G. J. B.

“…Summary Background : In vitro studies suggest interactions between mesalazine (mesalamine) and thiopurines by thiopurine S‐methyltransferase (TPMT) inhibition,…”
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Decreased oxidative phosphorylation and PGAM deficiency in horses suffering from atypical myopathy associated with acquired MADD by Westermann, C.M., Dorland, L., van Diggelen, O.P., Schoonderwoerd, K., Bierau, J., Waterham, H.R., van der Kolk, J.H.

“…Earlier research on ten horses suffering from the frequently fatal disorder atypical myopathy showed that MADD (multiple acyl-CoA dehydrogenase deficiency) is…”
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Therapeutic regimens in interstitial lung disease guided by genetic screening: fact or fiction? by Bakker, J A, Bierau, J, Drent, M

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Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease by Gilissen, L.P.L, Derijks, L.J.J, Verhoeven, H.M.J.H, Bierau, J, Hooymans, P.M, Hommes, D.W, Engels, L.G.J.B

“…Abstract In a 23-year-old female with colonic Crohn's disease 6-mercaptopurine 100 mg daily (1.7 mg/kg) was added to mesalamine and prednisolone therapy…”
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Determination of ITPase Activity in Erythrocyte Lysates Obtained for Determination of Tpmt Activity by Bierau, J., Bakker, J. A., Lindhout, M., van Gennip, A. H.

“…The indication for the determination of both thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase is identical (i.e., adverse drug…”
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Biochemical Monitoring and Management During Pregnancy in Patients with Isovaleric Acidaemia is Helpful to Prevent Metabolic Decompensation by Habets, D. D. J., Schaper, N. C., Rogozinski, H., van Spronsen, F. J., van Rijn, M., Bierau, J., Bakker, J. A.

“…The facilities for neonatal screening, early diagnosis, and effective treatment of isovaleric acidaemia (IVA) have improved greatly over the past decades…”
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Dihydropyrimidine Dehydrogenase Deficiency Caused by a Novel Genomic Deletion c.505_513del of DPYD by van Kuilenburg, A. B. P., Meijer, J., Gökcay, G., Baykal, T., Rubio-Gozalbo, M. E., Mul, A. N. P. M., de Die-Smulders, C. E. M., Weber, P., Mori, A. Capone, Bierau, J., Fowler, B., Macke, K., Sass, J. O., Meinsma, R., Hennermann, J. B., Miny, P., Zoetekouw, L., Roelofsen, J., Vijzelaar, R., Nicolai, J., Hennekam, R. C. M.

“…Dihydropyrimidine dehydrogenase (DPD) deficiency is an autosomal recessive disorder of the pyrimidine degradation pathway. In a patient presenting with…”
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Allogeneic haematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalomyopathy by Halter, Joerg P, Michael, W, Schüpbach, M, Mandel, Hanna, Casali, Carlo, Orchard, Kim, Collin, Matthew, Valcarcel, David, Rovelli, Attilio, Filosto, Massimiliano, Dotti, Maria T, Marotta, Giuseppe, Pintos, Guillem, Barba, Pere, Accarino, Anna, Ferra, Christelle, Illa, Isabel, Beguin, Yves, Bakker, Jaap A, Boelens, Jaap J, de Coo, Irenaeus F M, Fay, Keith, Sue, Carolyn M, Nachbaur, David, Zoller, Heinz, Sobreira, Claudia, Pinto Simoes, Belinda, Hammans, Simon R, Savage, David, Martí, Ramon, Chinnery, Patrick F, Elhasid, Ronit, Gratwohl, Alois, Hirano, Michio

“…Haematopoietic stem cell transplantation has been proposed as treatment for mitochondrial neurogastrointestinal encephalomyopathy, a rare fatal autosomal…”
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Recovery of SK-N-BE(2)c cells from treatment with cyclopentenyl cytosine by Bierau, J, van Gennip, A H, van Kuilenburg, A B

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Metabolic inactivation of five glycidyl ethers in lung and liver of humans, rats and mice in vitro by Boogaard, P. J., De Kloe, K. P., Bierau, J., Kuiken, G., Borkulo, P. E. D., Van Sittert, N. J.

“…1. Some glycidyl ethers (GE) have been shown to be direct mutagens in short-term in vitro tests and consequently GE are considered to be potentially mutagenic…”
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LOW-GRADE RENAL ARTERY STENOSIS AND THE RENAL HANDLING OF THE NITRIC OXIDE SYNTHASE INHIBITOR ASYMMETRIC DIMETHYLARGININE (ADMA): 7B.04 by Ronden, R., Houben, A., Bakker, J., Bierau, J., Stehouwer, C., De Leeuw, P., Kroon, A.

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SHORT-TERM EFFECTS OF INTRARENAL EPROSARTAN INFUSION ON THE RENAL HANDLING OF ASYMMETRIC DIMETHYLARGININE (ADMA): 7B.07 by Ronden, R., Houben, A., Tazelaar, C., Bakker, J., Bierau, J., Stehouwer, C., Leeuw, P. D.E., Kroon, A.

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Azathioprine and diffuse alveolar haemorrhage: the pharmacogenetics of thiopurine methyltransferase by Perri, D, Cole, D. E. C, Friedman, O, Piliotis, E, Mintz, S, Adhikari, N. K. J

“…Current guidelines support the use of corticosteroids and azathioprine as one possible treatment strategy for idiopathic pulmonary fibrosis (IPF). However,…”
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Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma by BIERAU, Jörgen, VAN GENNIP, Albert H, LEEN, René, MEINSMA, Rutger, CARON, Huib N, VAN KUILENBURG, André B. P

“…The effect of the CTP synthetase inhibitor cyclopentenyl cytosine (CPEC) on the metabolism and cytotoxicity of 2',2'-difluorodeoxycytidine (dFdC, gemcitabine)…”
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Cyclopentenyl cytosine primes SK‐N‐BE(2)c neuroblastoma cells for cytarabine toxicity by Bierau, Jörgen, van Gennip, Albert H., Leen, René, Helleman, Jozien, Caron, Huib N., van Kuilenburg, André B.P.

“…CPEC is a potent inhibitor of CTP synthetase and causes depletion of CTP and dCTP pools. AraC is an analog of dCyd and a chemotherapeutic agent. Here, we…”
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The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on neuroblastoma cell lines by Bierau, Jörgen, van Gennip, Albert H., Helleman, Jozien, van Kuilenburg, André B.P.

“…This paper describes the effects of cyclopentenyl cytosine (CPEC) on the proliferation and cell-cycle distribution of the SK-N-BE(2)c and SK-N-SH neuroblastoma…”
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