Search Results - "Bieniasz, Paul D."

Plasma Neutralization of the SARS-CoV-2 Omicron Variant by Schmidt, Fabian, Muecksch, Frauke, Weisblum, Yiska, Da Silva, Justin, Bednarski, Eva, Cho, Alice, Wang, Zijun, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over…”
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Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses by Schmidt, Fabian, Weisblum, Yiska, Muecksch, Frauke, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Lorenzi, Julio C C, Mendoza, Pilar, Rutkowska, Magdalena, Bednarski, Eva, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Caskey, Marina, Robbiani, Davide F, Nussenzweig, Michel C, Rice, Charles M, Hatziioannou, Theodora, Bieniasz, Paul D

“…The emergence of SARS-CoV-2 and the ensuing explosive epidemic of COVID-19 disease has generated a need for assays to rapidly and conveniently measure the…”
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Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients by Muecksch, Frauke, Wise, Helen, Batchelor, Becky, Squires, Maria, Semple, Elizabeth, Richardson, Claire, McGuire, Jacqueline, Clearly, Sarah, Furrie, Elizabeth, Greig, Neil, Hay, Gordon, Templeton, Kate, Lorenzi, Julio C C, Hatziioannou, Theodora, Jenks, Sara, Bieniasz, Paul D

“…Abstract Background Understanding the longitudinal trajectory of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is crucial for…”
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High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape by Schmidt, Fabian, Weisblum, Yiska, Rutkowska, Magdalena, Poston, Daniel, DaSilva, Justin, Zhang, Fengwen, Bednarski, Eva, Cho, Alice, Schaefer-Babajew, Dennis J., Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Hatziioannou, Theodora, Bieniasz, Paul D.

“…The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in individuals who are SARS-CoV-2 convalescent and vaccinated are key…”
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Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection by Wang, Zijun, Muecksch, Frauke, Schaefer-Babajew, Dennis, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Hoffmann, Hans- Heinrich, Barnes, Christopher O., Cipolla, Melissa, Ramos, Victor, Oliveira, Thiago Y., Cho, Alice, Schmidt, Fabian, Da Silva, Justin, Bednarski, Eva, Aguado, Lauren, Yee, Jim, Daga, Mridushi, Turroja, Martina, Millard, Katrina G., Jankovic, Mila, Gazumyan, Anna, Zhao, Zhen, Rice, Charles M., Bieniasz, Paul D., Caskey, Marina, Hatziioannou, Theodora, Nussenzweig, Michel C.

“…More than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Mechanism of HIV-1 virion entrapment by tetherin by Venkatesh, Siddarth, Bieniasz, Paul D

“…Tetherin, an interferon-inducible membrane protein, inhibits the release of nascent enveloped viral particles from the surface of infected cells. However, the…”
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HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137 by Zhang, Fengwen, Bieniasz, Paul D

“…The HIV-1 Vpr accessory protein induces ubiquitin/proteasome-dependent degradation of many cellular proteins by recruiting them to a cullin4A-DDB1-DCAF1…”
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Intrinsic Cellular Defenses against Human Immunodeficiency Viruses by Blanco-Melo, Daniel, Venkatesh, Siddarth, Bieniasz, Paul D.

“…Viral infections are often detrimental to host survival and reproduction. Consequently, hosts have evolved a variety of mechanisms to defend themselves against…”
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Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies by Greaney, Allison J., Starr, Tyler N., Barnes, Christopher O., Weisblum, Yiska, Schmidt, Fabian, Caskey, Marina, Gaebler, Christian, Cho, Alice, Agudelo, Marianna, Finkin, Shlomo, Wang, Zijun, Poston, Daniel, Muecksch, Frauke, Hatziioannou, Theodora, Bieniasz, Paul D., Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J., Bloom, Jesse D.

“…Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions…”
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Enhanced SARS-CoV-2 neutralization by dimeric IgA by Wang, Zijun, Lorenzi, Julio C C, Muecksch, Frauke, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Cipolla, Melissa, Hoffmann, Hans-Heinrich, Oliveira, Thiago Y, Oren, Deena A, Ramos, Victor, Nogueira, Lilian, Michailidis, Eleftherios, Robbiani, Davide F, Gazumyan, Anna, Rice, Charles M, Hatziioannou, Theodora, Bieniasz, Paul D, Caskey, Marina, Nussenzweig, Michel C

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), primarily infects cells at mucosal…”
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Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants by Weisblum, Yiska, Schmidt, Fabian, Zhang, Fengwen, DaSilva, Justin, Poston, Daniel, Lorenzi, Julio Cc, Muecksch, Frauke, Rutkowska, Magdalena, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Luchsinger, Larry, Hillyer, Christopher D, Caskey, Marina, Robbiani, Davide F, Rice, Charles M, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against…”
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Global Changes in the RNA Binding Specificity of HIV-1 Gag Regulate Virion Genesis by Kutluay, Sebla B., Zang, Trinity, Blanco-Melo, Daniel, Powell, Chelsea, Jannain, David, Errando, Manel, Bieniasz, Paul D.

“…The HIV-1 Gag protein orchestrates all steps of virion genesis, including membrane targeting and RNA recruitment into virions. Using…”
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Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost by Muecksch, Frauke, Wang, Zijun, Cho, Alice, Gaebler, Christian, Ben Tanfous, Tarek, DaSilva, Justin, Bednarski, Eva, Ramos, Victor, Zong, Shuai, Johnson, Brianna, Raspe, Raphael, Schaefer-Babajew, Dennis, Shimeliovich, Irina, Daga, Mridushi, Yao, Kai-Hui, Schmidt, Fabian, Millard, Katrina G., Turroja, Martina, Jankovic, Mila, Oliveira, Thiago Y., Gazumyan, Anna, Caskey, Marina, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.

“…The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals 1 – 3 . Despite the reduced protection from infection, individuals who…”
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Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination by Cho, Alice, Muecksch, Frauke, Schaefer-Babajew, Dennis, Wang, Zijun, Finkin, Shlomo, Gaebler, Christian, Ramos, Victor, Cipolla, Melissa, Mendoza, Pilar, Agudelo, Marianna, Bednarski, Eva, DaSilva, Justin, Shimeliovich, Irina, Dizon, Juan, Daga, Mridushi, Millard, Katrina G., Turroja, Martina, Schmidt, Fabian, Zhang, Fengwen, Tanfous, Tarek Ben, Jankovic, Mila, Oliveria, Thiago Y., Gazumyan, Anna, Caskey, Marina, Bieniasz, Paul D., Hatziioannou, Theodora, Nussenzweig, Michel C.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell responses that continue to evolve for at least a year. During that time,…”
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Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo by Schäfer, Alexandra, Muecksch, Frauke, Lorenzi, Julio C C, Leist, Sarah R, Cipolla, Melissa, Bournazos, Stylianos, Schmidt, Fabian, Maison, Rachel M, Gazumyan, Anna, Martinez, David R, Baric, Ralph S, Robbiani, Davide F, Hatziioannou, Theodora, Ravetch, Jeffrey V, Bieniasz, Paul D, Bowen, Richard A, Nussenzweig, Michel C, Sheahan, Timothy P

“…SARS-CoV-2, the causative agent of COVID-19, has been responsible for over 42 million infections and 1 million deaths since its emergence in December 2019…”
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Analysis of the initiating events in HIV-1 particle assembly and genome packaging by Kutluay, Sebla B, Bieniasz, Paul D

“…HIV-1 Gag drives a number of events during the genesis of virions and is the only viral protein required for the assembly of virus-like particles in vitro and…”
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Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu by Bieniasz, Paul D, Neil, Stuart J. D, Zang, Trinity

“…Human cells possess an antiviral activity that inhibits the release of retrovirus particles, and other enveloped virus particles, and is antagonized by the…”
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Identification of Interferon-Stimulated Genes with Antiretroviral Activity by Kane, Melissa, Zang, Trinity M., Rihn, Suzannah J., Zhang, Fengwen, Kueck, Tonya, Alim, Mudathir, Schoggins, John, Rice, Charles M., Wilson, Sam J., Bieniasz, Paul D.

“…Interferons (IFNs) exert their anti-viral effects by inducing the expression of hundreds of IFN-stimulated genes (ISGs). The activity of known ISGs is…”
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MX2 is an interferon-induced inhibitor of HIV-1 infection by Kane, Melissa, Yadav, Shalini S., Bitzegeio, Julia, Kutluay, Sebla B., Zang, Trinity, Wilson, Sam J., Schoggins, John W., Rice, Charles M., Yamashita, Masahiro, Hatziioannou, Theodora, Bieniasz, Paul D.

“…MX2 is shown to be an interferon-induced inhibitor of HIV-1 infection, and this antiviral activity may involve the inhibition of nuclear import of subviral…”
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Molecular fate-mapping of serum antibody responses to repeat immunization by Schiepers, Ariën, van ’t Wout, Marije F. L., Greaney, Allison J., Zang, Trinity, Muramatsu, Hiromi, Lin, Paulo J. C., Tam, Ying K., Mesin, Luka, Starr, Tyler N., Bieniasz, Paul D., Pardi, Norbert, Bloom, Jesse D., Victora, Gabriel D.

“…The protective efficacy of serum antibodies results from the interplay of antigen-specific B cell clones of different affinities and specificities. These…”
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