Search Results - "Biella, Gerardo Rosario"
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026 Vasoactive Intestinal Polypeptide Directly Excites Neurons of the Subparaventricular Zone
Published in Sleep (New York, N.Y.) (03-05-2021)“…Abstract Introduction The suprachiasmatic nucleus (SCN) is responsible for generating the circadian rhythmicity in mammals. The ventral region or core of the…”
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Novel multitarget directed ligands inspired by riluzole: A serendipitous synthesis of substituted benzo[b][1,4]thiazepines potentially useful as neuroprotective agents
Published in Bioorganic & medicinal chemistry (01-10-2024)“…[Display omitted] •Synthesis of novel MTDLs homodimers inspired by riluzole 2a-c was planned.•Compounds 3a-c and expanded intermediates 4a-c were…”
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Lysosomal TRPML1 triggers global Ca2+ signals and nitric oxide release in human cerebrovascular endothelial cells
Published in Frontiers in physiology (21-06-2024)“…Lysosomal Ca 2+ signaling is emerging as a crucial regulator of endothelial Ca 2+ dynamics. Ca 2+ release from the acidic vesicles in response to extracellular…”
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Oxytocin Modifies the Excitability and the Action Potential Shape of the Hippocampal CA1 GABAergic Interneurons
Published in International journal of molecular sciences (23-02-2024)“…Oxytocin (OT) is a neuropeptide that modulates social-related behavior and cognition in the central nervous system of mammals. In the CA1 area of the…”
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Neuromodulatory functions exerted by oxytocin on different populations of hippocampal neurons in rodents
Published in Frontiers in cellular neuroscience (02-02-2023)“…Oxytocin (OT) is a neuropeptide widely known for its peripheral hormonal effects (i.e., parturition and lactation) and central neuromodulatory functions,…”
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Membrane Resonance in Pyramidal and GABAergic Neurons of the Mouse Perirhinal Cortex
Published in Frontiers in cellular neuroscience (22-07-2021)“…The perirhinal cortex (PRC) is a polymodal associative region of the temporal lobe that works as a gateway between cortical areas and hippocampus. In recent…”
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Lysosomal TRPML1 triggers global Ca 2+ signals and nitric oxide release in human cerebrovascular endothelial cells
Published in Frontiers in physiology (2024)“…Lysosomal Ca signaling is emerging as a crucial regulator of endothelial Ca dynamics. Ca release from the acidic vesicles in response to extracellular…”
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Novel multitarget directed ligands inspired by riluzole: A serendipitous synthesis of substituted benzob1,4thiazepines potentially useful as neuroprotective agents
Published in Bioorganic & medicinal chemistry (01-10-2024)“…Riluzole, the first clinically approved treatment for amyotrophic lateral sclerosis (ALS), represents a successful example of a drug endowed with a multimodal…”
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Olfactory input to the parahippocampal region of the isolated guinea pig brain reveals weak entorhinal-to-perirhinal interactions
Published in The European journal of neuroscience (01-07-2003)“…The processing of olfactory inputs by the parahippocampal region has a central role in the organization of memory in mammals. The olfactory input is relayed to…”
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