Search Results - "Biela, Anna"

Disposable MMP-9 sensor based on the degradation of peptide cross-linked hydrogel films using electrochemical impedance spectroscopy by Biela, Anna, Watkinson, Michael, Meier, Ute C, Baker, David, Giovannoni, Gavin, Becer, C Remzi, Krause, Steffi

“…Matrix metalloproteinase-9 (MMP-9) plays an important role in both physiological and pathological processes. This enzyme is a peripheral biomarker of…”
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How Elongator Acetylates tRNA Bases by Abbassi, Nour-El-Hana, Biela, Anna, Glatt, Sebastian, Lin, Ting-Yu

“…Elp3, the catalytic subunit of the eukaryotic Elongator complex, is a lysine acetyltransferase that acetylates the C5 position of wobble-base uridines (U ) in…”
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Functional divergence of the two Elongator subcomplexes during neurodevelopment by Gaik, Monika, Kojic, Marija, Stegeman, Megan R, Öncü‐Öner, Tülay, Kościelniak, Anna, Jones, Alun, Mohamed, Ahmed, Chau, Pak Yan Stefanie, Sharmin, Sazia, Chramiec‐Głąbik, Andrzej, Indyka, Paulina, Rawski, Michał, Biela, Anna, Dobosz, Dominika, Millar, Amanda, Chau, Vann, Ünalp, Aycan, Piper, Michael, Bellingham, Mark C, Eichler, Evan E, Nickerson, Deborah A, Güleryüz, Handan, Abbassi, Nour El Hana, Jazgar, Konrad, Davis, Melissa J, Mercimek‐Andrews, Saadet, Cingöz, Sultan, Wainwright, Brandon J, Glatt, Sebastian

“…The highly conserved Elongator complex is a translational regulator that plays a critical role in neurodevelopment, neurological diseases, and brain tumors…”
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Iminosugar-Based Galactoside Mimics as Inhibitors of Galactocerebrosidase: SAR Studies and Comparison with Other Lysosomal Galactosidases by Biela-Banaś, Anna, Oulaïdi, Farah, Front, Sophie, Gallienne, Estelle, Ikeda-Obatake, Kyoko, Asano, Naoki, Wenger, David A., Martin, Olivier R.

“…Several families of iminosugar‐based galactoside mimics were designed, synthesized, and evaluated as galactocerebrosidase (GALC) inhibitors. They were also…”
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Stereoselective synthesis of 1-C-alkyl iminogalactitol derivatives, potential chaperones for galactosidase-linked LSDs: a real challenge by Biela-Banaś, Anna, Gallienne, Estelle, Front, Sophie, Martin, Olivier R.

“…1-C-Alkyl iminogalactitol derivatives are highly desirable target compounds as potential pharmacological chaperones for the treatment of galactosidase-linked…”
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Synthetically Lethal Interactions of Heme Oxygenase-1 and Fumarate Hydratase Genes by Podkalicka, Paulina, Mucha, Olga, Kruczek, Szczepan, Biela, Anna, Andrysiak, Kalina, Stępniewski, Jacek, Mikulski, Maciej, Gałęzowski, Michał, Sitarz, Kamil, Brzózka, Krzysztof, Józkowicz, Alicja, Dulak, Józef, Łoboda, Agnieszka

“…Elevated expression of heme oxygenase-1 (HO-1, encoded by ) is observed in various types of tumors. Hence, it is suggested that HO-1 may serve as a potential…”
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The diverse structural modes of tRNA binding and recognition by Biela, Anna, Hammermeister, Alexander, Kaczmarczyk, Igor, Walczak, Marta, Koziej, Lukasz, Lin, Ting-Yu, Glatt, Sebastian

“…tRNAs are short noncoding RNAs responsible for decoding mRNA codon triplets, delivering correct amino acids to the ribosome, and mediating polypeptide chain…”
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α-Amylase sensor based on the degradation of oligosaccharide hydrogel films monitored with a quartz crystal sensor by Gibbs, Martin John, Biela, Anna, Krause, Steffi

“…α-Amylase hydrolyses starch molecules to produce smaller oligosaccharides and sugars. Amylases are of great importance in biotechnology and find application in…”
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A reinvestigation of the synthesis and revision of spectral data of 1,2-O-isopropylidene-α-l-sorbofuranose, 1,2:4,6-di-O-isopropylidene-α-l-sorbofuranose and derivatives by Biela-Banaś, Anna, Gallienne, Estelle, Martin, Olivier R.

“…[Display omitted] •Unambiguous syntheses of 1,2-O-isopropylidene-α-l-sorbofuranoses substituted at O-3 and of isomeric 2,3-O-isopropylidene-α-l-sorbofuranoses…”
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A Specific Activity‐Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease by Marques, André R. A., Willems, Lianne I., Herrera Moro, Daniela, Florea, Bogdan I., Scheij, Saskia, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Verhoek, Marri, Nelson, Jessica K., Kallemeijn, Wouter W., Biela‐Banas, Anna, Martin, Olivier R., Cachón‐González, M. Begoña, Kim, Nee Na, Cox, Timothy M., Boot, Rolf G., Overkleeft, Herman S., Aerts, Johannes M. F. G.

“…Galactosylceramidase (GALC) is the lysosomal β‐galactosidase responsible for the hydrolysis of galactosylceramide. Inherited deficiency in GALC causes Krabbe…”
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Cryo-EM structure of the fully assembled Elongator complex by Jaciuk, Marcin, Scherf, David, Kaszuba, Karol, Gaik, Monika, Rau, Alexander, Kościelniak, Anna, Krutyhołowa, Rościsław, Rawski, Michał, Indyka, Paulina, Graziadei, Andrea, Chramiec-Głąbik, Andrzej, Biela, Anna, Dobosz, Dominika, Lin, Ting-Yu, Abbassi, Nour-el-Hana, Hammermeister, Alexander, Rappsilber, Juri, Kosinski, Jan, Schaffrath, Raffael, Glatt, Sebastian

“…Abstract Transfer RNA (tRNA) molecules are essential to decode messenger RNA codons during protein synthesis. All known tRNAs are heavily modified at multiple…”
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Destabilization of mutated human PUS3 protein causes intellectual disability by Lin, Ting‐Yu, Smigiel, Robert, Kuzniewska, Bozena, Chmielewska, Joanna J., Kosińska, Joanna, Biela, Mateusz, Biela, Anna, Kościelniak, Anna, Dobosz, Dominika, Laczmanska, Izabela, Chramiec‐Głąbik, Andrzej, Jeżowski, Jakub, Nowak, Jakub, Gos, Monika, Rzonca‐Niewczas, Sylwia, Dziembowska, Magdalena, Ploski, Rafał, Glatt, Sebastian

“…Pseudouridine (Ψ) is an RNA base modification ubiquitously found in many types of RNAs. In humans, the isomerization of uridine is catalyzed by different…”
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Development and characterization of a new inhibitor of heme oxygenase activity for cancer treatment by Mucha, Olga, Podkalicka, Paulina, Mikulski, Maciej, Barwacz, Szymon, Andrysiak, Kalina, Biela, Anna, Mieczkowski, Mateusz, Kachamakova-Trojanowska, Neli, Ryszawy, Damian, Białas, Arkadiusz, Szelążek, Bożena, Grudnik, Przemysław, Majewska, Eliza, Michalik, Kinga, Jakubiec, Krzysztof, Bień, Marcin, Witkowska, Natalia, Gluza, Karolina, Ekonomiuk, Dariusz, Sitarz, Kamil, Gałęzowski, Michał, Brzózka, Krzysztof, Dubin, Grzegorz, Józkowicz, Alicja, Dulak, Józef, Łoboda, Agnieszka

“…Heme oxygenase-1 (HO-1, HMOX1) degrades pro-oxidant heme into carbon monoxide (CO), ferrous ions (Fe2+) and biliverdin. The enzyme exerts multiple…”
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An improved methodology for the synthesis of 1-C-allyl imino-d-xylitol and -l-arabinitol and their rapid functionalization by Biela, Anna, Oulaïdi, Farah, Gallienne, Estelle, Górecki, Marcin, Frelek, Jadwiga, Martin, Olivier R.

“…As part of our research program dedicated to the design and synthesis of new iminosugars as pharmacological chaperones for the treatment of lysosomal storage…”
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Pharmacological versus genetic inhibition of heme oxygenase-1 – the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system by Mucha, Olga, Podkalicka, Paulina, Czarnek, Maria, Biela, Anna, Mieczkowski, Mateusz, Kachamakova-Trojanowska, Neli, Stępniewski, Jacek, Józkowicz, Alicja, Dulak, Józef, Łoboda, Agnieszka

“…Inhibition of heme oxygenase-1 (HO-1, encoded by HMOX1), a cytoprotective, anti-apoptotic and anti-inflammatory enzyme, may be a valuable therapy in various…”
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Comparison of shRNA and CRISPR/Cas9 in heme oxygenase-1 targeting efficiency by Loboda, Agnieszka, Czauderna, Szymon, Mucha, Olga, Podkalicka, Paulina, Czarnek, Maria, Biela, Anna, Mieczkowski, Mateusz, Stepniewski, Jacek, Kachamakova-Trojanowska, Neli, Jozkowicz, Alicja, Dulak, Jozef

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Biomimetic sensors for hba1c by Biela, Anna

“…Diabetes mellitus is a growing health problem worldwide. Suitable long-term control and management of this disease are enabled by determination of glycated…”
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(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B by Front, Sophie, Biela-Banaś, Anna, Burda, Patricie, Ballhausen, Diana, Higaki, Katsumi, Caciotti, Anna, Morrone, Amelia, Charollais-Thoenig, Julie, Gallienne, Estelle, Demotz, Stéphane, Martin, Olivier R.

“…This report is about the identification, synthesis and initial biological characterization of derivatives of 4-epi-isofagomine as pharmacological chaperones…”
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