Search Results - "Biekofsky, Rodolfo R."

Natural AD-Like Neuropathology in Octodon degus: Impaired Burrowing and Neuroinflammation by Deacon, Robert M J, Altimiras, Francisco J, Bazan-Leon, Enrique A, Pyarasani, Rhada D, Nachtigall, Fabiane M, Santos, Leonardo S, Tsolaki, Anthony G, Pednekar, Lina, Kishore, Uday, Biekofsky, Rodolfo R, Vasquez, Rodrigo A, Cogram, Patricia

“…Alzheimer's disease (AD) is the most common cause of dementia, affecting more than 36 million people worldwide. Octodon degus, a South American rodent, has…”
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Reaction Path Analysis from Potential Energy Contributions Using Forces: An Accessible Estimator of Reaction Coordinate Adequacy by Foglia, Nicolás O, González Lebrero, Mariano C, Biekofsky, Rodolfo R, Estrin, Darío A

“…The calculation of potential energy and free-energy profiles along complex chemical reactions or rare event processes is of great interest because of their…”
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NNZ-2566, a Novel Analog of (1–3) IGF-1, as a Potential Therapeutic Agent for Fragile X Syndrome by Deacon, Robert M. J., Glass, Larry, Snape, Mike, Hurley, Michael J., Altimiras, Francisco J., Biekofsky, Rodolfo R., Cogram, Patricia

“…Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the…”
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Cooperative cyclic interactions involved in metal binding to pairs of sites in EF-hand proteins by Biekofsky, Rodolfo R, Feeney, James

“…This study focuses on a closed net of electron-pair donor–acceptor interactions, present in the core of all metal-bound EF-hand pairs, that link both metal…”
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NMR and molecular dynamics studies of the interaction of melatonin with calmodulin by Turjanski, Adrián G., Estrin, Darío A., Rosenstein, Ruth E., McCormick, John E., Martin, Stephen R., Pastore, Annalisa, Biekofsky, Rodolfo R., Martorana, Vincenzo

“…Pineal hormone melatonin (N‐acetyl‐5‐methoxytryptamine) is thought to modulate the calcium/calmodulin signaling pathway either by changing intracellular Ca2+…”
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Interaction of calmodulin with the phosphofructokinase target sequence by Martin, Stephen R., Biekofsky, Rodolfo R., Skinner, Murray A., Guerrini, Remo, Salvadori, Severo, Feeney, James, Bayley, Peter M.

“…Ca 4 · calmodulin (Ca 4 · CaM) inhibits the glycolytic enzyme phosphofructokinase, by preventing formation of its active tetramer. Fluorescence titrations show…”
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Thermal stability of calmodulin and mutants studied by (1)H-(15)N HSQC NMR measurements of selectively labeled [(15)N]Ile proteins by Biekofsky, Rodolfo R, Martin, Stephen R, McCormick, John E, Masino, Laura, Fefeu, Sandrine, Bayley, Peter M, Feeney, James

“…Calmodulin, the Ca(2+)-dependent activator of many cellular processes, contains two well-defined structural domains, each of which binds two Ca(2+) ions. In…”
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Ab Initio Study of NMR 15N Chemical Shift Differences Induced by Ca2+ Binding to EF-Hand Proteins by Biekofsky, Rodolfo R, Turjanski, Adrián G, Estrin, Darío A, Feeney, James, Pastore, Annalisa

“…EF-hands are Ca2+ binding motifs that are widely distributed throughout the entire living organism kingdom. At present, relatively little is known at a quantum…”
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Towards understanding the origins of the different specificities of binding the reduced (NADPH) and oxidised (NADP +) forms of nicotinamide adenine dinucleotide phosphate coenzyme to dihydrofolate reductase by Polshakov, Vladimir I, Biekofsky, Rodolfo R, Birdsall, Berry, Feeney, James

“…Lactobacillus casei dihydrofolate reductase (DHFR) binds more than a thousand times tighter to NADPH than to NADP +. The origins of the difference in binding…”
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Calcium-Induced Refolding of the Calmodulin V136G Mutant Studied by NMR Spectroscopy:  Evidence for Interaction between the Two Globular Domains by Fefeu, Sandrine, Biekofsky, Rodolfo R, McCormick, John E, Martin, Stephen R, Bayley, Peter M, Feeney, James

“…The Ca2+ titration of the 15N-labeled mutant V136G calmodulin has been monitored using 1H−15N HSQC NMR spectra. Up to a [Ca2+]/[CaM] ratio of 2, the Ca2+ ions…”
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Thermal Stability of Calmodulin and Mutants Studied by 1H−15N HSQC NMR Measurements of Selectively Labeled [15N]Ile Proteins by Biekofsky, Rodolfo R, Martin, Stephen R, McCormick, John E, Masino, Laura, Fefeu, Sandrine, Bayley, Peter M, Feeney, James

“…Calmodulin, the Ca2+-dependent activator of many cellular processes, contains two well-defined structural domains, each of which binds two Ca2+ ions. In its…”
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Ca2+ Coordination to Backbone Carbonyl Oxygen Atoms in Calmodulin and Other EF-Hand Proteins:  15N Chemical Shifts as Probes for Monitoring Individual-Site Ca2+ Coordination by Biekofsky, Rodolfo R, Martin, Stephen R, Browne, J. Peter, Bayley, Peter M, Feeney, James

“…Examination of the NMR 15N chemical shifts of a number of EF-hand proteins shows that the shift value for the amido nitrogen of the residue in position 8 of a…”
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Effects of electronic resonance interaction on methoxy group NMR parameters: theoretical and experimental study of substituted 2-methoxypyridines by Contreras, Ruben H, Biekofsky, Rodolfo R, De Kowalewski, Dora G, Orendt, Anita M, Facelli, Julio C

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NMR approaches for monitoring domain orientations in calcium‐binding proteins in solution using partial replacement of Ca2+ by Tb3 by Biekofsky, Rodolfo R., Muskett, Frederick W., Schmidt, Jürgen M., Martin, Stephen R., Browne, J.Peter, Bayley, Peter M., Feeney, James

“…This work shows that the partial replacement of diamagnetic Ca2+ by paramagnetic Tb3+ in Ca2+/calmodulin systems in solution allows the measurement of…”
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Ab Initio Study of NMR 15 N Chemical Shift Differences Induced by Ca 2+ Binding to EF-Hand Proteins by Biekofsky, Rodolfo R., Turjanski, Adrián G., Estrin, Darío A., Feeney, James, Pastore, Annalisa

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Ab initio and oxygen-17 NMR study of aromatic compounds with dicoordinate oxygen atoms. 2. Intramolecular hydrogen bonding in hydroxy- and methoxybenzene derivatives by Orendt, Anita M, Biekofsky, Rodolfo R, Pomilio, Alicia B, Contreras, Ruben H, Facelli, Julio C

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Ab initio and oxygen-17 NMR study of aromatic compounds with dicoordinate oxygen atoms. 1. Methoxy- and (methylenedioxy)benzene derivatives by Biekofsky, Rodolfo R, Pomilio, Alicia B, Contreras, Ruben H, Orendt, Anita M, Facelli, Julio C

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Thermal Stability of Calmodulin and Mutants Studied by 1 H− 15 N HSQC NMR Measurements of Selectively Labeled [ 15 N]Ile Proteins by Biekofsky, Rodolfo R., Martin, Stephen R., McCormick, John E., Masino, Laura, Fefeu, Sandrine, Bayley, Peter M., Feeney, James

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NMR approaches for monitoring domain orientations in calcium-binding proteins in solution using partial replacement of Ca 2+ by Tb 3 by Biekofsky, Rodolfo R., Muskett, Frederick W., Schmidt, Jürgen M., Martin, Stephen R., Browne, J.Peter, Bayley, Peter M., Feeney, James

“…This work shows that the partial replacement of diamagnetic Ca 2+ by paramagnetic Tb 3+ in Ca 2+/calmodulin systems in solution allows the measurement of…”
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Ca 2+ Coordination to Backbone Carbonyl Oxygen Atoms in Calmodulin and Other EF-Hand Proteins:  15 N Chemical Shifts as Probes for Monitoring Individual-Site Ca 2+ Coordination by Biekofsky, Rodolfo R., Martin, Stephen R., Browne, J. Peter, Bayley, Peter M., Feeney, James

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