Search Results - "Biehl, Edward R"

Enantioselective Reduction of Diaryl Ketones Catalyzed by a Carbonyl Reductase from Sporobolomyces salmonicolor and its Mutant Enzymes by Li, Hongmei, Zhu, Dunming, Hua, Ling, Biehl, Edward R.

“…The carbonyl reductase from red yeast Sporobolomyces salmonicolor AKU4429 (SSCR) and its mutant enzymes effectively catalyzed the enantioselective reduction of…”
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Synthesis of Novel 5-Aryl/Hetarylidenyl 3-(2-Methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-2-thioxothiazolidin-4-ones by R. Biehl, Edward, Mendoza, Kimberly, Kamila, Sukanta

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Microwave assisted synthesis of novel functionalized hydantoin derivatives and their conversion to 5-(Z) arylidene-4H-imidazoles by Kamila, Sukanta, Ankati, Haribabu, Biehl, Edward R

“…2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a-n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding…”
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Nitrilase-Catalyzed Selective Hydrolysis of Dinitriles and Green Access to the Cyanocarboxylic Acids of Pharmaceutical Importance by Zhu, Dunming, Mukherjee, Chandrani, Biehl, Edward R., Hua, Ling

“…To further explore its synthetic applications, the nitrilase bll6402 from Bradyrhizobium japonicum strain USDA110 has been examined toward the hydrolysis of…”
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Cloning, Protein Sequence Clarification, and Substrate Specificity of a Leucine Dehydrogenase from Bacillus sphaericus ATCC4525 by Li, Hongmei, Zhu, Dunming, Hyatt, Brooke A, Malik, Fahad M, Biehl, Edward R, Hua, Ling

“…Although an X-ray model sequence of a leucine dehydrogenase from Bacillus sphaericus ATCC4525 was reported, the amino acid sequence of this enzyme has not been…”
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Synthesis and structure-activity relationship studies of 3-substituted indolin-2-ones as effective neuroprotective agents by Balderamos, Michael, Ankati, Haribabu, Akubathini, Shashidhar Kumar, Patel, Anish V, Kamila, Sukanta, Mukherjee, Chandrani, Wang, Lulu, Biehl, Edward R, D'Mello, Santosh R

“…Neurodegenerative diseases are a major health problem particularly among the elderly. Drugs to prevent or slow down the death of neurons are urgently needed…”
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Synthetic Studies of Bioactive Quinoxalinones: A Facile Approach to Potent Euglycemic and Hypolipidemic Agents by R. Biehl, Edward, Kamila, Sukanta

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Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones and thioureas by Kamila, Sukanta, Mendoza, Kimberly, Biehl, Edward R.

“…N-Phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines (6a–q) have been synthesized by the Hantzsch thiazole reaction of…”
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An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors by Kamila, Sukanta, Ankati, Haribabu, Biehl, Edward R.

“…(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one (7a–q) derivatives have been synthesized by the condensation reaction of…”
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The Crystal Structure of Palmitoyl Protein Thioesterase-2 (PPT2) Reveals the Basis for Divergent Substrate Specificities of the Two Lysosomal Thioesterases, PPT1 and PPT2 by Calero, Guillermo, Gupta, Praveena, Nonato, M.Cristina, Tandel, Sagun, Biehl, Edward R., Hofmann, Sandra L., Clardy, Jon

“…Mutations in palmitoyl protein thioesterase-1 (PPT1) have been found to cause the infantile form of neuronal ceroid lipofuscinosis, which is a lysosomal…”
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Easy and Rapid Method for Disulfide Syntheses Using Nanophase-Manganese (VII) Oxide Coated Clay by Gondi, Sudershan R., Son, David Y., Biehl, Edward R., Vempati, Rajan K.

“…Disulfide bond formation by the oxidation of several thiol compounds using nanophase manganese (VII) oxide coated clay (NM7O coated clay) in chlorinated,…”
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Asymmetric Synthesis of Both Antipodes of β-Hydroxy Nitriles and β-Hydroxy Carboxylic Acids via Enzymatic Reduction or Sequential Reduction/Hydrolysis by Ankati, Haribabu, Zhu, Dunming, Yang, Yan, Biehl, Edward R, Hua, Ling

“…Use of isolated carbonyl reductases in the reduction of aromatic β-ketonitriles have completely eliminated the competing α-ethylation, which is often observed…”
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A facile synthesis of novel 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones using microwave heating by Kamila, Sukanta, Ankati, Haribabu, Harry, Emily, Biehl, Edward R.

“…(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones (7a–w) have been synthesized by the Knoevenagel condensation…”
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Synthesis of Optically Pure 2-Azido-1-arylethanols with Isolated Enzymes and Conversion to Triazole-Containing β-Blocker Analogues Employing Click Chemistry by Ankati, Haribabu, Yang, Yan, Zhu, Dunming, Biehl, Edward R, Hua, Ling

“…Both antipodes of 2-azido-1-arylethanols were synthesized with excellent optical purity via enzymatic reduction of the corresponding α-azidoacetophenone…”
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Unexpected Stereorecognition in Nitrilase-Catalyzed Hydrolysis of β-Hydroxy Nitriles by Kamila, Sukanta, Zhu, Dunming, Biehl, Edward R, Hua, Ling

“…Biocatalytic enantioselective hydrolysis of β-hydroxy nitriles to corresponding (S)-enriched β-hydroxy carboxylic acids has been achieved for the first time by…”
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Asymmetric Reduction of β-Ketonitriles with a Recombinant Carbonyl Reductase and Enzymatic Transformation to Optically Pure β-Hydroxy Carboxylic Acids by Zhu, Dunming, Ankati, Haribabu, Mukherjee, Chandrani, Yang, Yan, Biehl, Edward R, Hua, Ling

“…α-Ethylation is concomitant with the reduction of aromatic β-ketonitriles catalyzed by whole-cell biocatalysts. Use of isolated carbonyl reductase has…”
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New Synthesis of of 3H-Benzo[b]thiophen-2-ones by R. Biehl, Edward, Kamila, Sukanta

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new nitrilase from Bradyrhizobium japonicum USDA 110: gene cloning, biochemical characterization and substrate specificity by Zhu, Dunming, Mukherjee, Chandrani, Yang, Yan, Rios, Beatriz E, Gallagher, D. Travis, Smith, N. Natasha, Biehl, Edward R, Hua, Ling

“…A nitrilase gene blr3397 from Bradyrhizobium japonicum USDA110 was cloned and over-expressed in Escherichia coli, and the encoded protein was purified to give…”
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Identification of novel 1,4-benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration by Wang, Lulu, Ankati, Haribabu, Akubathini, Shashidhar Kumar, Balderamos, Michael, Storey, Chelsey A., Patel, Anish V., Price, Valerie, Kretzschmar, Doris, Biehl, Edward R., D'Mello, Santosh R.

“…Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease and conditions such as ischemic stroke affect millions of…”
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Synthesis of (2-chlorophenyl)(phenyl)methanones and 2-(2-chlorophenyl)-1-phenylethanones by Friedel–Crafts acylation of 2-chlorobenzoic acids and 2-(2-chlorophenyl)acetic acids using microwave heating by Mahdi, Jasia, Ankati, Haribabu, Gregory, Jill, Tenner, Brian, Biehl, Edward R.

“…Several 2-(2-chlorophenyl)-1-phenylethanones and (2-chlorophenyl)(phenyl)methanones were prepared by the Friedel–Crafts acylation reaction of…”
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