Search Results - "Bieganowski, P"

Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers by Pace, H.C, Hodawadekar, S.C, Draganescu, A, Huang, J, Bieganowski, P, Pekarsky, Y, Croce, C.M, Brenner, C

“…Background: The nucleotide-binding protein Fhit, among the earliest and most frequently inactivated proteins in lung cancer, suppresses tumor formation by…”
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Yeast myosin light chain, Mlc1p, interacts with both IQGAP and class II myosin to effect cytokinesis by Boyne, J R, Yosuf, H M, Bieganowski, P, Brenner, C, Price, C

“…MLC1 (myosin light chain) acts as a dosage suppressor of a temperature sensitive mutation in the gene encoding the S. cerevisiae IQGAP protein. Both proteins…”
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Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD + in Fungi and Humans by Bieganowski, Pawel, Brenner, Charles

“…NAD + is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADPribosyl groups used in various reactions, including…”
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The ataxia–oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4 by Clements, Paula M., Breslin, Claire, Deeks, Emma D., Byrd, Philip J., Ju, Limei, Bieganowski, Pawel, Brenner, Charles, Moreira, Maria-Céu, Taylor, A. Malcolm R., Caldecott, Keith W.

“…Ataxia–oculomotor apraxia 1 (AOA1) is an autosomal recessive neurodegenerative disease that is reminiscent of ataxia–telangiectasia (A–T). AOA1 is caused by…”
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Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD super(+) in Fungi and Humans by Bieganowski, P, Brenner, C

“…NAD super(+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADPribosyl groups used in various reactions,…”
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Hsp70 is a new target of Sgt1—an interaction modulated by S100A6 by Spiechowicz, Magdalena, Zylicz, Alicja, Bieganowski, Paweł, Kuznicki, Jacek, Filipek, Anna

“…In this work, we identified Hsp70 as a novel target of the Sgt1 protein. Using co-immunoprecipitation, affinity chromatography and ELISA we showed that,…”
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Disease-associated Mutations Inactivate AMP-Lysine Hydrolase Activity of Aprataxin by Seidle, Heather F., Bieganowski, Pawel, Brenner, Charles

“…Ataxia-oculomotor apraxia syndrome 1 is an early onset cerebellar ataxia that results from loss of function mutations in the APTX gene, encoding Aprataxin,…”
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Cdc123 and Checkpoint Forkhead Associated with RING Proteins Control the Cell Cycle by Controlling eIF2γ Abundance by Bieganowski, Pawel, Shilinski, Kara, Tsichlis, Philip N., Brenner, Charles

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Eukaryotic NAD+ Synthetase Qns1 Contains an Essential, Obligate Intramolecular Thiol Glutamine Amidotransferase Domain Related to Nitrilase by Bieganowski, Pawel, Pace, Helen C., Brenner, Charles

“…NAD+ is an essential co-enzyme for redox reactions and is consumed in lysine deacetylation and poly(ADP-ribosyl)ation. NAD+ synthetase catalyzes the final step…”
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Adenosine Monophosphoramidase Activity of Hint and Hnt1 Supports Function of Kin28, Ccl1, and Tfb3 by Bieganowski, Pawel, Garrison, Preston N., Hodawadekar, Santosh C., Faye, Gerard, Barnes, Larry D., Brenner, Charles

“…The histidine triad superfamily of nucleotide hydrolases and nucleotide transferases consists of a branch of proteins related to Hint and Aprataxin, a branch…”
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Miniature planar chloride electrodes by Paciorek, Renata, Bieganowski, Przemysław, Maj-Żurawska, Magdalena

“…Miniature solid-contacted electrodes for chloride ions were investigated. As an inner contact, the electrochemically deposited gold on screen-printed silver…”
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The histidine triad superfamily of nucleotide-binding proteins by Brenner, Charles, Bieganowski, Pawel, Pace, Helen C., Huebner, Kay

“…Histidine triad (HIT) proteins were until recently a superfamily of proteins that shared only sequence motifs. Crystal structures of nucleotide‐bound forms of…”
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Eukaryotic NAD super(+) Synthetase Qns1 Contains an Essential, Obligate Intramolecular Thiol Glutamine Amidotransferase Domain Related to Nitrilase by Bieganowski, P, Pace, H C, Brenner, C

“…NAD super(+) is an essential co-enzyme for redox reactions and is consumed in lysine deacetylation and poly(ADP-ribosyl)ation. NAD super(+) synthetase…”
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Designed FHIT Alleles Establish That Fhit-Induced Apoptosis in Cancer Cells Is Limited by Substrate Binding by Trapasso, Francesco, Krakowiak, Agnieszka, Cesari, Rossano, Arkles, Jeffrey, Yendamuri, Sai, Ishii, Hideshi, Vecchione, Andrea, Kuroki, Tamotsu, Bieganowski, Pawel, Pace, Helen C., Huebner, Kay, Croce, Carlo M., Brenner, Charles

“…The FHIT gene is inactivated early in the development of many human tumors, and Fhit-deficient mice have increased cancer incidence. Viral reexpression of Fhit…”
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The Reported Human NADsyn2 Is Ammonia-dependent NAD Synthetase from a Pseudomonad by Bieganowski, Pawel, Brenner, Charles

“…Nicotinamide-adenine dinucleotide (NAD+) synthetases catalyze the last step in NAD+ metabolism in the de novo, import, and salvage pathways that originate from…”
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Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination by Parks, Kristen P, Seidle, Heather, Wright, Nathan, Sperry, Jeffrey B, Bieganowski, Pawel, Howitz, Konrad, Wright, Dennis L, Brenner, Charles

“…1 Departments of Genetics and Biochemistry and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 2 Department of Chemistry,…”
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Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae by Rubio-Texeira, Marta, Varnum, James M, Bieganowski, Pawel, Brenner, Charles

“…The FHIT gene is lost early in the development of many tumors. Fhit possesses intrinsic ApppA hydrolase activity though ApppA cleavage is not required for…”
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Alternative Forms of β-pol mRNA Are Not Tumor-Specific and Are Not the Result of Mutations in the DNA by Nowak, Radoslawa, Bieganowski, Pawel, Konopinski, Ryszard, Siedlecki, Janusz A.

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Alternative spliciung of DNA polymerase β mRNA is not tumor-specific by NOWAK, R, BIEGANOWSKI, P, KONPINSKI, R, SIEDLECKI, J. A

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Oligoclonal expansion of gamma delta T cells in cerebrospinal fluid of multiple sclerosis patients by Bieganowski, P, Bieganowska, K, Zaborski, J, Członkowska, A

“…We have used a PCR based method to analyse TCR gamma chain repertoire and clonality of gamma delta T cells in the CSF and blood of II MS patients. Samples…”
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