Search Results - "Bie Thomsen, Alex Rojas"

Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR) by Strachan, Ryan T., Sun, Jin-peng, Rominger, David H., Violin, Jonathan D., Ahn, Seungkirl, Rojas Bie Thomsen, Alex, Zhu, Xiao, Kleist, Andrew, Costa, Tommaso, Lefkowitz, Robert J.

“…The concept of “biased agonism” arises from the recognition that the ability of an agonist to induce a receptor-mediated response (i.e. “efficacy”) can differ…”
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β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor by Daly, Carole, Guseinov, Akim Abdul, Hahn, Hyunggu, Wright, Adam, Tikhonova, Irina G, Thomsen, Alex Rojas Bie, Plouffe, Bianca

“…The vasopressin type 2 receptor (V R) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the V R…”
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Novel strategies in drug discovery of the calcium-sensing receptor based on biased signaling by Thomsen, Alex Rojas Bie, Smajilovic, Sanela, Bräuner-Osborne, Hans

“…A hallmark of chronic kidney disease is hyperphosphatemia due to renal phosphate retention. Prolonged parathyroid gland exposure to hyperphosphatemia leads to…”
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Synthesis of the calcilytic ligand NPS 2143 by Johansson, Henrik, Cailly, Thomas, Rojas Bie Thomsen, Alex, Bräuner-Osborne, Hans, Sejer Pedersen, Daniel

“…(R)-3 (NPS 2143) is a negative allosteric modulator of the human calcium-sensing receptor (CaSR) and as such represents an important pharmacological tool…”
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Biased agonism of the calcium-sensing receptor by Thomsen, Alex Rojas Bie, Hvidtfeldt, Maja, Bräuner-Osborne, Hans

“…Abstract After the discovery of molecules modulating G protein-coupled receptors (GPCRs) that are able to selectively affect one signaling pathway over others…”
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G protein-coupled receptor signaling analysis using homogenous time-resolved Förster resonance energy transfer (HTRF®) technology by Nørskov-Lauritsen, Lenea, Thomsen, Alex Rojas Bie, Bräuner-Osborne, Hans

“…Studying multidimensional signaling of G protein-coupled receptors (GPCRs) in search of new and better treatments requires flexible, reliable and sensitive…”
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Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor by Jacobsen, Stine Engesgaard, Nørskov-Lauritsen, Lenea, Thomsen, Alex Rojas Bie, Smajilovic, Sanela, Wellendorph, Petrine, Larsson, Niklas H P, Lehmann, Anders, Bhatia, Vikram Kjøller, Bräuner-Osborne, Hans

“…The GPRC6A receptor is a recently "deorphanized" class C G protein-coupled receptor. We and others have shown that this receptor is coactivated by basic…”
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Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells by Thomsen, Alex Rojas Bie, Worm, Jesper, Jacobsen, Stine Engesgaard, Stahlhut, Martin, Latta, Markus, Bräuner-Osborne, Hans

“…The calcium-sensing receptor (CaSR)-specific allosteric modulator cinacalcet has revolutionized the treatment of secondary hyperparathyroidism in patients with…”
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Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in Danish hypertrophic cardiomyopathy patients and relatives by Andersen, Paal Skytt, Havndrup, Ole, Hougs, Lotte, Sørensen, Karina M, Jensen, Morten, Larsen, Lars Allan, Hedley, Paula, Bie Thomsen, Alex Rojas, Moolman-Smook, Johanna, Christiansen, Michael, Bundgaard, Henning

“…The American Heart Association (AHA) recommends family screening for hypertrophic cardiomyopathy (HCM). We assessed the outcome of family screening combining…”
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Chemogenomic Discovery of Allosteric Antagonists at the GPRC6A Receptor by Gloriam, David E., Wellendorph, Petrine, Johansen, Lars D., Thomsen, Alex Rojas Bie, Phonekeo, Karina, Pedersen, Daniel Sejer, Bräuner-Osborne, Hans

“…GPRC6A is a Family C G protein-coupled receptor recently discovered and deorphanized by our group. This study integrates chemogenomic ligand inference,…”
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β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor by Daly, Carole, Guseinov, Akim Abdul, Hahn, Hyunggu, Wright, Adam, Tikhonova, Irina G, Thomsen, Alex Rojas Bie, Plouffe, Bianca

“…The vasopressin type 2 receptor (V 2 R) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the V 2 R…”
Get full text

Synthesis of the calcilytic ligand NPS 2143 by Johansson, Henrik, Cailly, Thomas, Rojas Bie Thomsen, Alex, Bräuner-Osborne, Hans, Pedersen Sejer, Daniel

“…(R)-3 (NPS 2143) is a negative allosteric modulator of the human calcium-sensing receptor (CaSR) and as such represents an important pharmacological tool…”
Get full text