Search Results - "Bidye, Durgesh"

Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis by Singh, Manisha, Batt, Sarah M, Canales, Christian S C, Pavan, Fernando R, Kumar, Sethu Arun, Akshatha, Handattu S, Bhagyalalitha, Meduri, Pujar, Karthik G, Bidye, Durgesh, Pujar, Gurubasavaraj V, Besra, Gurdyal S

“…Decaprenylphosphoryl-β-D-ribose-oxidase (DprE1), a subunit of the essential decaprenylphosphoribose-2'-epimerase, plays a crucial role in the synthesis of cell…”
Get full text

Nicotinamide-based agglomerates of ibuprofen: formulation, solid state characterization and evaluation of tableting performance with in-silico investigation by Sidwadkar, Prerna Hemant, Salunkhe, Nitin Hindurao, Mali, Kailas Krishnat, Metkari, Vijay Bapu, Bidye, Durgesh Paresh

“…Background The objective of the present investigation was to obtain directly compressible agglomerates of ibuprofen with nicotinamide by a quasi-emulsification…”
Get full text

Restoration of p53 functions by suppression of mortalin–p53 sequestration: an emerging target in cancer therapy by Shankaranarayana, Akshatha Handattu, Meduri, Bhagyalalitha, Pujar, Gurubasavaraj Veeranna, Hariharapura, Raghu Chandrashekar, Sethu, Arun Kumar, Singh, Manisha, Bidye, Durgesh

“…Functional inactivation of wild-type p53 is a major trait of cancerous cells. In many cases, such inactivation occurs by either gene mutations or due to…”
Get full text

New LPA1 receptor modulators: Design, synthesis, in-silico, and anticancer studies of triazole and oxadiazole analogs by Meduri, Bhagyalalitha, S R, Pavan, Prabhu, Ashwini, Handattu Shankaranarayana, Akshatha, Sethu, Arun Kumar, Singh, Manisha, Pujar, Karthik G, BC, Revana Siddappa, Bidye, Durgesh, Pujar, Gurubasavaraj Veeranna

“…•LPA1 receptors are overexpressed in breast cancer and activated by Lysophosphatidic acid (LPA).•Blocking the LPA-LPA1 signaling by small molecules may benefit…”
Get full text

Novel β-L-1,3-thiazolidine pyrimidine nucleoside analogues: Design, synthesis, molecular docking, and anti-HIV activity by Sriharsha, Shimoga Nagaraj, Jainab, N．Habeela, Biradar, Mahalakshmi Suresha, Thapa, Shankar, Venkatesh, E S, Bidye, Durgesh Paresh, Pujar, Gurubasavaraj, Dixit, Sheshagiri

“…•Modification of the sugar nucleoside analogue.•Substitution of furanose ring with various substituted uracil and synthesis of L-Nucleosides.•The synthesized…”
Get full text

Advances in HER2-Targeted Therapies: From monoclonal antibodies to dual inhibitors developments in cancer treatment by Bhagyalalitha, Meduri, Handattu Shankaranarayana, Akshatha, Arun Kumar, Sethu, Singh, Manisha, Pujar, Karthik G, Bidye, Durgesh, Veeranna Pujar, Gurubasavaraj

“…[Display omitted] •HER2-targeted therapies, like trastuzumab, are effective in treating HER2-driven cancers when combined with other therapeutic…”
Get full text

Quinoline Based thiazolidinediones: Design, Synthesis, In Silico, In Vitro, Antioxidant and Antidiabetic Evaluation by Mohd, Sharfuddin, Bidye, Durgesh Paresh, Dixit, Sheshagiri R, Revanasiddappa, B. C., Harish, Vancha, Kumar, Rakesh, Sharma, Vikas

“…In the present research work a sequence of substituted quinoline based thiazolidinedione moieties (12a–h) were designed and synthesized as potential…”
Get full text

Novel Antitubercular Agents: Design, Synthesis, Molecular Dynamic and Biological Studies of Pyrazole – 1,2,4‐Triazole Conjugates by Ajin, K. A., Arun Kumar, Sethu, Singh, Manisha, Akshatha, H. S., Bhagyalalitha, Meduri, Pujar, Karthik G., Sumana, M. N., Chandrashekar, V. M., Bidye, Durgesh, Pujar, Gurubasavaraj Veeranna

“…Mycobacterium tuberculosis (Mtb) has numerous cell wall and non‐cell wall mediated receptors for drug action, of which cell wall mediated targets were found to…”
Get full text