Search Results - "Biddlecombe, R. A."

Automated protein precipitation by filtration in the 96-well format by Biddlecombe, Robert A, Pleasance, Stephen

“…The use of automated protein precipitation by filtration in the 96-well format as a rapid sample preparation technique for high throughput bioanalysis using…”
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Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review by Plumb, R. S., Dear, G. J., Mallett, D. N., Higton, D. M., Pleasance, S., Biddlecombe, R. A.

“…1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and…”
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Circadian variation of GH-independent IGF-binding protein in diabetes mellitus and its relationship to insulin. A new role for insulin? by Holly, J M, Biddlecombe, R A, Dunger, D B, Edge, J A, Amiel, S A, Howell, R, Chard, T, Rees, L H, Wass, J A

“…Evidence is accumulating that a non-GH dependent insulin-like growth factor-binding protein (IGF-BP) is not only a carrier protein but also has an active role…”
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Levels of the small insulin-like growth factor-binding protein are strongly related to those of insulin in prepubertal and pubertal children but only weakly so after puberty by Holly, J M, Smith, C P, Dunger, D B, Edge, J A, Biddlecombe, R A, Williams, A J, Howell, R, Chard, T, Savage, M O, Rees, L H

“…We have looked at the relationship between fasting levels of insulin and a small insulin-like growth factor (IGF)-binding protein (IBP-1) in a cross-sectional…”
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Validation of a radioimmunoassay for the determination of human plasma concentrations of lamotrigine by Biddlecombe, R A, Dean, K L, Smith, C D, Jeal, S C

“…A precise and sensitive radioimmunoassay to determine human plasma lamotrigine (430C78), Lamictal) is described. The method is a direct double antibody…”
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A clinical trial on a plate? The potential of 384-well format solid phase extraction for high-throughput bioanalysis using liquid chromatography/tandem mass spectrometry by Biddlecombe, Robert A., Benevides, Christopher, Pleasance, Stephen

“…The application of 384‐well format solid phase extraction (SPE) for bioanalysis using liquid chromatography/tandem mass spectrometry (LC/MS/MS) is reported and…”
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Determination of the glucocorticoid fluticasone propionate in plasma by automated solid-phase extraction and liquid chromatography–tandem mass spectrometry by Callejas, Sheryl L, Biddlecombe, Robert A, Jones, Anne E, Joyce, Karina B, Pereira, Adrian I, Pleasance, Stephen

“…A sensitive, robust and high throughput mass spectrometry based method is described for the determination of the glucocorticoid fluticasone propionate in…”
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Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry : a review: The Drug Metabolism Discussion Group in 2001 by PLUMB, R. S, DEAR, G. J, MALLETT, D. N, HIGTON, D. M, PLEASANCE, S, BIDDLECOMBE, R. A

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Determination of the enantiomers of salbutamol and its 4-O-sulphate metabolites in biological matrices by chiral liquid chromatography tandem mass spectrometry by Joyce, Karina B., Jones, Anne E., Scott, Rebecca J., Biddlecombe, Robert A., Pleasance, Stephen

“…Sensitive, mass spectrometry based bioanalytical methods are described for the determination of the R‐ and S‐enantiomers of the β‐agonist salbutamol…”
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170 NON-GH DEPENDENT INSUL IN-LIKE GROWTH FACTOR BINDING PROTEIN (IGF-BP) PROF ILES IN DIABETIC ADOLESCENTS by Biddlecombe, R A, Holly, J M P, Dunger, D B, Edge, J A, Amiel, S A, Howell, R, Chard, I, Rees, L H, Wass, J A H, Savage, M O

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