Search Results - "Biddlecombe, James G."

Factors influencing antibody stability at solid-liquid interfaces in a high shear environment by Biddlecombe, James G., Smith, Graeme, Uddin, Shahid, Mulot, Sandrine, Spencer, David, Gee, Chris, Fish, Brendan C., Bracewell, Daniel G.

“…A rotating disk shear device was used to study the effect of interfacial shear on the structural integrity of human monoclonal antibodies of IgG4 isotype…”
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Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations by Beech, Karen E., Biddlecombe, James G., van der Walle, Christopher F., Stevens, Lee A., Rigby, Sean P., Burley, Jonathan C., Allen, Stephanie

“…[Display omitted] Lyophilized protein formulations must be reconstituted back into solution prior to patient administration and in this regard long…”
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Computational fluid dynamics (CFD) insights into agitation stress methods in biopharmaceutical development by Bai, Ge, Bee, Jared S., Biddlecombe, James G., Chen, Quanmin, Leach, W. Thomas

“…Agitation of small amounts of liquid is performed routinely in biopharmaceutical process, formulation, and packaging development. Protein degradation commonly…”
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Determining Antibody Stability: Creation of Solid-Liquid Interfacial Effects within a High Shear Environment by Biddlecombe, James G., Craig, Alan V., Zhang, Hu, Uddin, Shahid, Mulot, Sandrine, Fish, Brendan C., Bracewell, Daniel G.

“…The purpose of this study was to assess the stability of protein formulations using a device designed to generate defined, quantifiable levels of shear in the…”
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