Search Results - "Biddison, WE"

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways by Germain, Ronald N, Štefanová, Irena, Hemmer, Bernhard, Vergelli, Marco, Martin, Roland, Biddison, William E

“…Functional discrimination between structurally similar self and foreign antigens is a main attribute of adaptive immunity. Here we describe two feedback…”
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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 by Garboczi, David N, Ghosh, Partho, Utz, Ursula, Fan, Qing R, Biddison, William E, Wiley, Don C

“…Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the…”
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Four A6-TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical by Ding, Yuan-Hua, Baker, Brian M, Garboczi, David N, Biddison, William E, Wiley, Don C

“…The interactions of three singly substituted peptide variants of the HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been studied using T…”
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Clustering of Non-Major Histocompatibility Complex Susceptibility Candidate Loci in Human Autoimmune Diseases by Becker, Kevin G., Simon, Richard M., Bailey-Wilson, Joan E., Freidlin, Boris, Biddison, William E., McFarland, Henry F., Trent, Jeffrey M.

“…Human autoimmune diseases are thought to develop through a complex combination of genetic and environmental factors. Genome-wide linkage searches of autoimmune…”
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Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids by Ding, Yuan-Hua, Smith, Kathrine J., Garboczi, David N., Utz, Ursula, Biddison, William E., Wiley, Don C.

“…The three-dimensional structure of a human αβ T cell receptor (TCR), B7, bound to the HLA-A2 molecule/HTLV-1 Tax peptide complex was determined by x-ray…”
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A Correlation between TCR Vα Docking on MHC and CD8 Dependence: Implications for T Cell Selection by Buslepp, Jennifer, Wang, Huanchen, Biddison, William E, Appella, Ettore, Collins, Edward J

“…T cell receptors (TCR) adopt a similar orientation when binding with major histocompatibility complex (MHC) molecules, yet the biological mechanism that…”
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Conversion of a T Cell Antagonist into an Agonist by Repairing a Defect in the TCR/Peptide/MHC Interface: Implications for TCR Signaling by Baker, Brian M., Gagnon, Susan J., Biddison, William E., Wiley, Don C.

“…The structure of the A6 αβTCR/HTLV-1 Tax-peptide/MHC I complex with proline 6 of Tax substituted with alanine (P6A), an antagonist, is nearly identical to the…”
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The Structure and Stability of an HLA-A0201/Octameric Tax Peptide Complex with an Empty Conserved Peptide-N-Terminal Binding Site by Khan, Amir R, Baker, Brian M, Ghosh, Partho, Biddison, William E, Wiley, Don C

“…The crystal structure of the human class I MHC molecule HLA-A2 complexed with of an octameric peptide, Tax8 (LFGYPVYV), from human T cell lymphotrophic virus-1…”
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Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions by Whitney, Laurie Ward, Ludwin, Samuel K, McFarland, Henry F, Biddison, William E

“…Multiple sclerosis (MS) is a demyelinating disease of the central nervous system characterized by lesions that are areas of blood–brain barrier breakdown,…”
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CD8+ T Cell-Mediated HLA-A0201-Restricted Cytotoxicity to Transaldolase Peptide 168-176 in Patients with Multiple Sclerosis by Niland, Brian, Banki, Katalin, Biddison, William E, Perl, Andras

“…Transaldolase (TAL) is expressed at selectively high levels in oligodendrocytes and targeted by autoreactive T cells of patients with multiple sclerosis (MS)…”
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Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays by Ward Whitney, Laurie, Becker, Kevin G., Tresser, Nancy J., Caballero-Ramos, Carla I., Munson, Peter J., Prabhu, Vinayakumar V., Trent, Jeffrey M., McFarland, Henry F., Biddison, William E.

“…In multiple sclerosis (MS) patients, a coordinated attack of the immune system against the primary constituents of oligodendrocytes and/or the myelin sheath of…”
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MHC Class I-Restricted Lysis of Human Oligodendrocytes by Myelin Basic Protein Peptide-Specific CD8 T Lymphocytes by Jurewicz, Anna, Biddison, William E, Antel, Jack P

“…Multiple sclerosis (MS) is considered to be an autoimmune disease that is directed either at myelin or at its cell of origin, the oligodendrocytes (OL). The…”
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Combinatorial Peptide Libraries and Biometric Score Matrices Permit the Quantitative Analysis of Specific and Degenerate Interactions Between Clonotypic TCR and MHC Peptide Ligands by Zhao, Yingdong, Gran23, Bruno, Pinilla, Clemencia, Markovic-Plese, Silva, Hemmer, Bernhard, Tzou, Abraham, Whitney, Laurie Ward, Biddison, William E, Martin, Roland, Simon, Richard

“…The interaction of TCRs with MHC peptide ligands can be highly flexible, so that many different peptides are recognized by the same TCR in the context of a…”
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Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones by Malnati, Mauro S., Peruzzi, Marta, Parker, Kenneth C., Biddison, William E., Ciccone, Ermanno, Moretta, Alessandro, Long, Eric O.

“…Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here,…”
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Evidence for Rapid Disappearance of Initially Expanded HIV-Specific CD8+T Cell Clones during Primary HIV Infection by Pantaleo, Giuseppe, Soudeyns, Hugo, Demarest, James F., Vaccarezza, Mauro, Graziosi, Cecilia, Paolucci, Stefania, Daucher, MaryBeth, Cohen, Oren J., Denis, Francois, Biddison, William E., Sekaly, Rafick P., Fauci, Anthony S.

“…Down-regulation of the initial burst of viremia during primary HIV infection is thought to be mediated predominantly by HIV-specific cytotoxic T lymphocytes,…”
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Unraveling a Hotspot for TCR Recognition on HLA-A2: Evidence Against the Existence of Peptide-independent TCR Binding Determinants by Gagnon, Susan J., Borbulevych, Oleg Y., Davis-Harrison, Rebecca L., Baxter, Tiffany K., Clemens, John R., Armstrong, Kathryn M., Turner, Richard V., Damirjian, Marale, Biddison, William E., Baker, Brian M.

“…T cell receptor (TCR) recognition of peptide takes place in the context of the major histocompatibility complex (MHC) molecule, which accounts for…”
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Assembly, specific binding, and crystallization of a human TCR- alpha beta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2 by Garboczi, D N, Utz, U, Ghosh, P, Seth, A, Kim, Jongsun, VanTienhoven, EAE, Biddison, W E, Wiley, D C

“…T lymphocytes use TCR- alpha beta to bind and to recognize complexes of antigenic peptides bound to MHC proteins located at the surface of APCs. We have…”
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Shapes of MHC Restriction by Garboczi, David N, Biddison, William E

“…The defining component of antigen-specific recognition by T lymphocytes with alpha beta T cell receptors (TCRs) is MHC restriction. The concept of MHC…”
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Thermodynamic and Kinetic Analysis of a Peptide−Class I MHC Interaction Highlights the Noncovalent Nature and Conformational Dynamics of the Class I Heterotrimer by Binz, Anne-Kathrin, Rodriguez, Rene C, Biddison, William E, Baker, Brian M

“…The class I major histocompatibility (MHC) molecule is a heterotrimer composed of a heavy chain, the small subunit β2-microglobulin (β2m), and a peptide…”
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CARE-LASS (calcein-release-assay), an improved fluorescence-based test system to measure cytotoxic T lymphocyte activity by Lichtenfels, R, Biddison, W E, Schulz, H, Vogt, A B, Martin, R

“…CARE-LASS is a highly sensitive, fast, simple and safe fluorometric microassay. Target cells are loaded with acetoxymethyl ester of calcein (calcein-AM) that…”
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