Search Results - "Bicks, Lucy"

Social functioning in major depressive disorder by Kupferberg, Aleksandra, Bicks, Lucy, Hasler, Gregor

“…Depression is associated with social risk factors, social impairments and poor social functioning. This paper gives an overview of these social aspects using…”
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Prefrontal Cortex and Social Cognition in Mouse and Man by Bicks, Lucy K, Koike, Hiroyuki, Akbarian, Schahram, Morishita, Hirofumi

“…Social cognition is a complex process that requires the integration of a wide variety of behaviors, including salience, reward-seeking, motivation, knowledge…”
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Functional neurogenomics in autism spectrum disorders: A decade of progress by Bicks, Lucy K., Geschwind, D.H.

“…Advances in autism spectrum disorder (ASD) genetics have identified many genetic causes, reflecting remarkable progress while at the same time identifying…”
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A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice by Yamamuro, Kazuhiko, Bicks, Lucy K., Leventhal, Michael B., Kato, Daisuke, Im, Susanna, Flanigan, Meghan E., Garkun, Yury, Norman, Kevin J., Caro, Keaven, Sadahiro, Masato, Kullander, Klas, Akbarian, Schahram, Russo, Scott J., Morishita, Hirofumi

“…Juvenile social isolation reduces sociability in adulthood, but the underlying neural circuit mechanisms are poorly understood. We found that, in male mice, 2…”
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Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior by Bicks, Lucy K., Yamamuro, Kazuhiko, Flanigan, Meghan E., Kim, Julia Minjung, Kato, Daisuke, Lucas, Elizabeth K., Koike, Hiroyuki, Peng, Michelle S., Brady, Daniel M., Chandrasekaran, Sandhya, Norman, Kevin J., Smith, Milo R., Clem, Roger L., Russo, Scott J., Akbarian, Schahram, Morishita, Hirofumi

“…Social isolation during the juvenile critical window is detrimental to proper functioning of the prefrontal cortex (PFC) and establishment of appropriate adult…”
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The contributions of rare inherited and polygenic risk to ASD in multiplex families by Cirnigliaro, Matilde, Chang, Timothy S, Arteaga, Stephanie A, Pérez-Cano, Laura, Ruzzo, Elizabeth K, Gordon, Aaron, Bicks, Lucy K, Jung, Jae-Yoon, Lowe, Jennifer K, Wall, Dennis P, Geschwind, Daniel H

“…Autism spectrum disorder (ASD) has a complex genetic architecture involving contributions from both de novo and inherited variation. Few studies have been…”
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Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility by Heshmati, Mitra, Aleyasin, Hossein, Menard, Caroline, Christoffel, Daniel J., Flanigan, Meghan E., Pfau, Madeline L., Hodes, Georgia E., Lepack, Ashley E., Bicks, Lucy K., Takahashi, Aki, Chandra, Ramesh, Turecki, Gustavo, Lobo, Mary Kay, Maze, Ian, Golden, Sam A., Russo, Scott J.

“…Behavioral coping strategies are critical for active resilience to stress and depression; here we describe a role for neuroligin-2 (NLGN-2) in the nucleus…”
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The epigenomics of schizophrenia, in the mouse by Javidfar, Behnam, Park, Royce, Kassim, Bibi S., Bicks, Lucy K., Akbarian, Schahram

“…Large‐scale consortia including the Psychiatric Genomics Consortium, the Common Minds Consortium, BrainSeq and PsychENCODE, and many other studies taken…”
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Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia by Morishita, Hirofumi, Kundakovic, Marija, Bicks, Lucy, Mitchell, Amanda, Akbarian, Schahram

“…•GABAergic and Parvalbuminergic interneurons (PVIs) are disrupted in schizophrenia.•PVIs mediate juvenile plasticity and provide long-lasting impact on adult…”
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An Adolescent Sensitive Period for Social Dominance Hierarchy Plasticity Is Regulated by Cortical Plasticity Modulators in Mice by Bicks, Lucy K, Peng, Michelle, Taub, Alana, Akbarian, Schahram, Morishita, Hirofumi

“…Social dominance hierarchies are a common adaptation to group living and exist across a broad range of the animal kingdom. Social dominance is known to rely on…”
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Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions by Chandrasekaran, Sandhya, Espeso-Gil, Sergio, Loh, Yong-Hwee Eddie, Javidfar, Behnam, Kassim, Bibi, Zhu, Yueyan, Zhang, Yuan, Dong, Yuhao, Bicks, Lucy K., Li, Haixin, Rajarajan, Prashanth, Peter, Cyril J., Sun, Daijing, Agullo-Pascual, Esperanza, Iskhakova, Marina, Estill, Molly, Lesch, Bluma J., Shen, Li, Jiang, Yan, Akbarian, Schahram

“…Regulatory mechanisms associated with repeat-rich sequences and chromosomal conformations in mature neurons remain unexplored. Here, we map cell-type specific…”
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Neuronal protein interaction networks in autism spectrum disorder by Bicks, Lucy K., Eyring, Katherine Wade, Geschwind, Daniel H.

“…How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al.1…”
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Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex by Mitchell, Amanda C., Javidfar, Behnam, Bicks, Lucy K., Neve, Rachael, Garbett, Krassimira, Lander, Sharon S., Mirnics, Karoly, Morishita, Hirofumi, Wood, Marcelo A., Jiang, Yan, Gaisler-Salomon, Inna, Akbarian, Schahram

“…Neuronal epigenomes, including chromosomal loopings moving distal cis -regulatory elements into proximity of target genes, could serve as molecular proxy…”
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FUNCTIONAL GENOMIC ANNOTATION AND BIOLOGICAL INTERPRETATION OF ASD COMMON GENETIC RISK by Bicks, Lucy, Margolis, Michael, Guo, Qiuyu, Geschwind, Daniel

“…The Geschwind lab has used gene network analysis to robustly characterize the co-expression structure of the human brain, both in adult and fetal tissues. In…”
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Molecular cascades and cell type-specific signatures in ASD revealed by single-cell genomics by Wamsley, Brie, Bicks, Lucy, Cheng, Yuyan, Kawaguchi, Riki, Quintero, Diana, Margolis, Michael, Grundman, Jennifer, Liu, Jianyin, Xiao, Shaohua, Hawken, Natalie, Mazariegos, Samantha, Geschwind, Daniel H

“…Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes. What drives these changes and how they…”
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S189. PREFRONTAL PARVALBUMIN INTERNEURONS REQUIRE JUVENILE SOCIAL EXPERIENCE TO ESTABLISH ADULT SOCIAL BEHAVIOR by Bicks, Lucy, Yamamuro, Kazuhiko, Flanigan, Meghan, Lucas, Elizabeth, Koike, Hiroyuki, Kato, Daisuke, Russo, Scott, Akbarian, Schahram, Morishita, Hirofumi

“…Abstract Background Social isolation during developmental critical windows could be highly detrimental to proper functioning of mature prefrontal cortex (PFC)…”
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MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice by Mitchell, A C, Javidfar, B, Pothula, V, Ibi, D, Shen, E Y, Peter, C J, Bicks, L K, Fehr, T, Jiang, Y, Brennand, K J, Neve, R L, Gonzalez-Maeso, J, Akbarian, S

“…Large-scale consortia mapping the genomic risk architectures of schizophrenia provide vast amounts of molecular information, with largely unexplored…”
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Massively parallel characterization of regulatory elements in the developing human cortex by Deng, Chengyu, Whalen, Sean, Steyert, Marilyn, Ziffra, Ryan, Przytycki, Pawel F, Inoue, Fumitaka, Pereira, Daniela A, Capauto, Davide, Norton, Scott, Vaccarino, Flora M, Pollen, Alex A, Nowakowski, Tomasz J, Ahituv, Nadav, Pollard, Katherine S

“…Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in…”
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A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex by Huuki-Myers, Louise A, Spangler, Abby, Eagles, Nicholas J, Montgomery, Kelsey D, Kwon, Sang Ho, Guo, Boyi, Grant-Peters, Melissa, Divecha, Heena R, Tippani, Madhavi, Sriworarat, Chaichontat, Nguyen, Annie B, Ravichandran, Prashanthi, Tran, Matthew N, Seyedian, Arta, Hyde, Thomas M, Kleinman, Joel E, Battle, Alexis, Page, Stephanie C, Ryten, Mina, Hicks, Stephanie C, Martinowich, Keri, Collado-Torres, Leonardo, Maynard, Kristen R

“…The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, emerging spatial…”
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Single-cell multi-cohort dissection of the schizophrenia transcriptome by Ruzicka, W Brad, Mohammadi, Shahin, Fullard, John F, Davila-Velderrain, Jose, Subburaju, Sivan, Tso, Daniel Reed, Hourihan, Makayla, Jiang, Shan, Lee, Hao-Chih, Bendl, Jaroslav, Voloudakis, Georgios, Haroutunian, Vahram, Hoffman, Gabriel E, Roussos, Panos, Kellis, Manolis

“…The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation and the development of more effective therapies. Here, we performed…”
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